GENE：PTHLH
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PTHLH |
| FullNmae | parathyroid hormone like hormone |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9607 |
| EnsembleID | ENSG00000087494 |
| Uniprot | P12272 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PTHLH | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PTHLH | GO:0001501,GO:0002076,GO:0005179,GO:0005515,GO:0005576,GO:0005615,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0007189,GO:0007189,GO:0007267,GO:0007565,GO:0008284,GO:0008285,GO:0008544,GO:0010468,GO:0030282,GO:0032330,GO:0032331,GO:0046058,GO:0051428,GO:0051428,GO:0061182 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PTHLH | hsa:5744 | path:hsa04928 | Parathyroid hormone synthesis, secretion and action - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PTHLH | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| GATA2 | PTHLH | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SP1 | PTHLH | 8063775 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay,DNase I footprinting | TFlink |
| PRDM14 | PTHLH | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CTCF | PTHLH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | PTHLH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PTHLH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PTHLH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PTHLH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PTHLH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | PTHLH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | PTHLH | 11590145 15072578 8063775 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | PTHLH | 17554373 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | PTHLH | 17554373 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD3 | PTHLH | 24330518 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | PTHLH | 8063775 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS2 | PTHLH | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PPARG | PTHLH | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RARA | PTHLH | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RARB | PTHLH | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RARG | PTHLH | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD4 | PTHLH | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | PTHLH | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CDK2 | PTHLH | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| PTHLH | CDK2 | 25361965 | interaction type | N/A | PTMCode2 |
| PTH1R | PTHLH | 25361965 | interaction type | N/A | PTMCode2 |
| PTHLH | PTH1R | 25361965 | interaction type | N/A | PTMCode2 |
| KPNB1 | PTHLH | 25361965 | interaction type | N/A | PTMCode2 |
| PTHLH | KPNB1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KLK3 | PTHLH | 14525934 25348397 8683730 8753751 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PTH1R | PTHLH | 14525934 25348397 9108031 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| PTHLH | KPNB1 | 11401507 12504010 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,OmniPath |
| PTHLH | ARRB1 | 12220636 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| PTHLH | CDK2 | 10373465 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| PTHLH | IL6 | 12000745 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PTHLH | PLK1 | 19596235 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PTHLH | ELAVL1 | 25348397 | N/A | physical interaction | ComPPI |
| CDK2 | PTHLH | 10373465 12504010 27898060 | inhibition | N/A | OmniPath |
| CDK1 | PTHLH | 10373465 27898060 | inhibition | N/A | OmniPath |
| PTHLH | PTH1R | 2558877 27898060 8702701 9108031 | stimulant | N/A | OmniPath |
| PTHLH | PTH2R | 27898060 8702701 | N/A | N/A | OmniPath |