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GENE：TICAM1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TICAM1
FullNmae TIR domain containing adaptor molecule 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:18348
EnsembleID ENSG00000127666
Uniprot Q8IUC6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TICAM1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TICAM1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TICAM1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
TICAM1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TICAM1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TICAM1 GO:0002224,GO:0002281,GO:0002735,GO:0002735,GO:0005515,GO:0005739,GO:0005768,GO:0005769,GO:0005776,GO:0005829,GO:0006809,GO:0006954,GO:0007249,GO:0010008,GO:0010008,GO:0010508,GO:0010628,GO:0019901,GO:0019901,GO:0030890,GO:0031398,GO:0031663,GO:0032481,GO:0032722,GO:0032728,GO:0032755,GO:0032760,GO:0032816,GO:0034138,GO:0035666,GO:0035666,GO:0035666,GO:0042100,GO:0043123,GO:0043123,GO:0043123,GO:0043123,GO:0043254,GO:0043330,GO:0043330,GO:0043330,GO:0045087,GO:0045429,GO:0051092,GO:0051607,GO:0060090,GO:0060907,GO:0071222,GO:0097190,GO:0097342,GO:0140052,GO:1900017,GO:1900017

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TICAM1 hsa:148022 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
TICAM1 hsa:148022 path:hsa04217 Necroptosis - Homo sapiens (human)
TICAM1 hsa:148022 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
TICAM1 hsa:148022 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
TICAM1 hsa:148022 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
TICAM1 hsa:148022 path:hsa05133 Pertussis - Homo sapiens (human)
TICAM1 hsa:148022 path:hsa05135 Yersinia infection - Homo sapiens (human)
TICAM1 hsa:148022 path:hsa05142 Chagas disease - Homo sapiens (human)
TICAM1 hsa:148022 path:hsa05160 Hepatitis C - Homo sapiens (human)
TICAM1 hsa:148022 path:hsa05161 Hepatitis B - Homo sapiens (human)
TICAM1 hsa:148022 path:hsa05164 Influenza A - Homo sapiens (human)
TICAM1 hsa:148022 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
TICAM1 hsa:148022 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
TICAM1 hsa:148022 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
TICAM1 hsa:148022 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
TICAM1 hsa:148022 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TLR4 TICAM1 11672593 11964313 12032143 12811837 15644117 16306937 16917499 17114424 20154735 20547845 23508573 26192618 association N/A ACSN
TICAM1 IFNG 11672593 11964313 12032143 12811837 15644117 16306937 16917499 17114424 20154735 20547845 23508573 26192618 interaction type N/A ACSN
TICAM1 TRAF3 11672593 11964313 12032143 12811837 15644117 16306936 16306937 16917499 17114424 17327220 18450748 20154735 20418377 20547845 23180781 23508573 26192618 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
TICAM1 TMED7 12721283 14519765 19412184 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TICAM1 TLR3 12471095 12539043 14519765 14982987 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TICAM1 IRF3 12471095 14739303 16281057 23180781 physical association anti tag coimmunoprecipitation InnateDB
TICAM1 TRAF4 16052631 23180781 physical association anti tag coimmunoprecipitation InnateDB
TICAM1 TNFAIP3 15474016 23180781 physical association anti tag coimmunoprecipitation InnateDB
TICAM1 RIPK2 15814722 23180781 physical association anti tag coimmunoprecipitation InnateDB
TICAM1 IKBKB 14739303 23180781 physical association anti tag coimmunoprecipitation InnateDB
TICAM1 TLR4 14519765 19656901 23180781 physical association anti tag coimmunoprecipitation InnateDB
TICAM1 TRAF6 14530355 14739303 14982987 16281057 19795416 20047764 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TICAM1 TRAF1 16323247 19795416 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TICAM1 TBK1 14530355 14739303 16281057 19416887 19656901 20200155 20418377 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
TICAM1 TLR2 12471095 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF7 TICAM1 14739303 23180781 physical association anti tag coimmunoprecipitation InnateDB
TICAM1 PIK3CA 15940673 23180781 physical association anti tag coimmunoprecipitation InnateDB
TICAM1 MAVS 16153868 23180781 physical association anti tag coimmunoprecipitation InnateDB
TICAM1 RIPK1 15814722 16281057 17982077 18450748 19734906 20200155 23180781 physical association anti tag coimmunoprecipitation,fluorescent resonance energy transfer InnateDB
