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GENE：ADCY3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ADCY3
FullNmae adenylate cyclase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:234
EnsembleID ENSG00000138031
Uniprot O60266

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ADCY3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ADCY3 GO:0004016,GO:0004016,GO:0005516,GO:0005524,GO:0005737,GO:0005794,GO:0005886,GO:0005886,GO:0005929,GO:0006171,GO:0006171,GO:0007165,GO:0007189,GO:0007189,GO:0007338,GO:0007340,GO:0007608,GO:0008355,GO:0016020,GO:0016020,GO:0030317,GO:0035556,GO:0046872,GO:0060170,GO:1904322

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ADCY3 hsa:109 path:hsa00230 Purine metabolism - Homo sapiens (human)
ADCY3 hsa:109 path:hsa01100 Metabolic pathways - Homo sapiens (human)
ADCY3 hsa:109 path:hsa01522 Endocrine resistance - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04540 Gap junction - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04611 Platelet activation - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04713 Circadian entrainment - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04714 Thermogenesis - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04727 GABAergic synapse - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04740 Olfactory transduction - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04911 Insulin secretion - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04913 Ovarian steroidogenesis - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04916 Melanogenesis - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04918 Thyroid hormone synthesis - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04927 Cortisol synthesis and secretion - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04934 Cushing syndrome - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04962 Vasopressin-regulated water reabsorption - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04970 Salivary secretion - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04971 Gastric acid secretion - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04972 Pancreatic secretion - Homo sapiens (human)
ADCY3 hsa:109 path:hsa04976 Bile secretion - Homo sapiens (human)
ADCY3 hsa:109 path:hsa05032 Morphine addiction - Homo sapiens (human)
ADCY3 hsa:109 path:hsa05110 Vibrio cholerae infection - Homo sapiens (human)
ADCY3 hsa:109 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
ADCY3 hsa:109 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
ADCY3 hsa:109 path:hsa05200 Pathways in cancer - Homo sapiens (human)
ADCY3 hsa:109 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
ADCY3 hsa:109 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ESR1 ADCY3 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ADCY3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ADCY3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 ADCY3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TAL1 ADCY3 20028976 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ADCY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ADCY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ADCY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ADCY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ADCY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ADCY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ADCY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 ADCY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ADCY3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000FC8EB ADCY3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000002103A ADCY3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000070B1D ADCY3 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
ADCY3 CAMK2B 25361965 interaction type N/A PTMCode2
CAMK2B ADCY3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LGALS3 ADCY3 25348397 N/A physical interaction ComPPI
KCNA5 ADCY3 25348397 N/A physical interaction ComPPI
HNRNPL ADCY3 25348397 N/A physical interaction ComPPI
CAMK2G ADCY3 25348397 N/A in vivo ComPPI
ADRB2 ADCY3 25348397 N/A physical interaction ComPPI
SLC4A8 ADCY3 25348397 N/A physical interaction ComPPI
ADCY3 STOML3 12122055 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ADCY3 POPDC2 25348397 N/A physical interaction ComPPI
ADCY3 ANKMY2 25348397 N/A physical interaction ComPPI
ADCY3 ASIC4 25348397 N/A physical interaction ComPPI
ADCY3 CNGA3 25348397 N/A physical interaction ComPPI
ADCY3 IL17RC 25348397 N/A physical interaction ComPPI
ADCY3 PCDHGA5 25348397 N/A physical interaction ComPPI
ADCY3 CD79B 25348397 N/A physical interaction ComPPI
ADCY3 IZUMO1 25348397 N/A physical interaction ComPPI
ADCY3 SLC17A2 25348397 N/A physical interaction ComPPI
ADCY3 MTNR1B 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
SYK ADCY3 27898060 8798667 9768837 N/A N/A OmniPath
CAMK2G ADCY3 27898060 8798667 9768837 inhibition N/A OmniPath

Visualization










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