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GENE：CTNNA1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CTNNA1
FullNmae catenin alpha 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2509
EnsembleID ENSG00000044115
Uniprot P35221

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CTNNA1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CTNNA1 entotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CTNNA1 entotic_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CTNNA1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CTNNA1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CTNNA1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CTNNA1 GO:0001541,GO:0001669,GO:0003723,GO:0005198,GO:0005515,GO:0005829,GO:0005886,GO:0005886,GO:0005911,GO:0005912,GO:0005915,GO:0005925,GO:0007155,GO:0007163,GO:0007224,GO:0007229,GO:0007405,GO:0007406,GO:0008013,GO:0008013,GO:0008104,GO:0008584,GO:0014704,GO:0015629,GO:0016264,GO:0016342,GO:0016342,GO:0016477,GO:0016600,GO:0017166,GO:0030027,GO:0030054,GO:0031103,GO:0042475,GO:0042802,GO:0043231,GO:0043297,GO:0043627,GO:0045295,GO:0045296,GO:0045296,GO:0045880,GO:0051015,GO:0071681,GO:0090136,GO:0097192,GO:0098609,GO:1900181,GO:2000146,GO:2001045,GO:2001240,GO:2001241

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CTNNA1 hsa:1495 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
CTNNA1 hsa:1495 path:hsa04520 Adherens junction - Homo sapiens (human)
CTNNA1 hsa:1495 path:hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
CTNNA1 hsa:1495 path:hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)
CTNNA1 hsa:1495 path:hsa05200 Pathways in cancer - Homo sapiens (human)
CTNNA1 hsa:1495 path:hsa05213 Endometrial cancer - Homo sapiens (human)
CTNNA1 hsa:1495 path:hsa05226 Gastric cancer - Homo sapiens (human)
CTNNA1 hsa:1495 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDH1 CTNNA1 11801604 16219695 23180781 9700170 physical association anti tag coimmunoprecipitation InnateDB
PIK3R1 CTNNA1 16219695 23180781 physical association anti tag coimmunoprecipitation InnateDB
CTNNB1 CTNNA1 15492215 16219695 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDH24 CTNNA1 12734196 23180781 physical association anti tag coimmunoprecipitation InnateDB
ERBB2 CTNNA1 23180781 7999105 physical association anti tag coimmunoprecipitation InnateDB
SUZ12 CTNNA1 20371743 23180781 physical association anti tag coimmunoprecipitation InnateDB
EZH2 CTNNA1 20371743 23180781 physical association anti tag coimmunoprecipitation InnateDB
CTNNA1 CEBPA 20371743 23180781 physical association anti tag coimmunoprecipitation InnateDB
APP CTNNA1 21832049 23180781 physical association protein array InnateDB
CTNNA1 CTNNA1 23431053 26467481 bind,down-regulates N/A Signor