TICAM1 SARM1 16964262 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TICAM1 TANK 17327220 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
TICAM1 AZI2 15611223 17982077 23180781 physical association anti tag coimmunoprecipitation,fluorescent resonance energy transfer InnateDB
TICAM1 TICAM1 14530355 18450748 20200155 20404851 20418377 23180781 24255114 26467481 bind,physical association,up-regulates activity anti tag coimmunoprecipitation,two hybrid InnateDB,Signor
PIAS4 TICAM1 15251447 23180781 physical association anti tag coimmunoprecipitation InnateDB
TICAM1 TRAF2 19795416 20047764 20418377 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TICAM1 ZMYND11 19795416 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TICAM1 TLR5 20855887 23180781 physical association anti tag coimmunoprecipitation InnateDB
TICAM1 UBQLN1 21695056 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP8 TICAM1 22421964 23180781 physical association anti tag coimmunoprecipitation InnateDB
TICAM1 TRIM56 22948160 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKBKE TICAM1 14739303 23180781 physical association anti tag coimmunoprecipitation InnateDB
TICAM1 IKBKE 16281057 23180781 physical association anti tag coimmunoprecipitation InnateDB
TICAM1 TICAM2 23180781 24255114 physical association anti tag coimmunoprecipitation,two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
TICAM1 TLR3 20005715 interaction type N/A PSP
TICAM1 TNFAIP3 20005715 interaction type N/A PSP
TICAM1 RIPK1 20005715 interaction type N/A PSP
TICAM1 TICAM2 20005715 interaction type N/A PSP
TICAM1 RIPK3 20005715 interaction type N/A PSP
TICAM1 RIPK1 15064760 19734906 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR TICAM1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 TICAM1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF TICAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TICAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TICAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TICAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TICAM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 TICAM1 14960149 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 TICAM1 14960149 trascriptional regulation,stimulation inferred by curator TFlink
TRAF6 TICAM1 14530355 20047764 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000170CF4 TICAM1 21236259 rna interference,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000170CF4 TICAM1 21236259 25416803 mrna cleavage,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000AA464 TICAM1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
TICAM1 RIPK1 25361965 interaction type N/A PTMCode2
RIPK1 TICAM1 25361965 interaction type N/A PTMCode2
TICAM1 IRF3 25361965 interaction type N/A PTMCode2
IRF3 TICAM1 25361965 interaction type N/A PTMCode2
TICAM1 TRAF6 25361965 interaction type N/A PTMCode2
TRAF6 TICAM1 25361965 interaction type N/A PTMCode2
TICAM1 IRF7 25361965 interaction type N/A PTMCode2
IRF7 TICAM1 25361965 interaction type N/A PTMCode2
TICAM1 TBK1 25361965 interaction type N/A PTMCode2
TBK1 TICAM1 25361965 interaction type N/A PTMCode2
TICAM1 TRAF3 25361965 interaction type N/A PTMCode2
TRAF3 TICAM1 25361965 interaction type N/A PTMCode2
TICAM1 IKBKE 25361965 interaction type N/A PTMCode2
IKBKE TICAM1 25361965 interaction type N/A PTMCode2
TICAM1 TIRAP 25361965 interaction type N/A PTMCode2
TIRAP TICAM1 25361965 interaction type N/A PTMCode2
RIPK3 TICAM1 25361965 interaction type N/A PTMCode2
TICAM1 RIPK3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TRIM38 TICAM1 25348397 N/A physical interaction ComPPI
TNFAIP3 TICAM1 14525934 15474016 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
TRAF6 TICAM1 14525934 14530355 14982987 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
SYK TICAM1 25348397 N/A physical interaction ComPPI
CBLB TICAM1 25348397 N/A physical interaction ComPPI
PIK3CA TICAM1 14525934 15940673 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
IRF3 TICAM1 14525934 14739303 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
CASP8 TICAM1 25348397 N/A physical interaction ComPPI
TIRAP TICAM1 25348397 N/A in vivo ComPPI
TRAF3 TICAM1 14525934 16306936 16306937 17991829 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MKNK2 TICAM1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XPO1 TICAM1 25348397 N/A physical interaction ComPPI
TRAF1 TICAM1 14525934 16323247 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
TRAF2 TICAM1 25348397 N/A physical interaction ComPPI
TRAF5 TICAM1 25348397 N/A physical interaction ComPPI
PIAS4 TICAM1 14525934 15251447 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
