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GENE：SPTLC2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SPTLC2
FullNmae serine palmitoyltransferase long chain base subunit 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11278
EnsembleID ENSG00000100596
Uniprot O15270

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SPTLC2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SPTLC2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SPTLC2 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SPTLC2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SPTLC2 GO:0004758,GO:0004758,GO:0005789,GO:0005789,GO:0006686,GO:0017059,GO:0017059,GO:0017059,GO:0030148,GO:0030148,GO:0030170,GO:0046511,GO:0046512,GO:0046512,GO:0046513,GO:0046513,GO:0060612,GO:1904504

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SPTLC2 hsa:9517 path:hsa00600 Sphingolipid metabolism - Homo sapiens (human)
SPTLC2 hsa:9517 path:hsa01100 Metabolic pathways - Homo sapiens (human)
SPTLC2 hsa:9517 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR SPTLC2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SPTLC2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 SPTLC2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SPTLC2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SPTLC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SPTLC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SPTLC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SPTLC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SPTLC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 SPTLC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SPTLC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SPTLC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000486E0B SPTLC2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D SPTLC2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 SPTLC2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005E1A16 SPTLC2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 SPTLC2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000020579D SPTLC2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000913AC SPTLC2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000007FBA SPTLC2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000055128B SPTLC2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000077DDE SPTLC2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000007A060 SPTLC2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA SPTLC2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002E628F SPTLC2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 SPTLC2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 SPTLC2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 SPTLC2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F SPTLC2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA SPTLC2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 SPTLC2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 SPTLC2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C SPTLC2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 SPTLC2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 SPTLC2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 SPTLC2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE SPTLC2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A SPTLC2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075D860 SPTLC2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002F5FEE SPTLC2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001B12A4 SPTLC2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075E2C3 SPTLC2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000E7139 SPTLC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 SPTLC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002CEB74 SPTLC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 SPTLC2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000F31F4 SPTLC2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 SPTLC2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000345DEB SPTLC2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000451A1 SPTLC2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00003E226A SPTLC2 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000075C1E1 SPTLC2 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
NTRK1 SPTLC2 25348397 N/A physical interaction ComPPI
CFTR SPTLC2 25348397 N/A physical interaction ComPPI
PTPRN SPTLC2 25348397 N/A physical interaction ComPPI
NOTCH3 SPTLC2 25348397 N/A physical interaction ComPPI
TRIM25 SPTLC2 25348397 N/A physical interaction ComPPI
P2RX4 SPTLC2 25348397 N/A physical interaction ComPPI
WBP1 SPTLC2 25348397 N/A physical interaction ComPPI
SPTLC2 SPTLC1 10713067 10722674 11781309 14525934 19416851 20182505 24234451 25348397 27898060 physical association experimental interaction detection,ubiquitin reconstruction,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
SPTLC2 BCL6 16147992 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SPTLC2 NRG1 25348397 N/A physical interaction ComPPI
SPTLC2 COX6B1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct

Visualization










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