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GENE：MEF2D

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MEF2D
FullNmae myocyte enhancer factor 2D
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6997
EnsembleID ENSG00000116604
Uniprot Q14814

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MEF2D necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MEF2D autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MEF2D GO:0000785,GO:0000977,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0001228,GO:0001649,GO:0001958,GO:0002062,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006915,GO:0007399,GO:0007512,GO:0007517,GO:0030154,GO:0035914,GO:0042803,GO:0042826,GO:0043231,GO:0045944,GO:0045944,GO:0046982,GO:0061629,GO:0140297,GO:1904707,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MEF2D hsa:4209 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
MEF2D hsa:4209 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
MEF2D hsa:4209 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EGR1 MEF2D 20690147 23180781 physical association anti tag coimmunoprecipitation InnateDB
YWHAQ MEF2D 11433030 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR MEF2D 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR2 MEF2D 20034404 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 MEF2D 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 MEF2D 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MEF2D 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C MEF2D 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 MEF2D 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 MEF2D 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MEF2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MEF2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MEF2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MEF2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MEF2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MEF2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MEF2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MEF2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MEF2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MEF2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR MEF2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MEF2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HDAC7 MEF2D 11585834 trascriptional regulation,stimulation inferred by curator TFlink
HDAC9 MEF2D 11585834 trascriptional regulation,stimulation inferred by curator TFlink
JUN MEF2D 12054430 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002075FA MEF2D 19666108 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000042E1F MEF2D 19666108 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000042E1F MEF2D 19666108 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00002075FA MEF2D 19666108 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000157026 MEF2D 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000003ABC4 MEF2D 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000070B1D MEF2D 19536157 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00003CF1AD MEF2D 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003380CC MEF2D 24390737 25416803 27109478 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000055128B MEF2D 19536157 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA MEF2D 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002E728C MEF2D 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002B0B46 MEF2D 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000076E54 MEF2D 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005FDE70 MEF2D 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003CC709 MEF2D 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005ECFE5 MEF2D 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000184017 MEF2D 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003BD367 MEF2D 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000453664 MEF2D 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000E7139 MEF2D 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000032D69B MEF2D 22291592 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS0000237AF9 MEF2D 22291592 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 MEF2D 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 MEF2D 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000077DDE MEF2D 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000005481D MEF2D 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000075E2C3 MEF2D 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002F0130 MEF2D 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 MEF2D 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 MEF2D 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000035CC3E MEF2D 25416803 26356851 mrna cleavage,inhibition western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000006FDD4 MEF2D 25416803 26762410 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000324096 MEF2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000031E12 MEF2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000A07C1 MEF2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000000B1C9 MEF2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000029979D MEF2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000237CBD MEF2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000044FD7 MEF2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000192A75 MEF2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000042935A MEF2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000017CCCB MEF2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000032EF64 MEF2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003FBC84 MEF2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002578DA MEF2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000006372A MEF2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003D5391 MEF2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075A608 MEF2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000122ED0 MEF2D 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK4 MEF2D 22135298 phosphorylation N/A PhosphoSite
CDK5 MEF2D 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CDK6 MEF2D 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
SP1 MEF2D 12213324 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
JUN MEF2D 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
EP300 MEF2D 11096067 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
COPS5 MEF2D 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HDAC3 MEF2D 25348397 N/A physical interaction ComPPI
MAPK14 MEF2D 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HDAC4 MEF2D 10523670 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
KAT2B MEF2D 25348397 N/A physical interaction ComPPI
PRKACA MEF2D 25348397 N/A physical interaction ComPPI
HIRA MEF2D 25348397 N/A physical interaction ComPPI
KMT2D MEF2D 25348397 N/A physical interaction ComPPI
CASP7 MEF2D 11904443 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ASH2L MEF2D 25348397 N/A physical interaction ComPPI
PRMT5 MEF2D 25348397 N/A physical interaction ComPPI
NFATC2 MEF2D 10944115 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PKM MEF2D 25348397 N/A protein kinase assay ComPPI
XPO1 MEF2D 25348397 N/A physical interaction ComPPI
YWHAQ MEF2D 11433030 14525934 24234451 25348397 association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
RBBP5 MEF2D 25348397 N/A physical interaction ComPPI
MAPK7 MEF2D 10849446 14525934 25348397 9753748 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HTT MEF2D 17500595 24234451 25348397 physical association two hybrid ComPPI,IntAct
SKP2 MEF2D 25348397 N/A physical interaction ComPPI
MEF2C MEF2D 14525934 25348397 9858528 N/A experimental interaction detection,in vitro ComPPI,HPRD
MEF2D MEF2A 14525934 24234451 25348397 25609649 8798771 9858528 association experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
MEF2D HDAC5 10737771 12896970 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MEF2D CABIN1 14525934 15902271 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MEF2D SNCA 25348397 N/A physical interaction ComPPI
MEF2D CARM1 25348397 N/A physical interaction ComPPI
MEF2D SENP3 25348397 N/A physical interaction ComPPI
MEF2D MEN1 25348397 N/A physical interaction ComPPI
MEF2D HDAC1 25348397 N/A physical interaction ComPPI
MEF2D ASCL1 25348397 N/A physical interaction ComPPI
MEF2D APP 25348397 N/A physical interaction ComPPI
MEF2D SHMT2 25348397 N/A physical interaction ComPPI
MEF2D MOV10 25348397 N/A physical interaction ComPPI
MEF2D NXF1 25348397 N/A physical interaction ComPPI
MEF2D FUS 25348397 N/A physical interaction ComPPI
MEF2D DNMT3L 25348397 N/A physical interaction ComPPI
MEF2D MEF2B 25348397 N/A physical interaction ComPPI
MEF2D MEF2D 14525934 9858528 N/A experimental interaction detection HPRD
CDK5 MEF2D 16356933 27898060 N/A N/A OmniPath
CASP7 MEF2D 11904443 27898060 N/A N/A OmniPath
MAPK7 MEF2D 10849446 16964243 18669648 18691976 18767875 20068231 27898060 9753748 stimulant N/A OmniPath
MAPK14 MEF2D 18026121 20936779 21902831 26186194 27898060 stimulant N/A OmniPath
CDK1 MEF2D 10849446 27898060 N/A N/A OmniPath
HDAC4 MEF2D 10523670 10737771 16166628 16356933 17158926 27898060 inhibition N/A OmniPath
CDK4 MEF2D 21902831 25733682 27898060 inhibition N/A OmniPath
EP300 MEF2D 10825153 10933397 11096067 11796223 27898060 stimulant N/A OmniPath
YWHAQ MEF2D 11433030 27898060 stimulant N/A OmniPath
NFATC2 MEF2D 10944115 11796223 27898060 stimulant N/A OmniPath
HDAC5 MEF2D 10737771 11062529 12896970 27898060 inhibition N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008B99A6 MEF2D 27087310 direct interaction,inhibition N/A NPInter

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