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GENE：SORBS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SORBS1
FullNmae sorbin and SH3 domain containing 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14565
EnsembleID ENSG00000095637
Uniprot Q9BX66

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SORBS1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SORBS1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SORBS1 GO:0001725,GO:0003779,GO:0005158,GO:0005515,GO:0005634,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0005829,GO:0005886,GO:0005912,GO:0005915,GO:0005925,GO:0007160,GO:0008092,GO:0008286,GO:0016363,GO:0016600,GO:0030055,GO:0030055,GO:0030159,GO:0030159,GO:0031589,GO:0032869,GO:0043149,GO:0045121,GO:0045725,GO:0046326,GO:0046628,GO:0046889,GO:0048041,GO:1903078

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SORBS1 hsa:10580 path:hsa03320 PPAR signaling pathway - Homo sapiens (human)
SORBS1 hsa:10580 path:hsa04520 Adherens junction - Homo sapiens (human)
SORBS1 hsa:10580 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SORBS1 ABL1 20005715 interaction type N/A PSP
SORBS1 INSR 20005715 interaction type N/A PSP
SORBS1 PGR 20005715 interaction type N/A PSP
SORBS1 CBL 11001060 12504111 15128873 18988627 20005715 21071413 interaction type N/A PSP,SignaLink
SORBS1 PTK2 20005715 interaction type N/A PSP,SignaLink
SORBS1 PAK2 20005715 interaction type N/A PSP
SORBS1 PTK2B 20005715 interaction type N/A PSP,SignaLink
SORBS1 ABL1 11374898 18988627 20005715 N/A N/A SignaLink
SORBS1 INSR 11374898 11374898 18988627 20005715 20005715 21071413 N/A N/A SignaLink
SORBS1 PAK2 20005715 20005715 N/A N/A SignaLink
SORBS1 PGR 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR SORBS1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 SORBS1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SORBS1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 SORBS1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 SORBS1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SORBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SORBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SORBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SORBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SORBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SORBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SORBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SORBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SORBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SORBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SORBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 SORBS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003CF1AD SORBS1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
NCK2 SORBS1 25348397 N/A physical interaction ComPPI
PAK2 SORBS1 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,phage display,in vitro ComPPI,HPRD,IntAct
CDK6 SORBS1 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
ACTB SORBS1 19116150 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
CBL SORBS1 11001060 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
SRC SORBS1 25348397 N/A physical interaction ComPPI
SH2B2 SORBS1 11997497 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SOS1 SORBS1 25348397 N/A physical interaction ComPPI
KHDRBS1 SORBS1 25348397 N/A physical interaction ComPPI
SMAD2 SORBS1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
INPPL1 SORBS1 12504111 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
SORBS1 VCL 10085297 14525934 17082770 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SORBS1 EFNB1 11557983 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SORBS1 INSM1 12079283 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
SORBS1 FLOT1 11481476 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SORBS1 SEMA6A 12421765 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SORBS1 PGR 12650714 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
SORBS1 PXN 25348397 N/A in vitro,in vivo ComPPI
SORBS1 ADAM15 14525934 16374509 24234451 25348397 physical association experimental interaction detection,filter binding,in vitro ComPPI,HPRD,IntAct
SORBS1 ACTA1 14525934 17082770 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SORBS1 INSR 11374898 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SORBS1 EIF6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SORBS1 AFDN 25348397 N/A physical interaction ComPPI
SORBS1 ABL1 11374898 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
SORBS1 MAP4K3 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
SORBS1 CASP8 25348397 N/A physical interaction ComPPI
SORBS1 NTRK1 25348397 N/A physical interaction ComPPI
SORBS1 FRS2 25348397 N/A physical interaction ComPPI
SORBS1 TENM1 15777793 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SORBS1 SLC10A3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SORBS1 RPL4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SORBS1 PILRA 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SORBS1 LATS2 25348397 N/A physical interaction ComPPI
SORBS1 YWHAB 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SORBS1 CEP128 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SORBS1 CNTRL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SORBS1 FBF1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SORBS1 CDK4 25348397 N/A physical interaction ComPPI
SORBS1 TGS1 25348397 N/A physical interaction ComPPI
SORBS1 CDH1 25348397 N/A physical interaction ComPPI
SORBS1 G3BP1 25348397 N/A physical interaction ComPPI
SORBS1 DNM2 19116150 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation ComPPI,IntAct,OmniPath
SORBS1 MYC 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
SORBS1 ABI1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
SORBS1 ATXN7 23892081 24234451 25348397 27898060 colocalization isothermal titration calorimetry,nuclear magnetic resonance,pull down,fluorescence microscopy ComPPI,IntAct,OmniPath
SORBS1 HTT 17500595 24234451 25348397 physical association two hybrid ComPPI,IntAct
SORBS1 EZR 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SORBS1 CBL 11001060 11997497 12504111 12765336 15128873 17548467 27898060 9447983 stimulant N/A OmniPath
PPARG SORBS1 10734046 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009AD112 SORBS1 27087310 direct interaction,inhibition N/A NPInter

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