Source Target Pmid Interactiontype Methods Database
AR CTNNA1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA3 CTNNA1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CTNNA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CTNNA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CTNNA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CTNNA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CTNNA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 CTNNA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CTNNA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CTNNA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 CTNNA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CTNNA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CTNNA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 CTNNA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CTNNA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 CTNNA1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000EC1BE CTNNA1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C3AC1 CTNNA1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004E008F CTNNA1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 CTNNA1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 CTNNA1 22135298 phosphorylation N/A PhosphoSite
APC CTNNA1 25361965 interaction type N/A PTMCode2
CTNNA1 APC 25361965 interaction type N/A PTMCode2
CTNNA1 JUP 25361965 interaction type N/A PTMCode2
JUP CTNNA1 25361965 interaction type N/A PTMCode2
CTNNA1 CDH5 25361965 interaction type N/A PTMCode2
CDH5 CTNNA1 25361965 interaction type N/A PTMCode2
CTNNA1 CTNNB1 25361965 interaction type N/A PTMCode2
CTNNB1 CTNNA1 25361965 interaction type N/A PTMCode2
CTNNA1 CDH4 25361965 interaction type N/A PTMCode2
CDH4 CTNNA1 25361965 interaction type N/A PTMCode2
CTNNA1 PARD3 25361965 interaction type N/A PTMCode2
PARD3 CTNNA1 25361965 interaction type N/A PTMCode2
CTNNA1 LIMA1 25361965 interaction type N/A PTMCode2
LIMA1 CTNNA1 25361965 interaction type N/A PTMCode2
CTNNA1 CTNND1 25361965 interaction type N/A PTMCode2
CTNND1 CTNNA1 25361965 interaction type N/A PTMCode2
EGFR CTNNA1 25361965 interaction type N/A PTMCode2
CTNNA1 EGFR 25361965 interaction type N/A PTMCode2
CDH1 CTNNA1 25361965 interaction type N/A PTMCode2
CTNNA1 CDH1 25361965 interaction type N/A PTMCode2
CDH2 CTNNA1 25361965 interaction type N/A PTMCode2
CTNNA1 CDH2 25361965 interaction type N/A PTMCode2
CDH3 CTNNA1 25361965 interaction type N/A PTMCode2
CTNNA1 CDH3 25361965 interaction type N/A PTMCode2
VCL CTNNA1 25361965 interaction type N/A PTMCode2
CTNNA1 VCL 25361965 interaction type N/A PTMCode2
CTNNA1 CTNNA1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAPRE1 CTNNA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBE2I CTNNA1 25348397 N/A physical interaction ComPPI
SNW1 CTNNA1 20467437 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CDC5L CTNNA1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FBP2 CTNNA1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
FBP1 CTNNA1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CDH15 CTNNA1 14525934 25348397 9168809 N/A experimental interaction detection,in vitro ComPPI,HPRD
LRATD2 CTNNA1 12477722 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
VCP CTNNA1 25348397 N/A physical interaction ComPPI
CTNNBIP1 CTNNA1 25348397 N/A physical interaction ComPPI
MCM2 CTNNA1 25348397 N/A physical interaction ComPPI
CTNND1 CTNNA1 25348397 N/A physical interaction ComPPI
SMAD1 CTNNA1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
HRAS CTNNA1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
RACGAP1 CTNNA1 22750944 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ARAF CTNNA1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
JUN CTNNA1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
COPS5 CTNNA1 25348397 N/A physical interaction ComPPI
CTBP1 CTNNA1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
OSBP CTNNA1 25348397 N/A physical interaction ComPPI
SFRP2 CTNNA1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SLC9A3R2 CTNNA1 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
JUP CTNNA1 14525934 20936779 24234451 25241761 25348397 7650039 7890674 9110993 physical association experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
DLD CTNNA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ACTN1 CTNNA1 14525934 24234451 25241761 25348397 7790378 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
NTRK1 CTNNA1 25348397 N/A physical interaction ComPPI
APC CTNNA1 20936779 24234451 25241761 25348397 26496610 association,physical association anti tag coimmunoprecipitation,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,proximity ligation assay ComPPI,IntAct
CDH1 CTNNA1 16212417 19016843 22750944 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,surface plasmon resonance,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,IntAct
CDH5 CTNNA1 12003790 14525934 25348397 N/A experimental interaction detection,physical interaction,imaging technique,in vivo ComPPI,HPRD
PKD1 CTNNA1 11274246 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
BTRC CTNNA1 25348397 N/A physical interaction ComPPI
AXIN1 CTNNA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ILK CTNNA1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA5 CTNNA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP2K1 CTNNA1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
NFKBIA CTNNA1 24234451 24509793 25348397 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
CSNK2A1 CTNNA1 25348397 N/A physical interaction ComPPI
XRCC6 CTNNA1 25348397 N/A physical interaction ComPPI
VCL CTNNA1 14525934 24234451 25348397 26496610 9700171 association anti tag coimmunoprecipitation,experimental interaction detection,molecular sieving,physical interaction,comigration in non denaturing gel electrophoresis,in vitro,in vivo ComPPI,HPRD,IntAct
CFTR CTNNA1 25348397 N/A physical interaction ComPPI
GSK3A CTNNA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SPTAN1 CTNNA1 11069925 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
