GENE：PER2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PER2 |
| FullNmae | period circadian regulator 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:8846 |
| EnsembleID | ENSG00000132326 |
| Uniprot | O15055 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PER2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PER2 | GO:0000122,GO:0000122,GO:0000976,GO:0000976,GO:0001222,GO:0002931,GO:0003713,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005978,GO:0006094,GO:0006338,GO:0006631,GO:0007623,GO:0019229,GO:0019249,GO:0031397,GO:0032922,GO:0032922,GO:0042752,GO:0042754,GO:0043153,GO:0045892,GO:0045893,GO:0048471,GO:0050767,GO:0050796,GO:0050872,GO:0051726,GO:0051946,GO:0070345,GO:0097167,GO:0120162,GO:2000678 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PER2 | hsa:8864 | path:hsa04710 | Circadian rhythm - Homo sapiens (human) |
| PER2 | hsa:8864 | path:hsa04713 | Circadian entrainment - Homo sapiens (human) |
| PER2 | hsa:8864 | path:hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| PER2 | hsa:8864 | path:hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PER2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | PER2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | PER2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PER2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PER2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | PER2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PER2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PER2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PER2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PER2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | PER2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ARNTL | PER2 | 17660446 22750052 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CLOCK | PER2 | 17660446 22750052 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NPAS2 | PER2 | 17660446 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000048BA36 | PER2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000330617 | PER2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075BDA4 | PER2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272039 | PER2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000009262D | PER2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000355E82 | PER2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006372A | PER2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C0099 | PER2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000043C1C3 | PER2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003FBC84 | PER2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041FA2C | PER2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CC4BD | PER2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000486E0B | PER2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000047A67D | PER2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000302909 | PER2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075B538 | PER2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005E6F45 | PER2 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000054DF42 | PER2 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001E96DA | PER2 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040828B | PER2 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000021D7C8 | PER2 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CF3F0 | PER2 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C85B2 | PER2 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FC5B0 | PER2 | 19536157 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B989F | PER2 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A7F58 | PER2 | 19536157 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000005A8ED | PER2 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001DE669 | PER2 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000005CF5F | PER2 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002152A8 | PER2 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000236310 | PER2 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065D58 | PER2 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000018C928 | PER2 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CSNK1E | PER2 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| CSNK1D | PER2 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| PER2 | FBXW11 | 25361965 | interaction type | N/A | PTMCode2 |
| FBXW11 | PER2 | 25361965 | interaction type | N/A | PTMCode2 |
| PER2 | CLOCK | 25361965 | interaction type | N/A | PTMCode2 |
| CLOCK | PER2 | 25361965 | interaction type | N/A | PTMCode2 |
| PER2 | PER1 | 25361965 | interaction type | N/A | PTMCode2 |
| PER1 | PER2 | 25361965 | interaction type | N/A | PTMCode2 |
| PER2 | CSNK1D | 25361965 | interaction type | N/A | PTMCode2 |
| PER2 | NPAS2 | 25361965 | interaction type | N/A | PTMCode2 |
| NPAS2 | PER2 | 25361965 | interaction type | N/A | PTMCode2 |
| PER2 | CSNK1E | 25361965 | interaction type | N/A | PTMCode2 |
| PER2 | PER3 | 25361965 | interaction type | N/A | PTMCode2 |
| PER3 | PER2 | 25361965 | interaction type | N/A | PTMCode2 |
| PER2 | BTRC | 25361965 | interaction type | N/A | PTMCode2 |
| BTRC | PER2 | 25361965 | interaction type | N/A | PTMCode2 |
| PER2 | ARNTL | 25361965 | interaction type | N/A | PTMCode2 |
| ARNTL | PER2 | 25361965 | interaction type | N/A | PTMCode2 |
| PER2 | CRY2 | 25361965 | interaction type | N/A | PTMCode2 |
| CRY2 | PER2 | 25361965 | interaction type | N/A | PTMCode2 |
| SIRT1 | PER2 | 25361965 | interaction type | N/A | PTMCode2 |
| PER2 | SIRT1 | 25361965 | interaction type | N/A | PTMCode2 |
| CRY1 | PER2 | 25361965 | interaction type | N/A | PTMCode2 |
| PER2 | CRY1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LMO4 | PER2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| UBL4A | PER2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CSNK1D | PER2 | 14525934 15800623 21179498 24234451 25348397 | phosphorylation reaction,physical association | two hybrid,experimental interaction detection,phosphorylation reaction,physical interaction,two hybrid array,protein kinase assay,in vitro,two hybrid prey pooling approach | ComPPI,HPRD,IntAct |
| BTRC | PER2 | 25348397 | N/A | physical interaction | ComPPI |
| CSNK1E | PER2 | 11232563 14525934 16790549 17218255 24234451 25348397 9349507 | phosphorylation reaction,association,physical association | anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,protein kinase assay,in vitro,in vivo,two hybrid prey pooling approach | ComPPI,HPRD,IntAct |
| MDM2 | PER2 | 25348397 | N/A | physical interaction | ComPPI |
| TPT1 | PER2 | 25348397 | N/A | physical interaction | ComPPI |
| PER3 | PER2 | 10837028 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| PER1 | PER2 | 10848614 11165242 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| CRY2 | PER2 | 10428031 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| ELAVL1 | PER2 | 25348397 | N/A | physical interaction | ComPPI |
| ELOA | PER2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| PER2 | TIMELESS | 14525934 25348397 9856465 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PER2 | CRY1 | 10428031 10531061 11533252 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| PER2 | TP53 | 25348397 | N/A | physical interaction | ComPPI |
| PER2 | CSNK2B | 25348397 | N/A | physical interaction | ComPPI |
| PER2 | DELEC1 | 25348397 | N/A | physical interaction | ComPPI |
| PER2 | RORC | 25348397 | N/A | physical interaction | ComPPI |
| PER2 | CLOCK | 25348397 | N/A | physical interaction | ComPPI |
| PER2 | BHLHE41 | 25348397 | N/A | physical interaction | ComPPI |
| PER2 | PML | 25348397 | N/A | physical interaction | ComPPI |
| PER2 | FBXW11 | 25348397 | N/A | physical interaction | ComPPI |
| PER2 | TNFRSF14 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| PER2 | MLH1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| PER2 | LENG8 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| PER2 | ARNTL | 14701732 16717091 18662546 21113167 21680841 22274616 27898060 | inhibition | N/A | OmniPath |
| CSNK1E | PER2 | 11232563 11475410 15767683 17218255 21324900 21680841 24857656 27898060 9349507 | stimulant | N/A | OmniPath |
| NPAS2 | PER2 | 19106159 27898060 | stimulant | N/A | OmniPath |
| SIRT1 | PER2 | 18662546 27898060 | inhibition | N/A | OmniPath |
| CSNK1D | PER2 | 15800623 17218251 17218255 19414593 21324900 27898060 | inhibition,stimulant | N/A | OmniPath |
| PER2 | POU2F1 | 23836662 27898060 | inhibition | N/A | OmniPath |