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GENE：TOB1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TOB1
FullNmae transducer of ERBB2, 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11979
EnsembleID ENSG00000141232
Uniprot P50616

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TOB1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TOB1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TOB1 GO:0003714,GO:0005515,GO:0005634,GO:0005737,GO:0008285,GO:0010468,GO:0017148,GO:0030014,GO:0030514,GO:0030971,GO:0045668,GO:0045892,GO:0046332,GO:0060212,GO:0060213,GO:0060390,GO:1900153

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TOB1 hsa:10140 path:hsa03018 RNA degradation - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APP TOB1 21832049 23180781 physical association protein array InnateDB
TOB1 ELAVL1 19322201 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
TOB1 ERBB2 20005715 interaction type N/A PSP
TOB1 MAPK1 12151396 20005715 21071413 interaction type N/A PSP,SignaLink
TOB1 MAPK9 12151396 20005715 21071413 interaction type N/A PSP,SignaLink
TOB1 RPS6KA1 11260258 20005715 21071413 interaction type N/A PSP,SignaLink
TOB1 ERBB2 18988627 20005715 20005715 8632892 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ESR1 TOB1 18414489 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation array,chromatin immunoprecipitation assay TFlink
ETS1 TOB1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 TOB1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TOB1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 TOB1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 TOB1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 TOB1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 TOB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TOB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TOB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TOB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 TOB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TOB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TOB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TOB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR TOB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 TOB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000039D790 TOB1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA TOB1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C85B2 TOB1 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 TOB1 20371350 21572407 22012620 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F TOB1 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 TOB1 20371350 21572407 22012620 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000237AF9 TOB1 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000040EC3B TOB1 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004CCA62 TOB1 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000003ABC4 TOB1 20371350 21572407 22012620 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00004AF715 TOB1 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000045B99E TOB1 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000254A6 TOB1 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK3 TOB1 22135298 phosphorylation N/A PhosphoSite
MAPK1 TOB1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK9 TOB1 22135298 phosphorylation N/A PhosphoSite
TOB1 MAPK1 25361965 interaction type N/A PTMCode2
TOB1 ERBB2 25361965 interaction type N/A PTMCode2
ERBB2 TOB1 25361965 interaction type N/A PTMCode2
TOB1 SMAD6 25361965 interaction type N/A PTMCode2
SMAD6 TOB1 25361965 interaction type N/A PTMCode2
TOB1 PABPC1 25361965 interaction type N/A PTMCode2
PABPC1 TOB1 25361965 interaction type N/A PTMCode2
TOB1 CNOT1 25361965 interaction type N/A PTMCode2
CNOT1 TOB1 25361965 interaction type N/A PTMCode2
TOB1 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 TOB1 25361965 interaction type N/A PTMCode2
TOB1 CNOT7 25361965 interaction type N/A PTMCode2
CNOT7 TOB1 25361965 interaction type N/A PTMCode2
TOB1 SMAD9 25361965 interaction type N/A PTMCode2
SMAD9 TOB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HNRNPK TOB1 18377426 24234451 25348397 association tandem affinity purification ComPPI,IntAct
MAPK9 TOB1 25348397 N/A physical interaction ComPPI
SMAD4 TOB1 11163184 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HNRNPH2 TOB1 18377426 24234451 25348397 association tandem affinity purification ComPPI,IntAct
ERBB2 TOB1 14525934 25348397 8632892 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TOB1 MAPK1 12050114 12151396 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
TOB1 SMAD2 11163184 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TOB1 SMAD1 11163184 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TOB1 SMAD3 11163184 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TOB1 SMAD5 11163184 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TOB1 SMAD9 25348397 N/A physical interaction,in vivo ComPPI
TOB1 CNOT7 10602502 11429045 18056425 18377426 19276069 20595394 21336257 24234451 25348397 26186194 27898060 association anti tag coimmunoprecipitation,isothermal titration calorimetry,molecular sieving,pull down,x-ray crystallography,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,IntAct,OmniPath
TOB1 MARCKS 11327693 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
TOB1 SMAD6 12782279 14525934 25348397 27898060 N/A two hybrid,two hybrid ComPPI,HPRD,OmniPath
TOB1 SETDB1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TOB1 SCMH1 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
TOB1 PABPC1 20595394 24234451 25348397 N/A isothermal titration calorimetry,nuclear magnetic resonance,physical interaction ComPPI,IntAct
TOB1 RPS6KA1 25348397 N/A physical interaction ComPPI
TOB1 SKP2 25348397 N/A physical interaction ComPPI
TOB1 CTNNB1 25348397 N/A physical interaction ComPPI
TOB1 CORO7 25348397 N/A physical interaction ComPPI
TOB1 ELAVL1 25348397 N/A physical interaction ComPPI
TOB1 UBR5 25348397 N/A physical interaction ComPPI
TOB1 PAN2 25348397 N/A physical interaction ComPPI
TOB1 CDC7 25348397 N/A physical interaction ComPPI
TOB1 DTL 25348397 N/A physical interaction ComPPI
TOB1 APP 25348397 N/A physical interaction ComPPI
TOB1 NXF1 25348397 N/A physical interaction ComPPI
TOB1 CNOT1 18377426 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
TOB1 CNOT6 25348397 N/A physical interaction ComPPI
TOB1 CNOT6L 18377426 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
TOB1 CNOT2 18377426 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TOB1 TNKS1BP1 18377426 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TOB1 CNOT3 18377426 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
TOB1 CNOT9 18377426 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TOB1 CNOT11 25348397 N/A physical interaction ComPPI
TOB1 CNOT8 25348397 N/A physical interaction ComPPI
TOB1 CNOT10 18377426 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TOB1 RAVER1 18377426 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TOB1 FHL2 25348397 N/A physical interaction ComPPI
TOB1 ATE1 25348397 N/A physical interaction ComPPI
TOB1 FBXL13 25348397 N/A physical interaction ComPPI
TOB1 KHDRBS1 18377426 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TOB1 TARDBP 18377426 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TOB1 TIA1 18377426 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TOB1 HNRNPA2B1 18377426 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TOB1 HNRNPH1 18377426 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TOB1 HNRNPH3 18377426 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TOB1 DDX3X 18377426 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TOB1 DDX5 18377426 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TOB1 CPEB3 21336257 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down ComPPI,IntAct
TOB1 CPEB4 21336257 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
CHAF1A TOB1 25348397 N/A physical interaction ComPPI
HNRNPF TOB1 18377426 24234451 25348397 association tandem affinity purification ComPPI,IntAct
OBI1 TOB1 25348397 N/A physical interaction ComPPI
MAPK9 TOB1 12050114 12151396 27898060 inhibition N/A OmniPath
MAPK3 TOB1 12050114 12151396 22252318 27898060 inhibition N/A OmniPath
MAPK1 TOB1 12050114 12151396 20068231 27898060 inhibition N/A OmniPath

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