GENE：ZFP36
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ZFP36 |
| FullNmae | ZFP36 ring finger protein |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:12862 |
| EnsembleID | ENSG00000128016 |
| Uniprot | P26651 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ZFP36 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ZFP36 | GO:0000122,GO:0000165,GO:0000165,GO:0000288,GO:0000289,GO:0000932,GO:0003677,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005829,GO:0006402,GO:0009611,GO:0009611,GO:0010494,GO:0010837,GO:0019899,GO:0019901,GO:0019957,GO:0030099,GO:0031072,GO:0031086,GO:0032680,GO:0032703,GO:0032897,GO:0035278,GO:0035925,GO:0035925,GO:0035925,GO:0038066,GO:0042594,GO:0043488,GO:0043488,GO:0044344,GO:0044877,GO:0045600,GO:0045616,GO:0045647,GO:0046872,GO:0050728,GO:0051028,GO:0060213,GO:0060218,GO:0061158,GO:0061158,GO:0070063,GO:0070935,GO:0071222,GO:0071222,GO:0071356,GO:0071364,GO:0071385,GO:0071889,GO:0097011,GO:1900153,GO:1900153,GO:1901835,GO:1902037,GO:1902172,GO:1904246,GO:1904582,GO:1990904,GO:2000637 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ZFP36 | hsa:7538 | path:hsa05166 | Human T-cell leukemia virus 1 infection - Homo sapiens (human) |
| ZFP36 | hsa:7538 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ZFP36 | B4GALT1 | 16024783 23180781 | physical association | affinity chromatography technology | InnateDB |
| KHSRP | ZFP36 | 16126846 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| EGR1 | ZFP36 | 19374776 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| ZFP36 | TNF | 23180781 24253039 | physical association | electrophoretic mobility shift assay,saturation binding | InnateDB |
| ZFP36 | YY1 | 23180781 25644713 | physical association | anti tag coimmunoprecipitation | InnateDB |
| ZFP36 | HIF1A | 23180781 25644713 | physical association | anti tag coimmunoprecipitation | InnateDB |
| MAP3K1 | ZFP36 | 21921033 | phosphorylation reaction,stimulation | N/A | SignaLink |
| TRAF2 | ZFP36 | 21921033 | ubiquitination reaction,stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ZFP36 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | ZFP36 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | ZFP36 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| MYC | ZFP36 | 12695333 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | ZFP36 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| NR1I2 | ZFP36 | 19129222 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| E2F4 | ZFP36 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ZFP36 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | ZFP36 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | ZFP36 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | ZFP36 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ELK1 | ZFP36 | 22433566 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD3 | ZFP36 | 12754205 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD4 | ZFP36 | 12754205 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT3 | ZFP36 | 21606497 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000134ADC | ZFP36 | 21611196 | rna interference,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr | miRSponge |
| URS0000076995 | ZFP36 | 23401122 24103357 25416803 26356262 | mrna cleavage,inhibition | experimental interaction detection,western blot,miRNA interference luciferase reporter assay | TarBase |
| URS0000134ADC | ZFP36 | 21611196 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr | TarBase |
| URS0000381CEC | ZFP36 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002F74F1 | ZFP36 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000338542 | ZFP36 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005485E8 | ZFP36 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000330617 | ZFP36 | 23313552 23446348 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00001B341F | ZFP36 | 23313552 23446348 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000475586 | ZFP36 | 23313552 23446348 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00001D69F6 | ZFP36 | 23313552 23446348 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002075FA | ZFP36 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075ABF4 | ZFP36 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000009EA8F | ZFP36 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002394F5 | ZFP36 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00004E02F2 | ZFP36 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000BD6DC | ZFP36 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000004BACE | ZFP36 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000ECE9C | ZFP36 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000001A7A | ZFP36 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D15B | ZFP36 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E728C | ZFP36 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAPK1 | ZFP36 | 25361965 | interaction type | N/A | PTMCode2 |
| ZFP36 | MAPK1 | 25361965 | interaction type | N/A | PTMCode2 |
| ZFP36 | XRN1 | 25361965 | interaction type | N/A | PTMCode2 |
| XRN1 | ZFP36 | 25361965 | interaction type | N/A | PTMCode2 |
| ZFP36 | EDC3 | 25361965 | interaction type | N/A | PTMCode2 |
| EDC3 | ZFP36 | 25361965 | interaction type | N/A | PTMCode2 |
| ZFP36 | EDC4 | 25361965 | interaction type | N/A | PTMCode2 |
| EDC4 | ZFP36 | 25361965 | interaction type | N/A | PTMCode2 |
