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GENE：MECP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MECP2
FullNmae methyl-CpG binding protein 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6990
EnsembleID ENSG00000169057
Uniprot P51608

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MECP2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MECP2 GO:0000122,GO:0000400,GO:0000792,GO:0000792,GO:0001662,GO:0001666,GO:0001964,GO:0001976,GO:0002087,GO:0003676,GO:0003677,GO:0003682,GO:0003700,GO:0003714,GO:0003723,GO:0003729,GO:0005515,GO:0005615,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005813,GO:0005829,GO:0006020,GO:0006349,GO:0006541,GO:0006576,GO:0007052,GO:0007219,GO:0007416,GO:0007507,GO:0007585,GO:0007616,GO:0008104,GO:0008211,GO:0008284,GO:0008327,GO:0008344,GO:0008542,GO:0009791,GO:0010212,GO:0010288,GO:0010385,GO:0010385,GO:0010467,GO:0010629,GO:0010971,GO:0014003,GO:0014009,GO:0016358,GO:0016525,GO:0019230,GO:0019233,GO:0019904,GO:0021510,GO:0021549,GO:0021591,GO:0021740,GO:0021756,GO:0021766,GO:0021772,GO:0021794,GO:0021987,GO:0031490,GO:0031507,GO:0031915,GO:0032048,GO:0032355,GO:0035176,GO:0035197,GO:0035865,GO:0042220,GO:0042551,GO:0042802,GO:0042826,GO:0043524,GO:0043537,GO:0045322,GO:0045892,GO:0045944,GO:0046470,GO:0048286,GO:0048712,GO:0050432,GO:0050807,GO:0051151,GO:0051570,GO:0051707,GO:0060079,GO:0060090,GO:0060252,GO:0060291,GO:0060999,GO:0061000,GO:0071317,GO:0090063,GO:0090327,GO:0098794,GO:0098978,GO:0099191,GO:0099611,GO:0140693,GO:1901953,GO:1901956,GO:1903860,GO:1903861,GO:1903941,GO:1905492,GO:1905643,GO:1990841,GO:2000635,GO:2000820

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PPARG MECP2 21151932 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR MECP2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 MECP2 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA3 MECP2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MECP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MECP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MECP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MECP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MECP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MECP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MECP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 MECP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MECP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MECP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MECP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MECP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MEF2C MECP2 20513142 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC MECP2 19296470 rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000028BB8 MECP2 \N rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000338542 MECP2 19897480 20388499 rna interference,inhibition array technology,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS000006FDD4 MECP2 N/A 14697198 18460397 rna interference,inhibition array technology,experimental interaction detection,miRNA interference luciferase reporter assay miRSponge
URS00001AFC71 MECP2 20020497 rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS0000338542 MECP2 19897480 20388499 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS000040EE1D MECP2 16331254 25416803 mrna cleavage,inhibition array technology,northern blot TarBase
URS000006FDD4 MECP2 14697198 18460397 21572407 22473208 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,clip,miRNA interference luciferase reporter assay TarBase
URS00003380CC MECP2 19296470 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001AFC71 MECP2 20020497 25416803 25766675 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000521626 MECP2 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS000048BA36 MECP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC MECP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000007FBA MECP2 23667495 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS000018C928 MECP2 23667495 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS0000065D58 MECP2 23960241 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000105D19 MECP2 24657437 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunocytochemistry,miRNA interference luciferase reporter assay TarBase
