GENE：VCAN
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | VCAN |
| FullNmae | versican |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2464 |
| EnsembleID | ENSG00000038427 |
| Uniprot | P13611 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| VCAN | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| VCAN | GO:0001501,GO:0001649,GO:0001750,GO:0002052,GO:0005509,GO:0005515,GO:0005539,GO:0005540,GO:0005576,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005788,GO:0005796,GO:0007155,GO:0007417,GO:0008037,GO:0010001,GO:0016020,GO:0030021,GO:0030021,GO:0030246,GO:0031012,GO:0033165,GO:0043202,GO:0045202,GO:0062023,GO:0062023,GO:0072534 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| VCAN | hsa:1462 | path:hsa04514 | Cell adhesion molecules - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CXCL10 | VCAN | 11083865 23180781 | physical association | solid phase assay | InnateDB |
| VCAN | CCL2 | 11083865 23180781 | physical association | solid phase assay | InnateDB |
| VCAN | CCL8 | 11083865 23180781 | physical association | solid phase assay | InnateDB |
| VCAN | CCL20 | 11083865 23180781 | physical association | solid phase assay | InnateDB |
| PF4 | VCAN | 11083865 23180781 | physical association | solid phase assay | InnateDB |
| VCAN | CXCL12 | 11083865 23180781 | physical association | solid phase assay | InnateDB |
| VCAN | SELPLG | 15522894 23180781 | physical association | two hybrid | InnateDB |
| VCAN | SELL | 10221651 10950950 23180781 | physical association | anti tag coimmunoprecipitation,solid phase assay | InnateDB |
| VCAN | SELP | 10950950 23180781 | physical association | solid phase assay | InnateDB |
| VCAN | CD44 | 10950950 23180781 | physical association | solid phase assay | InnateDB |
| PITX3 | VCAN | 22278372 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CCL5 | VCAN | 11083865 23180781 | physical association | solid phase assay | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | VCAN | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | VCAN | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | VCAN | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA1 | VCAN | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | VCAN | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | VCAN | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | VCAN | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | VCAN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | VCAN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | VCAN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | VCAN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | VCAN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | VCAN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | VCAN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | VCAN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | VCAN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | VCAN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | VCAN | 12438652 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | VCAN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TCF7L2 | VCAN | 19269971 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TCF4 | VCAN | 19269971 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00002E1509 | VCAN | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000008F0CF | VCAN | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001941B8 | VCAN | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237AF9 | VCAN | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040FA88 | VCAN | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000183BED | VCAN | 25416803 28035060 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS000027080C | VCAN | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00000CF1D2 | VCAN | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FF522 | VCAN | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00005E6F45 | VCAN | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SRGN | VCAN | 23601700 24234451 25348397 | physical association | zymography,comigration in gel electrophoresis | ComPPI,IntAct |
| TAFA4 | VCAN | 25348397 | N/A | physical interaction | ComPPI |
| CD44 | VCAN | 10950950 14525934 25348397 | N/A | experimental interaction detection,physical interaction,solid phase assay | ComPPI,HPRD |
| PF4 | VCAN | 25348397 | N/A | physical interaction | ComPPI |
| SELP | VCAN | 10950950 14525934 25348397 | N/A | experimental interaction detection,physical interaction,solid phase assay | ComPPI,HPRD |
| CCL5 | VCAN | 11083865 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| BCAN | VCAN | 25348397 | N/A | physical interaction | ComPPI |
| CCL8 | VCAN | 11083865 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| CXCL12 | VCAN | 25348397 | N/A | physical interaction | ComPPI |
| SELL | VCAN | 10221651 10950950 12556525 25348397 27898060 | N/A | physical interaction,solid phase assay | ComPPI,OmniPath |
| FBN1 | VCAN | 11726670 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| CCL21 | VCAN | 11083865 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| CCL2 | VCAN | 11083865 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| CCL20 | VCAN | 11083865 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| HAPLN1 | VCAN | 12888576 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| MMP9 | VCAN | 23601700 24234451 25348397 | physical association | zymography,comigration in gel electrophoresis | ComPPI,IntAct |
| HSFX1 | VCAN | 24234451 25036637 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| VCAN | FBLN2 | 11038354 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| VCAN | FAM20C | 22582013 24234451 25348397 | phosphorylation reaction | protein kinase assay | ComPPI,IntAct |
| SELPLG | VCAN | 14525934 15522894 27898060 | N/A | experimental interaction detection,two hybrid | HPRD,OmniPath |
| VCAN | VCAN | 11083865 14525934 | N/A | experimental interaction detection | HPRD |
| FBLN1 | VCAN | 10400671 14525934 | N/A | experimental interaction detection | HPRD |
| CXCL10 | VCAN | 11083865 14525934 | N/A | experimental interaction detection | HPRD |
| PLA2G2A | VCAN | 14525934 27898060 8824283 9848887 | N/A | experimental interaction detection | HPRD,OmniPath |
| ITGA4 | VCAN | 11083865 14525934 | N/A | experimental interaction detection | HPRD |
| XCL1 | VCAN | 11083865 14525934 | N/A | experimental interaction detection | HPRD |
| TNR | VCAN | 14525934 9294172 | N/A | experimental interaction detection | HPRD |
| ADAMTS1 | VCAN | 11278559 12907688 14525934 | N/A | experimental interaction detection | HPRD |
| ITGB1 | VCAN | 11805102 27898060 | N/A | N/A | OmniPath |
| VCAN | EGFR | 16045811 27898060 | N/A | N/A | OmniPath |
| VCAN | TLR2 | 19122641 27898060 | N/A | N/A | OmniPath |
| TP53 | VCAN | 18431400 27898060 | stimulant | N/A | OmniPath |
| VCAN | CCL8 | 11083865 27898060 | N/A | N/A | OmniPath |
| CCL8 | VCAN | 11083865 27898060 | N/A | N/A | OmniPath |
| VCAN | CXCL12 | 11083865 27898060 | N/A | N/A | OmniPath |
| CXCL12 | VCAN | 11083865 27898060 | N/A | N/A | OmniPath |
| CCL2 | VCAN | 11083865 27898060 | N/A | N/A | OmniPath |
| VCAN | CCL2 | 11083865 27898060 | N/A | N/A | OmniPath |
| CXCL10 | VCAN | 11083865 27898060 | N/A | N/A | OmniPath |
| PF4 | VCAN | 11083865 27898060 | N/A | N/A | OmniPath |
| VCAN | PF4 | 11083865 27898060 | N/A | N/A | OmniPath |
| VCAN | CCL20 | 11083865 27898060 | N/A | N/A | OmniPath |
| CCL20 | VCAN | 11083865 27898060 | N/A | N/A | OmniPath |
| ADAMTS1 | VCAN | 11278559 12907688 27898060 | stimulant | N/A | OmniPath |