| ZFP36 | DCP2 | 25361965 | interaction type | N/A | PTMCode2 |
| DCP2 | ZFP36 | 25361965 | interaction type | N/A | PTMCode2 |
| ZFP36 | EXOSC8 | 25361965 | interaction type | N/A | PTMCode2 |
| EXOSC8 | ZFP36 | 25361965 | interaction type | N/A | PTMCode2 |
| ZFP36 | EXOSC6 | 25361965 | interaction type | N/A | PTMCode2 |
| EXOSC6 | ZFP36 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SPRY2 | ZFP36 | 25348397 | N/A | physical interaction | ComPPI |
| SH3KBP1 | ZFP36 | 25348397 | N/A | physical interaction | ComPPI |
| TFRC | ZFP36 | 25348397 | N/A | physical interaction | ComPPI |
| EDC3 | ZFP36 | 16364915 24234451 25348397 | association,physical association | anti tag coimmunoprecipitation,physical interaction,in vitro,in vivo | ComPPI,IntAct |
| CDK6 | ZFP36 | 25348397 | N/A | physical interaction | ComPPI |
| YWHAG | ZFP36 | 25348397 | N/A | in vitro | ComPPI |
| CCDC85B | ZFP36 | 16189514 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach | ComPPI,IntAct |
| DDX17 | ZFP36 | 18334637 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| EXOSC8 | ZFP36 | 15231747 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| DCP1A | ZFP36 | 16364915 24234451 25348397 | association,physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MAPK1 | ZFP36 | 25348397 | N/A | in vitro,in vivo | ComPPI |
| RGS16 | ZFP36 | 25348397 | N/A | physical interaction | ComPPI |
| HDAC3 | ZFP36 | 25348397 | N/A | physical interaction | ComPPI |
| YWHAB | ZFP36 | 25348397 | N/A | physical interaction,in vivo | ComPPI |
| MAP3K4 | ZFP36 | 25348397 | N/A | physical interaction | ComPPI |
| DCP1B | ZFP36 | 25348397 | N/A | physical interaction | ComPPI |
| PPP2CB | ZFP36 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | SFN | 25348397 | N/A | in vivo | ComPPI |
| ZFP36 | UPF2 | 15231747 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| ZFP36 | MAPKAPK2 | 25348397 | N/A | physical interaction,in vitro,in vivo | ComPPI |
| ZFP36 | EXOSC6 | 25348397 | N/A | two hybrid,physical interaction | ComPPI |
| ZFP36 | YWHAH | 25348397 | N/A | two hybrid,physical interaction,in vitro,in vivo | ComPPI |
| ZFP36 | NUP214 | 14766228 25348397 27898060 | N/A | two hybrid,physical interaction,in vivo | ComPPI,OmniPath |
| ZFP36 | XRN1 | 25348397 | N/A | two hybrid,physical interaction | ComPPI |
| ZFP36 | NFKB1 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | HDAC1 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | HDAC7 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | NCL | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | PABPC1 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | HSPA4 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | LIN28A | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | APP | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | DCP2 | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
| ZFP36 | EDC4 | 16364915 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ZFP36 | TNF | 15014438 21784977 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| ZFP36 | TRAF2 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | PPP2CA | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | PRR5L | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | DNAJB1 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | DHX36 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | CCL3 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | DUSP2 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | ZEB2 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | HNRNPA2B1 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | COMMD6 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | MED30 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | KLHL2 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | ATP6V1E1 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | METTL9 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | STK40 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | TANK | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | ZDHHC17 | 24234451 24705354 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| ZFP36 | XPO1 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | CNOT6 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | CNOT6L | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | CNOT8 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | CNOT7 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | PAN2 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | CNOT1 | 23644599 25348397 27898060 | N/A | isothermal titration calorimetry,pull down,x-ray crystallography,physical interaction | ComPPI,OmniPath |
| ZFP36 | SF1 | 24234451 25348397 26420826 | physical association | two hybrid fragment pooling approach | ComPPI,IntAct |
| ZFP36 | DDX39B | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| HMGB1 | ZFP36 | 25348397 | N/A | in vitro | ComPPI |
| YWHAQ | ZFP36 | 25348397 | N/A | physical interaction | ComPPI |
| HOXC9 | ZFP36 | 25348397 | N/A | physical interaction | ComPPI |
| ZFP36 | KHSRP | 16126846 27898060 | N/A | N/A | OmniPath |
| MAPKAPK2 | ZFP36 | 14688255 15014438 18669648 20599781 27898060 | inhibition,stimulant | N/A | OmniPath |
| MAPK14 | ZFP36 | 20599781 27898060 | stimulant | N/A | OmniPath |
| MAPK1 | ZFP36 | 27898060 7768935 95286626 | stimulant | N/A | OmniPath |
| PAK2 | ZFP36 | 16262601 27898060 | N/A | N/A | OmniPath |