URS0000042E1F MECP2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 MECP2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00005DEC41 MECP2 22012620 23446348 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000BF7F9 MECP2 22012620 23446348 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000157FBE MECP2 22012620 23446348 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000075BDAA MECP2 23446348 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000011DF MECP2 22012620 23446348 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000017CCCB MECP2 22012620 23446348 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000259AE4 MECP2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000061E50F MECP2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000040780F MECP2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 MECP2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE MECP2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA MECP2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 MECP2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 MECP2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 MECP2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 MECP2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00003003B4 MECP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC MECP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000052EA98 MECP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000277201 MECP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 MECP2 25416803 27245166 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002EF20A MECP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000059EB31 MECP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000006B702 MECP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005485E8 MECP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000202460 MECP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000054DF42 MECP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000209F04 MECP2 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRPF40B MECP2 25361965 interaction type N/A PTMCode2
MECP2 PRPF40B 25361965 interaction type N/A PTMCode2
CDKL5 MECP2 25361965 interaction type N/A PTMCode2
MECP2 CDKL5 25361965 interaction type N/A PTMCode2
SMARCA2 MECP2 25361965 interaction type N/A PTMCode2
MECP2 SMARCA2 25361965 interaction type N/A PTMCode2
SPI1 MECP2 25361965 interaction type N/A PTMCode2
MECP2 SPI1 25361965 interaction type N/A PTMCode2
ATRX MECP2 25361965 interaction type N/A PTMCode2
MECP2 ATRX 25361965 interaction type N/A PTMCode2
SMARCE1 MECP2 25361965 interaction type N/A PTMCode2
MECP2 SMARCE1 25361965 interaction type N/A PTMCode2
SUV39H1 MECP2 25361965 interaction type N/A PTMCode2
MECP2 SUV39H1 25361965 interaction type N/A PTMCode2
SMARCB1 MECP2 25361965 interaction type N/A PTMCode2
MECP2 SMARCB1 25361965 interaction type N/A PTMCode2
LBR MECP2 25361965 interaction type N/A PTMCode2
MECP2 LBR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SMARCE1 MECP2 25348397 N/A physical interaction ComPPI
KPNA3 MECP2 25348397 N/A physical interaction ComPPI
DDX21 MECP2 25348397 N/A physical interaction ComPPI
KPNA4 MECP2 25348397 N/A physical interaction ComPPI
CDC42 MECP2 25348397 N/A physical interaction ComPPI
FXR2 MECP2 25348397 N/A physical interaction ComPPI
H2BC4 MECP2 25348397 N/A physical interaction ComPPI
GTF2B MECP2 25348397 N/A physical interaction ComPPI
AIM2 MECP2 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
RPL10A MECP2 25348397 N/A physical interaction ComPPI
H4C1 MECP2 25348397 N/A physical interaction ComPPI
SP1 MECP2 15109260 20385708 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CBX1 MECP2 25348397 N/A physical interaction ComPPI
SPI1 MECP2 25348397 N/A physical interaction ComPPI
JUN MECP2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
MYBBP1A MECP2 25348397 N/A physical interaction ComPPI
