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GENE：DGKZ

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DGKZ
FullNmae diacylglycerol kinase zeta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2857
EnsembleID ENSG00000149091
Uniprot Q13574

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DGKZ parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DGKZ mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DGKZ GO:0004143,GO:0004143,GO:0004143,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006654,GO:0006654,GO:0006654,GO:0007205,GO:0016301,GO:0016477,GO:0016607,GO:0030027,GO:0030168,GO:0035556,GO:0046339,GO:0046339,GO:0046486,GO:0046834,GO:0046834,GO:0046872,GO:0050860,GO:0051966,GO:0090216

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DGKZ hsa:8525 path:hsa00561 Glycerolipid metabolism - Homo sapiens (human)
DGKZ hsa:8525 path:hsa00564 Glycerophospholipid metabolism - Homo sapiens (human)
DGKZ hsa:8525 path:hsa01100 Metabolic pathways - Homo sapiens (human)
DGKZ hsa:8525 path:hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
DGKZ hsa:8525 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
DGKZ hsa:8525 path:hsa05231 Choline metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HRAS DGKZ 11257115 23180781 physical association anti tag coimmunoprecipitation InnateDB
RASGRP1 DGKZ 11257115 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 DGKZ 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 DGKZ 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C DGKZ 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 DGKZ 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 DGKZ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DGKZ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DGKZ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DGKZ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DGKZ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 DGKZ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DGKZ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DGKZ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR DGKZ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 DGKZ 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 DGKZ 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00001597DC DGKZ 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EED18 DGKZ 25416803 28008152 mrna cleavage,inhibition experimental interaction detection TarBase

Source Target Pmid Interactiontype Methods Database
RASGRP1 DGKZ 25361965 interaction type N/A PTMCode2
DGKZ RASGRP1 25361965 interaction type N/A PTMCode2
DGKZ LEPR 25361965 interaction type N/A PTMCode2
LEPR DGKZ 25361965 interaction type N/A PTMCode2
DGKZ PLCB4 25361965 interaction type N/A PTMCode2
PLCB4 DGKZ 25361965 interaction type N/A PTMCode2
DGKZ DMD 25361965 interaction type N/A PTMCode2
DMD DGKZ 25361965 interaction type N/A PTMCode2
DGKZ SNX27 25361965 interaction type N/A PTMCode2
SNX27 DGKZ 25361965 interaction type N/A PTMCode2
PRKCA DGKZ 25361965 interaction type N/A PTMCode2
DGKZ PRKCA 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CBX8 DGKZ 21282530 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
SAT1 DGKZ 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
HRAS DGKZ 11257115 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKCA DGKZ 12890670 14525934 25348397 9716136 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SRC DGKZ 14525934 14707140 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RB1 DGKZ 14525934 16286473 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PIK3CA DGKZ 25348397 N/A physical interaction ComPPI
DGKZ SNTB1 11352924 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DGKZ SNTB2 11352924 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DGKZ LEPR 11078732 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
DGKZ SNTA1 11352924 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DGKZ RASGRP1 11257115 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
DGKZ SNTG1 11352924 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
DGKZ RBL1 14525934 16286473 25348397 N/A experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD
DGKZ RBL2 14525934 16286473 25348397 N/A experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD
DGKZ SNX27 14525934 17351151 25348397 27898060 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD,OmniPath
DGKZ PLCG1 12890670 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
DGKZ MYZAP 25348397 N/A physical interaction,two hybrid fragment pooling approach ComPPI
DGKZ POLR2M 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
DGKZ VHL 25348397 N/A physical interaction ComPPI
DGKZ PARD6A 25348397 N/A physical interaction ComPPI
DGKZ ARRB1 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DGKZ ARRB2 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DGKZ XPO1 25348397 N/A physical interaction ComPPI
DGKZ TP53 25348397 N/A physical interaction ComPPI
MAPK6 DGKZ 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DGKZ DMD 11352924 14525934 N/A experimental interaction detection HPRD
DGKZ POLR2M 14525934 16169070 N/A two hybrid HPRD
HNRNPM DGKZ 24234451 30021884 physical association cross-linking study IntAct
HRAS DGKZ 11257115 27898060 N/A N/A OmniPath
DGKZ HRAS 11257115 27898060 N/A N/A OmniPath
DGKZ RASGRP1 11257115 27898060 N/A N/A OmniPath
SNTG1 DGKZ 11163757 11352924 27898060 N/A N/A OmniPath

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