TLR2 TICAM1 12471095 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TLR4 TICAM1 25348397 N/A physical interaction ComPPI
RIPK1 TICAM1 14525934 15064760 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RIPK3 TICAM1 14525934 15064760 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TRAF4 TICAM1 14525934 16052631 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TICAM2 TICAM1 12721283 14519765 14525934 24234451 25348397 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
CFLAR TICAM1 25348397 N/A physical interaction ComPPI
CARM1 TICAM1 25348397 N/A physical interaction ComPPI
TRIM25 TICAM1 25348397 N/A physical interaction ComPPI
TBK1 TICAM1 14525934 14530355 15841462 19416887 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
UBQLN1 TICAM1 25348397 N/A physical interaction ComPPI
RNF216 TICAM1 25348397 N/A physical interaction ComPPI
TANK TICAM1 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TLR3 TICAM1 12539043 14525934 14982987 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
IRF7 TICAM1 14525934 14739303 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
TRAM1 TICAM1 12721283 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SRSF4 TICAM1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
IKBKE TICAM1 12692549 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TICAM1 AZI2 14525934 15611223 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TICAM1 MAVS 14525934 16153868 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TICAM1 TRIM56 25348397 N/A physical interaction ComPPI
TICAM1 KIF21B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TICAM1 CDCA5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TICAM1 FOSL1 25348397 N/A physical interaction ComPPI
TICAM1 CEP170P1 24234451 25348397 26496610 association anti tag coimmunoprecipitation ComPPI,IntAct
TICAM1 SARM1 24234451 25348397 26592460 N/A pull down ComPPI,IntAct
TICAM1 TNFAIP3 15474016 27898060 N/A N/A OmniPath
TRAF2 TICAM1 14982987 19795416 20047764 20418377 27898060 N/A N/A OmniPath
TICAM1 TRAF2 14982987 19795416 20047764 20418377 27898060 N/A N/A OmniPath
TICAM1 RIPK2 15814722 27898060 N/A N/A OmniPath
TICAM1 IKBKE 12692549 14739303 16281057 16410796 27898060 stimulant N/A OmniPath
TICAM2 TICAM1 12721283 14519765 16410796 24255114 25736436 27898060 stimulant N/A OmniPath
TICAM1 TRAF6 14530355 14739303 14751757 14982987 15474016 15932500 16281057 16410796 19795416 19898473 20047764 24812060 25736436 27898060 stimulant N/A OmniPath
TRAF6 TICAM1 14530355 14739303 14751757 14982987 15474016 15932500 16281057 19795416 19898473 20047764 24812060 25736436 27898060 N/A N/A OmniPath
TICAM1 MAVS 16153868 27898060 N/A N/A OmniPath
TLR4 TICAM1 14519765 18772134 19656901 19898473 25736436 27898060 stimulant N/A OmniPath
TICAM1 TLR4 14519765 18772134 19656901 19898473 25736436 27898060 N/A N/A OmniPath
TLR5 TICAM1 20855887 27898060 N/A N/A OmniPath
TICAM1 TLR2 12471095 27898060 N/A N/A OmniPath
TICAM1 PIK3CA 15940673 27898060 N/A N/A OmniPath
TICAM1 IRF3 12471095 14739303 16281057 27898060 stimulant N/A OmniPath
TICAM1 IRF7 14739303 27898060 N/A N/A OmniPath
TICAM1 TRAF4 16052631 27898060 N/A N/A OmniPath
TRAF4 TICAM1 16052631 27898060 N/A N/A OmniPath
TICAM1 RIPK1 14739303 15064760 15814722 16281057 16410796 17982077 18450748 19734906 20200155 20404851 25736436 27898060 stimulant N/A OmniPath
TLR3 TICAM1 12471095 12539043 14519765 14751757 14982987 15932500 16410796 25736436 27898060 stimulant N/A OmniPath
TICAM1 TLR3 12471095 12539043 14519765 14751757 14982987 15932500 25736436 27898060 N/A N/A OmniPath
TICAM1 TBK1 14530355 14739303 16281057 16410796 19416887 19656901 20200155 20418377 21903422 25736436 27898060 stimulant N/A OmniPath
TICAM1 TRAF3 14982987 16306936 16306937 17327220 17991829 18450748 20418377 24577058 27898060 stimulant N/A OmniPath
IKBKB TICAM1 14739303 27898060 N/A N/A OmniPath
TICAM1 PIAS4 15251447 27898060 N/A N/A OmniPath
TICAM1 TANK 17327220 21903422 27898060 N/A N/A OmniPath
TRIM56 TICAM1 22948160 27898060 N/A N/A OmniPath
TICAM1 TRAF1 14982987 16323247 19795416 27898060 stimulant N/A OmniPath
AZI2 TICAM1 15611223 17982077 27898060 N/A N/A OmniPath
TICAM1 UBQLN1 21695056 27898060 N/A N/A OmniPath
UBQLN1 TICAM1 21695056 27898060 N/A N/A OmniPath
TICAM1 TMED7 12721283 14519765 19412184 27898060 N/A N/A OmniPath
TMED7 TICAM1 12721283 14519765 19412184 27898060 N/A N/A OmniPath
SARM1 TICAM1 16964262 27898060 stimulant N/A OmniPath
TICAM1 ZMYND11 19795416 27898060 N/A N/A OmniPath

Visualization










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