HDAC3 MECP2 23770565 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HIRA MECP2 25348397 N/A physical interaction ComPPI
NCOR1 MECP2 11441023 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TAF1A MECP2 25348397 N/A physical interaction ComPPI
PRPF40A MECP2 14525934 25348397 9171351 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
YBX1 MECP2 16251272 22615490 25348397 27898060 N/A physical interaction ComPPI,OmniPath
EIF2AK2 MECP2 25348397 N/A physical interaction ComPPI
ITGB3BP MECP2 25348397 N/A physical interaction ComPPI
SIN3A MECP2 10773092 11441023 14525934 14593184 15322089 22615490 23770565 24234451 25348397 27898060 9620779 9620804 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct,OmniPath
PLK1 MECP2 25348397 N/A physical interaction ComPPI
METAP2 MECP2 25348397 N/A physical interaction ComPPI
PPARG MECP2 25348397 N/A physical interaction ComPPI
HMGB1 MECP2 11748221 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MKI67 MECP2 24234451 25348397 26949251 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BAZ1A MECP2 25348397 N/A physical interaction ComPPI
BLM MECP2 25348397 N/A physical interaction ComPPI
H2BC21 MECP2 25348397 N/A physical interaction ComPPI
SUV39H1 MECP2 25348397 N/A physical interaction ComPPI
SMARCB1 MECP2 14525934 1569166 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
SP3 MECP2 25348397 N/A physical interaction ComPPI
RBAK MECP2 25348397 N/A physical interaction ComPPI
NSD1 MECP2 25348397 N/A physical interaction ComPPI
RPL12 MECP2 25348397 N/A physical interaction ComPPI
RPLP2 MECP2 25348397 N/A physical interaction ComPPI
YY1 MECP2 20504995 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SOX2 MECP2 25348397 N/A physical interaction ComPPI
CBX5 MECP2 17698499 22615490 25348397 27898060 N/A physical interaction ComPPI,OmniPath
RPL7A MECP2 25348397 N/A physical interaction ComPPI
H3C15 MECP2 25348397 N/A physical interaction ComPPI
CEBPZ MECP2 25348397 N/A physical interaction ComPPI
XPC MECP2 25348397 N/A physical interaction ComPPI
HIPK2 MECP2 19820693 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
RIOX2 MECP2 25348397 N/A physical interaction ComPPI
SMC3 MECP2 25348397 N/A physical interaction ComPPI
TAF1B MECP2 25348397 N/A physical interaction ComPPI
TAF1C MECP2 25348397 N/A physical interaction ComPPI
MECP2 SKI 11441023 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MECP2 RCOR1 25348397 N/A physical interaction ComPPI
MECP2 DNMT1 25348397 N/A physical interaction ComPPI
MECP2 HDAC1 25348397 N/A physical interaction ComPPI
MECP2 PRPF40B 25348397 N/A physical interaction ComPPI
MECP2 SMARCA2 14525934 15696166 20093853 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,cross-linking study,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct,OmniPath
MECP2 RBPJ 16763620 24234451 25348397 25609649 27898060 association physical interaction,tandem affinity purification ComPPI,IntAct,OmniPath
MECP2 LBR 19331822 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MECP2 CDKL5 15917271 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MECP2 TERF2 25348397 N/A physical interaction ComPPI
MECP2 ELAVL1 25348397 N/A physical interaction ComPPI
MECP2 CBX3 25348397 N/A physical interaction ComPPI
MECP2 H2AC20 25348397 N/A physical interaction ComPPI
MECP2 CAT 25348397 N/A physical interaction ComPPI
MECP2 HPDL 25348397 N/A physical interaction ComPPI
MECP2 SOX18 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MECP2 HECW2 25348397 N/A physical interaction ComPPI
MECP2 RNF4 25348397 N/A physical interaction ComPPI
MECP2 H2BC11 25348397 N/A physical interaction ComPPI
MECP2 AP4S1 25348397 N/A physical interaction ComPPI
MECP2 EXOSC4 25348397 N/A physical interaction ComPPI
MECP2 CHMP4B 25348397 N/A physical interaction ComPPI
MECP2 MACROH2A1 24234451 25348397 25417162 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MECP2 CREB1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MECP2 MAX 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
MECP2 TEAD2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MECP2 FOXC1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MECP2 FOXE1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MECP2 FOXI2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MECP2 DNMT3L 25348397 N/A physical interaction ComPPI
