Gene Information gene info

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GENE：SIX1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SIX1
FullNmae SIX homeobox 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10887
EnsembleID ENSG00000126778
Uniprot Q15475

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SIX1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SIX1 GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001223,GO:0001228,GO:0001228,GO:0001657,GO:0001658,GO:0001759,GO:0001822,GO:0003151,GO:0003677,GO:0003682,GO:0003700,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005667,GO:0005667,GO:0005730,GO:0005737,GO:0006355,GO:0006357,GO:0006915,GO:0007219,GO:0007389,GO:0007519,GO:0007605,GO:0008582,GO:0010467,GO:0014033,GO:0014842,GO:0014857,GO:0021610,GO:0030855,GO:0030878,GO:0030910,GO:0032880,GO:0034504,GO:0035909,GO:0042472,GO:0042474,GO:0043524,GO:0043565,GO:0045664,GO:0045893,GO:0045893,GO:0045944,GO:0045944,GO:0048538,GO:0048665,GO:0048699,GO:0048701,GO:0048704,GO:0048741,GO:0048839,GO:0050678,GO:0051450,GO:0051451,GO:0060037,GO:0061055,GO:0061197,GO:0061551,GO:0071599,GO:0072075,GO:0072095,GO:0072107,GO:0072172,GO:0072193,GO:0072198,GO:0072513,GO:0086100,GO:0090103,GO:0090190,GO:0090336,GO:1905243,GO:1990837,GO:2000288,GO:2000729,GO:2001014

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SIX1 hsa:6495 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SIX1 CDH1 17130831 23180781 physical association gst pull down InnateDB
SIX1 MDFI 16189514 23180781 physical association pull down InnateDB
TLE5 SIX1 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR SIX1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 SIX1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SIX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SIX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SIX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SIX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SIX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SIX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 SIX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 SIX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 SIX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002367FA SIX1 20603620 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00002367FA SIX1 20603620 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000AA464 SIX1 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 SIX1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000005481D SIX1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002152A8 SIX1 24593661 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS000029D9F1 SIX1 25157435 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00000B59A2 SIX1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00004DA9DB SIX1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000292B1 SIX1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B SIX1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC SIX1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFBE3 SIX1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD SIX1 20371350 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000002569A SIX1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001270D3 SIX1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000CBE63 SIX1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001A4ABF SIX1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003AFAD1 SIX1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075ABF4 SIX1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF SIX1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 SIX1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000000EF0B SIX1 19536157 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00003E226A SIX1 19536157 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001F0C23 SIX1 19536157 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001A122A SIX1 19536157 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000005D4F5 SIX1 19536157 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000008B558 SIX1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002F3336 SIX1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032BDF4 SIX1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F SIX1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075E2C3 SIX1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000CC005 SIX1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 SIX1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEE35 SIX1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F SIX1 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SIX1 EYA2 25361965 interaction type N/A PTMCode2
EYA2 SIX1 25361965 interaction type N/A PTMCode2
SIX1 EYA1 25361965 interaction type N/A PTMCode2
EYA1 SIX1 25361965 interaction type N/A PTMCode2
SIX1 EYA4 25361965 interaction type N/A PTMCode2
EYA4 SIX1 25361965 interaction type N/A PTMCode2
SIX1 EYA3 25361965 interaction type N/A PTMCode2
EYA3 SIX1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
H2AP SIX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DACH1 SIX1 25348397 N/A in vitro ComPPI
SIX1 EYA1 11734542 12874121 14525934 15226428 15492887 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
SIX1 EYA3 12215533 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SIX1 MDFI 14525934 16189514 24234451 25348397 physical association two hybrid,pull down,physical interaction,two hybrid pooling approach,two hybrid ComPPI,HPRD,IntAct
SIX1 CCDC85B 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SIX1 EYA2 10906137 19497856 21516116 23435380 24234451 25348397 27898060 physical association two hybrid,molecular sieving,x-ray crystallography,physical interaction ComPPI,IntAct,OmniPath
SIX1 TLE1 12441302 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
SIX1 TLE5 12441302 14525934 24234451 25348397 25416956 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
SIX1 SKI 25348397 N/A physical interaction ComPPI
SIX1 FZR1 25348397 N/A physical interaction ComPPI
SIX1 VTN 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SIX1 EYA4 14525934 15492887 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
SIX1 MYH3 25348397 N/A physical interaction ComPPI
SIX1 MYH7 25348397 N/A physical interaction ComPPI
SIX1 MYH4 25348397 N/A physical interaction ComPPI
SIX1 FOXE1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
SIX1 FOXL2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
SIX1 ERCC6L 25348397 N/A physical interaction ComPPI
SIX1 P4HA3 25348397 N/A physical interaction ComPPI
SIX1 PLEKHG4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SIX1 POU6F2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SIX1 SIX1 11734542 14525934 N/A experimental interaction detection HPRD
CDH1 SIX1 17130831 27898060 N/A N/A OmniPath
SIX1 BMP4 12874121 27898060 stimulant N/A OmniPath
FOXI1 SIX1 17035528 27898060 stimulant N/A OmniPath
SIX1 EYA1 11734542 12874121 15226428 15492887 17035528 26186194 27898060 inhibition N/A OmniPath
SIX1 GATA3 12874121 27898060 stimulant N/A OmniPath
SIX1 OTX2 14695375 27898060 stimulant N/A OmniPath
SIX1 DACH1 14628042 14695375 17035528 27898060 inhibition,stimulant N/A OmniPath
SIX1 FGF10 12874121 27898060 stimulant N/A OmniPath
SIX1 DLX5 14695375 27898060 inhibition N/A OmniPath
SIX1 FGF3 12874121 27898060 stimulant N/A OmniPath
SIX1 LFNG 14695375 27898060 stimulant N/A OmniPath
SIX1 PAX2 17035528 27898060 stimulant N/A OmniPath
SIX1 DACH2 14695375 27898060 inhibition N/A OmniPath
SIX1 OTX1 14695375 27898060 stimulant N/A OmniPath

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