GENE:CDC6
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | CDC6 |
FullNmae | cell division cycle 6 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:1744 |
EnsembleID | ENSG00000094804 |
Uniprot | Q99741 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
CDC6 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
CDC6 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
CDC6 | GO:0000076,GO:0000079,GO:0000166,GO:0000922,GO:0003688,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0006270,GO:0007089,GO:0008156,GO:0008285,GO:0016887,GO:0019900,GO:0030071,GO:0032467,GO:0033314,GO:0045171,GO:0048146,GO:0051233,GO:0051301,GO:0051984,GO:0072686,GO:1904117,GO:1904385 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
CDC6 | hsa:990 | path:hsa04110 | Cell cycle - Homo sapiens (human) |
CDC6 | hsa:990 | path:hsa05207 | Chemical carcinogenesis - receptor activation - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
AR | CDC6 | 18541154 20610535 24583551 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
E2F4 | CDC6 | 17531812 17671431 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator,chromatin immunoprecipitation assay | TFlink |
ESR1 | CDC6 | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
ETS1 | CDC6 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
GATA2 | CDC6 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
MYC | CDC6 | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
YBX1 | CDC6 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
FOXP3 | CDC6 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
SMARCA4 | CDC6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | CDC6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | CDC6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOS | CDC6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | CDC6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
ARID3A | CDC6 | 23659165 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F1 | CDC6 | 18541154 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F3 | CDC6 | 18541154 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXM1 | CDC6 | 24583551 | trascriptional regulation,stimulation | inferred by curator | TFlink |
GATA1 | CDC6 | 22871742 | trascriptional regulation,stimulation | inferred by curator | TFlink |
MSC | CDC6 | 15213307 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS00000AA464 | CDC6 | 20304954 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS00001E0AEA | CDC6 | 17612493 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS00000CF1D2 | CDC6 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS00003D5391 | CDC6 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS00000EEE35 | CDC6 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS000027464B | CDC6 | 24532688 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS0000331800 | CDC6 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002B0920 | CDC6 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000003FD55 | CDC6 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00004AC389 | CDC6 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000016D2D4 | CDC6 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000075B13F | CDC6 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000012930C | CDC6 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002C02E4 | CDC6 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002FC5B0 | CDC6 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001A7F58 | CDC6 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
CDK2 | CDC6 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
PLK1 | CDC6 | 22135298 | phosphorylation | N/A | PhosphoSite |
CDC6 | CDKN1A | 25361965 | interaction type | N/A | PTMCode2 |
CDKN1A | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | CCNA1 | 25361965 | interaction type | N/A | PTMCode2 |
CCNA1 | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | CCNB1 | 25361965 | interaction type | N/A | PTMCode2 |
CCNB1 | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | CDKN2C | 25361965 | interaction type | N/A | PTMCode2 |
CDKN2C | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | HUWE1 | 25361965 | interaction type | N/A | PTMCode2 |
HUWE1 | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | MCM2 | 25361965 | interaction type | N/A | PTMCode2 |
MCM2 | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | CDK2 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | CCNA2 | 25361965 | interaction type | N/A | PTMCode2 |
CCNA2 | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | FBXW7 | 25361965 | interaction type | N/A | PTMCode2 |
FBXW7 | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | CCNB2 | 25361965 | interaction type | N/A | PTMCode2 |
CCNB2 | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | CCNL1 | 25361965 | interaction type | N/A | PTMCode2 |
CCNL1 | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | RPS27A | 25361965 | interaction type | N/A | PTMCode2 |
RPS27A | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | MCM7 | 25361965 | interaction type | N/A | PTMCode2 |
MCM7 | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | ATRIP | 25361965 | interaction type | N/A | PTMCode2 |
ATRIP | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | COPB2 | 25361965 | interaction type | N/A | PTMCode2 |
COPB2 | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | ATR | 25361965 | interaction type | N/A | PTMCode2 |
ATR | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | MCM10 | 25361965 | interaction type | N/A | PTMCode2 |
MCM10 | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | MYC | 25361965 | interaction type | N/A | PTMCode2 |
MYC | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | PCNA | 25361965 | interaction type | N/A | PTMCode2 |
PCNA | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | SUMO1 | 25361965 | interaction type | N/A | PTMCode2 |
SUMO1 | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
CDC6 | AKAP8L | 25361965 | interaction type | N/A | PTMCode2 |
AKAP8L | CDC6 | 25361965 | interaction type | N/A | PTMCode2 |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
ORC1 | CDC6 | 12912926 14525934 15232106 24234451 25348397 9566895 | N/A | experimental interaction detection,protein array,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
PCNA | CDC6 | 14525934 25348397 9566895 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD |
CDKN1A | CDC6 | 14525934 15232106 24234451 25241761 25348397 | physical association | experimental interaction detection,protein array,physical interaction,in vitro,proximity ligation assay | ComPPI,HPRD,IntAct |