MECP2 H2BC18 25348397 N/A physical interaction ComPPI
MECP2 NOL8 25348397 N/A physical interaction ComPPI
MECP2 URB1 25348397 N/A physical interaction ComPPI
MECP2 C18ORF21 25348397 N/A physical interaction ComPPI
MECP2 CENPV 25348397 N/A physical interaction ComPPI
MECP2 URB2 25348397 N/A physical interaction ComPPI
MECP2 H1-6 25348397 N/A physical interaction ComPPI
MECP2 TWNK 25348397 N/A physical interaction ComPPI
MECP2 PDCD11 25348397 N/A physical interaction ComPPI
MECP2 DDX51 25348397 N/A physical interaction ComPPI
MECP2 SRBD1 25348397 N/A physical interaction ComPPI
MECP2 TFB1M 25348397 N/A physical interaction ComPPI
MECP2 ZNF800 25348397 N/A physical interaction ComPPI
MECP2 GTPBP10 25348397 N/A physical interaction ComPPI
MECP2 TRIP12 25348397 N/A physical interaction ComPPI
MECP2 CHMP1A 25348397 N/A physical interaction ComPPI
MECP2 NEPRO 25348397 N/A physical interaction ComPPI
MECP2 TEX10 25348397 N/A physical interaction ComPPI
MECP2 TRMT1L 25348397 N/A physical interaction ComPPI
MECP2 GTPBP4 25348397 N/A physical interaction ComPPI
MECP2 ZCCHC17 25348397 N/A physical interaction ComPPI
MECP2 RPL13 25348397 N/A physical interaction ComPPI
MECP2 WDR36 25348397 N/A physical interaction ComPPI
MECP2 PWP2 25348397 N/A physical interaction ComPPI
MECP2 NOP2 25348397 N/A physical interaction ComPPI
MECP2 DDX54 25348397 N/A physical interaction ComPPI
MECP2 GNL2 25348397 N/A physical interaction ComPPI
MECP2 DGCR8 25348397 N/A physical interaction ComPPI
MECP2 RPL18 25348397 N/A physical interaction ComPPI
MECP2 FCF1 25348397 N/A physical interaction ComPPI
MECP2 RPS8 25348397 N/A physical interaction ComPPI
MECP2 DDX31 25348397 N/A physical interaction ComPPI
MECP2 DDX24 25348397 N/A physical interaction ComPPI
MECP2 NOL6 25348397 N/A physical interaction ComPPI
MECP2 RPL8 25348397 N/A physical interaction ComPPI
MECP2 RPP40 25348397 N/A physical interaction ComPPI
MECP2 NOC2L 25348397 N/A physical interaction ComPPI
MECP2 RPF2 25348397 N/A physical interaction ComPPI
MECP2 ZNF483 25348397 N/A physical interaction ComPPI
MECP2 NVL 25348397 N/A physical interaction ComPPI
MECP2 LENG8 25348397 N/A physical interaction ComPPI
MECP2 NAT10 25348397 N/A physical interaction ComPPI
MECP2 SRSF8 25348397 N/A physical interaction ComPPI
MECP2 RPL3 25348397 N/A physical interaction ComPPI
MECP2 ESF1 25348397 N/A physical interaction ComPPI
MECP2 RPL36 25348397 N/A physical interaction ComPPI
MECP2 BBX 25348397 N/A physical interaction ComPPI
MECP2 NKAPD1 25348397 N/A physical interaction ComPPI
MECP2 BRIX1 25348397 N/A physical interaction ComPPI
MECP2 RPL32 25348397 N/A physical interaction ComPPI
MECP2 RPL29 25348397 N/A physical interaction ComPPI
MECP2 RRP1B 25348397 N/A physical interaction ComPPI
MECP2 DDX56 25348397 N/A physical interaction ComPPI
MECP2 ZNF354A 25348397 N/A physical interaction ComPPI
MECP2 RBM28 25348397 N/A physical interaction ComPPI
MECP2 RPL26L1 25348397 N/A physical interaction ComPPI
MECP2 RPL15 25348397 N/A physical interaction ComPPI
MECP2 RRP8 25348397 N/A physical interaction ComPPI
MECP2 NLE1 25348397 N/A physical interaction ComPPI
MECP2 RPL27 25348397 N/A physical interaction ComPPI
MECP2 RPL5 25348397 N/A physical interaction ComPPI
MECP2 TOP3A 25348397 N/A physical interaction ComPPI
MECP2 SPOUT1 25348397 N/A physical interaction ComPPI
MECP2 NOP16 25348397 N/A physical interaction ComPPI
MECP2 SDAD1 25348397 N/A physical interaction ComPPI
MECP2 RPL17 25348397 N/A physical interaction ComPPI
MECP2 PYHIN1 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
H3C1 MECP2 25348397 N/A physical interaction ComPPI
TBL1XR1 MECP2 23770565 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TAF1D MECP2 25348397 N/A physical interaction ComPPI
ZNF593 MECP2 25348397 N/A physical interaction ComPPI
RRP7A MECP2 25348397 N/A physical interaction ComPPI
MECP2 PRMT6 21497756 27898060 N/A N/A OmniPath
ATRX MECP2 17296936 20159591 27898060 N/A N/A OmniPath

Visualization










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