GENE：KLF12
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | KLF12 |
| FullNmae | KLF transcription factor 12 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6346 |
| EnsembleID | ENSG00000118922 |
| Uniprot | Q9Y4X4 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| KLF12 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| KLF12 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| KLF12 | GO:0000122,GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001227,GO:0003677,GO:0003700,GO:0005515,GO:0005654,GO:0005829,GO:0006357,GO:0046872,GO:1990837 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | KLF12 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | KLF12 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| TP63 | KLF12 | 17521434 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | KLF12 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | KLF12 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | KLF12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | KLF12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | KLF12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | KLF12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | KLF12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | KLF12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | KLF12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | KLF12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | KLF12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | KLF12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | KLF12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TFAP2A | KLF12 | 10704285 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00001CC864 | KLF12 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000032BDF4 | KLF12 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000046CDA6 | KLF12 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F31F4 | KLF12 | 20371350 22012620 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EED18 | KLF12 | 25416803 26183718 | mrna cleavage,inhibition | experimental interaction detection,nucleotide sequence identification,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000003E1A9 | KLF12 | 25416803 27292025 28095864 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
| URS00001E3523 | KLF12 | 25416803 27468717 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000008DA94 | KLF12 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| FHL3 | KLF12 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| EHMT2 | KLF12 | 14525934 16189514 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| FHL2 | KLF12 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CTBP1 | KLF12 | 11373277 14525934 24722188 25348397 25416956 27898060 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| TRIM25 | KLF12 | 25348397 | N/A | physical interaction | ComPPI |
| DYNLT1 | KLF12 | 25348397 | N/A | physical interaction | ComPPI |
| DNMT3L | KLF12 | 25348397 | N/A | physical interaction | ComPPI |
| KLF12 | APP | 25348397 | N/A | physical interaction | ComPPI |
| KLF12 | THAP1 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| KLF12 | IDO2 | 25348397 | N/A | physical interaction | ComPPI |
| KLF12 | TCTE1 | 24234451 25348397 26638075 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| EHMT2 | KLF12 | 16189514 18438403 27898060 | N/A | N/A | OmniPath |