CDK6 | CDC6 | 22094256 24234451 25348397 | phosphorylation reaction | physical interaction,protein kinase assay | ComPPI,IntAct |
BMI1 | CDC6 | 25348397 | N/A | physical interaction | ComPPI |
MCM6 | CDC6 | 23397142 24234451 25348397 | physical association | proximity ligation assay | ComPPI,IntAct |
MCM2 | CDC6 | 14525934 15232106 24234451 25348397 | N/A | experimental interaction detection,protein array,physical interaction,in vitro | ComPPI,HPRD,IntAct |
ORC6 | CDC6 | 14525934 15232106 24234451 25348397 | N/A | experimental interaction detection,protein array,physical interaction,in vitro | ComPPI,HPRD,IntAct |
TGFBR2 | CDC6 | 25348397 | N/A | physical interaction | ComPPI |
ATR | CDC6 | 25348397 | N/A | physical interaction | ComPPI |
FZR1 | CDC6 | 25348397 | N/A | physical interaction | ComPPI |
POLA1 | CDC6 | 25348397 | N/A | physical interaction | ComPPI |
MCM10 | CDC6 | 14525934 15232106 24234451 25348397 | N/A | experimental interaction detection,protein array,physical interaction,in vitro | ComPPI,HPRD,IntAct |
CDKN2A | CDC6 | 15232106 24234451 25348397 | N/A | protein array,physical interaction,in vitro | ComPPI,IntAct |
UBB | CDC6 | 10995389 24234451 25348397 | physical association | coimmunoprecipitation | ComPPI,IntAct |
RPS27A | CDC6 | 10995389 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
E2F1 | CDC6 | 23397142 24234451 25348397 | physical association | proximity ligation assay | ComPPI,IntAct |
CDC6 | PSKH1 | 14525934 25348397 9889196 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
CDC6 | MYC | 10899308 14525934 25348397 27898060 | N/A | affinity chromatography technology,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,OmniPath |
CDC6 | PPP2R3B | 10629059 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
CDC6 | ORC2 | 12614612 14525934 15232106 24234451 25348397 | N/A | two hybrid,experimental interaction detection,protein array,physical interaction,in vitro,two hybrid | ComPPI,HPRD,IntAct |
CDC6 | ORC3 | 14525934 15232106 24234451 25348397 | N/A | experimental interaction detection,protein array,physical interaction,in vitro | ComPPI,HPRD,IntAct |
CDC6 | CDT1 | 14525934 14672932 15232106 24234451 25348397 | physical association | experimental interaction detection,protein array,pull down,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
CDC6 | ORC5 | 14525934 15232106 24234451 25348397 | N/A | experimental interaction detection,protein array,physical interaction,in vitro | ComPPI,HPRD,IntAct |
CDC6 | AKAP8L | 25348397 | N/A | physical interaction,in vivo | ComPPI |
CDC6 | MCM7 | 10464337 12614612 14525934 23397142 24234451 25348397 | physical association | experimental interaction detection,physical interaction,in vivo,proximity ligation assay | ComPPI,HPRD,IntAct |
CDC6 | MCM3 | 15232106 24234451 25348397 | N/A | protein array,physical interaction,in vivo | ComPPI,IntAct |
CDC6 | PPP2R3A | 10629059 14525934 25348397 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD |
CDC6 | CDK2 | 10339564 14525934 25348397 9889196 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
CDC6 | CCNA2 | 14525934 25348397 9566895 9889196 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
CDC6 | MCM8 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | HUWE1 | 17567951 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
CDC6 | TERF1 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | ATM | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | ATRIP | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | KAT7 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | CCL2 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | CDC20 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | CDK4 | 22094256 24234451 25348397 | phosphorylation reaction | physical interaction,protein kinase assay | ComPPI,IntAct |
CDC6 | CDKN2A | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | CCNE1 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | CCNB1 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | CDK1 | 21041660 24234451 25348397 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
CDC6 | B3GALNT1 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
CDC6 | UBE2K | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
CDC6 | CDC14A | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | UBR1 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | TSPAN3 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | COLEC11 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | ISLR | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | PON2 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | NOP56 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
CDC6 | CCNF | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | LAMP2 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | IL20RA | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | TNFRSF1A | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | FAM131B | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | PROZ | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | MANSC1 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | PCDHB11 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | TNFRSF10A | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | LAMP3 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | BPNT1 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | GLMP | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | TNFRSF8 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | MAGEA10 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | PCDHGA5 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | HEY1 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | GRWD1 | 25348397 | N/A | physical interaction | ComPPI |
CDC6 | PLK1 | 21041660 24234451 25348397 | phosphorylation reaction,association,physical association | anti bait coimmunoprecipitation,pull down,phosphorylation reaction,physical interaction,protein kinase assay | ComPPI,IntAct |
CDC6 | TTC4 | 18320024 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,lexa b52 complementation | ComPPI,IntAct |
MAPK6 | CDC6 | 24234451 25348397 26972000 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
TANK | CDC6 | 24234451 30561431 | association | virotrap | IntAct |
KPNA2 | CDC6 | 18485366 27898060 | N/A | N/A | OmniPath |
PLK1 | CDC6 | 21041660 27898060 | stimulant | N/A | OmniPath |
GMNN | CDC6 | 15380092 27898060 | inhibition | N/A | OmniPath |
CDK2 | CDC6 | 10339564 14749377 16153703 18691976 19343071 20068231 23129444 24216307 27898060 9566895 9889196 | inhibition,stimulant | N/A | OmniPath |