PARD3 CTNNA1 17057644 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RELA CTNNA1 24234451 24509793 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ZNF510 CTNNA1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
PDHA1 CTNNA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ANG CTNNA1 24234451 25348397 28777577 association anti bait coimmunoprecipitation ComPPI,IntAct
ECT2 CTNNA1 22750944 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CUL2 CTNNA1 25348397 N/A physical interaction ComPPI
ARRB2 CTNNA1 17620599 24234451 25241761 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,proximity ligation assay ComPPI,IntAct
DLG1 CTNNA1 14525934 25348397 9512503 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SPTBN1 CTNNA1 25348397 N/A physical interaction ComPPI
EGFR CTNNA1 15657067 24189400 24234451 25241761 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification,proximity ligation assay ComPPI,IntAct
TUBA1A CTNNA1 24234451 25348397 27291054 association pull down ComPPI,IntAct
CTTN CTNNA1 25348397 N/A physical interaction ComPPI
MYO7A CTNNA1 25348397 N/A physical interaction ComPPI
YAP1 CTNNA1 21376238 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CTNNB1 CTNNA1 12640114 14525934 17098867 24234451 24509793 25348397 26496610 7706414 9110993 9512503 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
HSPH1 CTNNA1 25348397 N/A physical interaction ComPPI
UBE2A CTNNA1 25348397 N/A physical interaction ComPPI
AJUBA CTNNA1 12417594 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CA9 CTNNA1 14525934 14567991 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CTNNA1 CDH2 12604612 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CTNNA1 CDH3 10381631 14525934 1924379 25348397 8227214 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CTNNA1 TJP2 10026224 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CTNNA1 PSEN1 10635315 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CTNNA1 PTPN14 25348397 N/A physical interaction ComPPI
CTNNA1 AFDN 23750010 24234451 25348397 colocalization physical interaction,confocal microscopy ComPPI,IntAct
CTNNA1 VEZT 25348397 N/A physical interaction ComPPI
CTNNA1 ZGPAT 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CTNNA1 RYK 25348397 N/A physical interaction ComPPI
CTNNA1 SIRT7 25348397 N/A physical interaction ComPPI
CTNNA1 ARMC8 18215130 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CTNNA1 APP 25348397 N/A physical interaction ComPPI
CTNNA1 CTNNA3 25348397 N/A physical interaction ComPPI
CTNNA1 GARS1 25348397 N/A physical interaction ComPPI
CTNNA1 SEC23A 25348397 N/A physical interaction ComPPI
CTNNA1 USP11 25348397 N/A physical interaction ComPPI
CTNNA1 EIF4B 25348397 N/A physical interaction ComPPI
CTNNA1 PRMT3 25348397 N/A physical interaction ComPPI
CTNNA1 FBXW11 25348397 N/A physical interaction ComPPI
CTNNA1 OBSL1 25348397 N/A physical interaction ComPPI
CTNNA1 CCDC8 25348397 N/A physical interaction ComPPI
CTNNA1 UNK 25348397 N/A physical interaction ComPPI
CTNNA1 DMD 25348397 N/A physical interaction ComPPI
CTNNA1 HERC2 25348397 N/A physical interaction ComPPI
CTNNA1 HERC2P3 25348397 N/A physical interaction ComPPI
CTNNA1 CFAP298 25348397 N/A physical interaction ComPPI
CTNNA1 IQSEC1 25348397 N/A physical interaction ComPPI
CTNNA1 CTDSPL 25348397 N/A physical interaction ComPPI
CTNNA1 CDH8 25348397 N/A physical interaction ComPPI
CTNNA1 SAPCD1 25348397 N/A physical interaction ComPPI
CTNNA1 SLAMF7 25348397 N/A physical interaction ComPPI
CTNNA1 NEK4 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
CTNNA1 MTNR1A 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
CTNNA1 MTNR1B 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
CTNNA1 HSD17B10 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
CTNNA1 TRIM25 25348397 N/A physical interaction ComPPI
CTNNA1 BRCA1 25348397 N/A physical interaction ComPPI
CTNNA1 TES 25348397 N/A physical interaction ComPPI
CTNNA1 LIMA1 18093941 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CTNNA1 CEP350 24234451 25348397 25764135 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
CTNNA1 PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CTNNA1 E2F3 22157815 24234451 25348397 association pull down ComPPI,IntAct
CTNNA1 MCM7 23764002 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CTNNA1 AKT1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CTNNA1 ALDOB 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CTNNA1 CTSV 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CTNNA1 FRAT2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CTNNA1 HSD17B3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CTNNA1 CCDC180 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CTNNA1 NANS 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CTNNA1 SFRP4 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CTNNA1 STX17 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CTNNA1 TDRD7 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CTNNA1 ZNF189 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CTNNA1 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
CTNNA1 LAMP1 24234451 25348397 29568061 association pull down ComPPI,IntAct
XPO7 CTNNA1 25348397 N/A physical interaction ComPPI
BAAT CTNNA1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
OBI1 CTNNA1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
TJP1 CTNNA1 14525934 9214391 N/A experimental interaction detection HPRD
CTNNA1 CTNNA1 23292143 24234451 N/A molecular sieving,x-ray crystallography,comigration in non denaturing gel electrophoresis IntAct
F2RL1 CTNNA1 24234451 28298427 physical association ubiquitin reconstruction IntAct
L1TD1 CTNNA1 24234451 25702638 association anti bait coimmunoprecipitation IntAct
CDH1 CTNNA1 10381631 11226248 11801604 11960376 16212417 16219695 24336504 27898060 7542250 8227214 9233779 9326449 9700170 stimulant N/A OmniPath
CTNNA1 YAP1 23431053 27898060 inhibition N/A OmniPath
PTPN11 CTNNA1 16767162 27898060 inhibition N/A OmniPath
CSNK2A1 CTNNA1 19941816 20093040 27898060 inhibition,stimulant N/A OmniPath

Visualization










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