Gene Information gene info

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GENE：IL11

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL11
FullNmae interleukin 11
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5966
EnsembleID ENSG00000095752
Uniprot P20809

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL11 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL11 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IL11 GO:0005125,GO:0005125,GO:0005142,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0008083,GO:0008083,GO:0008283,GO:0008284,GO:0008284,GO:0030183,GO:0030219,GO:0033138,GO:0038154,GO:0043410,GO:0043410,GO:0045444,GO:0045944,GO:0046888,GO:0050731

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL11 hsa:3589 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL11 hsa:3589 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IL11 hsa:3589 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
IL11 hsa:3589 path:hsa05323 Rheumatoid arthritis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL6ST IL11 23180781 9560294 physical association anti tag coimmunoprecipitation InnateDB
IL11 MAGEA11 16189514 23180781 physical association two hybrid InnateDB
IL11RA IL11 23180781 8940087 physical association anti tag coimmunoprecipitation InnateDB
IL11 IL11 23180781 8940087 physical association anti tag coimmunoprecipitation InnateDB
IL11 JUN 23180781 9488674 physical association electrophoretic mobility supershift assay InnateDB
JUND IL11 23180781 9488674 physical association electrophoretic mobility supershift assay InnateDB
FOSL1 IL11 23180781 9488674 physical association electrophoretic mobility supershift assay InnateDB
FOSL2 IL11 23180781 9488674 physical association electrophoretic mobility supershift assay InnateDB
IL11 IL11RA 12740032 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
EGR1 IL11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HOXA10 IL11 20478621 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 IL11 23224145 trascriptional regulation,stimulation inferred by curator TFlink
TP53 IL11 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000029D9F1 IL11 22629385 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000044FD7 IL11 22629385 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00001EE123 IL11 22629385 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000029D9F1 IL11 21282569 22629385 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,miRNA interference luciferase reporter assay TarBase
URS0000044FD7 IL11 22629385 24039954 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001EE123 IL11 22629385 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
IL11 IL11RA 25361965 interaction type N/A PTMCode2
IL11RA IL11 25361965 interaction type N/A PTMCode2
IL11 IL6ST 25361965 interaction type N/A PTMCode2
IL6ST IL11 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
S100P IL11 24234451 25348397 26551460 N/A cross-linking study,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
IL6ST IL11 25348397 N/A experimental interaction detection,physical interaction ComPPI
UBQLN2 IL11 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM25 IL11 25348397 N/A physical interaction ComPPI
MAGEA11 IL11 14525934 16189514 24234451 25348397 physical association physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
IL11RA IL11 24234451 25348397 26551460 N/A coimmunoprecipitation,surface plasmon resonance,physical interaction,surface plasmon resonance array ComPPI,IntAct
IL11 IL6ST 27898060 8360477 9143707 9560294 stimulant N/A OmniPath
IL11 IL11RA 10504396 10948192 12740032 27898060 7670098 8940087 stimulant N/A OmniPath
IL11 MAGEA11 16189514 25416956 27898060 N/A N/A OmniPath

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