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GENE：NEK6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NEK6
FullNmae NIMA related kinase 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7749
EnsembleID ENSG00000119408
Uniprot Q9HC98

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NEK6 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NEK6 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NEK6 GO:0000287,GO:0000922,GO:0001222,GO:0004674,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005829,GO:0005829,GO:0005874,GO:0006468,GO:0006915,GO:0007052,GO:0007059,GO:0007059,GO:0007077,GO:0007346,GO:0016607,GO:0018105,GO:0018105,GO:0019894,GO:0019901,GO:0030071,GO:0030071,GO:0031625,GO:0032991,GO:0034451,GO:0043123,GO:0046777,GO:0051225,GO:0051301,GO:0106310,GO:0140297,GO:2000772

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TLE5 NEK6 23180781 25416956 physical association two hybrid InnateDB
XIAP NEK6 23180781 25416956 physical association two hybrid InnateDB
TRIM23 NEK6 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR NEK6 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 NEK6 20034404 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 NEK6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 NEK6 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 NEK6 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A NEK6 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 NEK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NEK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NEK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NEK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NEK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NEK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NEK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF NEK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 NEK6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EEF5F NEK6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001CC864 NEK6 24942805 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
NEK6 RPS6KB1 22135298 phosphorylation N/A PhosphoSite
NEK6 SGK1 22135298 phosphorylation N/A PhosphoSite
NEK6 DDR1 22135298 phosphorylation N/A PhosphoSite
NEK6 ACD 22135298 phosphorylation N/A PhosphoSite
NEK6 RBL2 22135298 phosphorylation N/A PhosphoSite
NEK6 CDK7 22135298 phosphorylation N/A PhosphoSite
NEK6 STAT3 22135298 phosphorylation N/A PhosphoSite
NEK6 GRIN1 22135298 phosphorylation N/A PhosphoSite
NEK6 HSPA1A 22135298 phosphorylation N/A PhosphoSite
NEK9 NEK6 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PIN1 NEK6 25361965 interaction type N/A PTMCode2
NEK6 PIN1 25361965 interaction type N/A PTMCode2
NEK6 NEK9 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 NEK6 14525934 16476580 24234451 25348397 27898060 colocalization,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,fluorescence microscopy,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
DYNLL1 NEK6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NECAB2 NEK6 14525934 16189514 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CDC42 NEK6 25348397 N/A physical interaction ComPPI
RPS7 NEK6 25348397 N/A physical interaction ComPPI
LZTS2 NEK6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ATF4 NEK6 25348397 N/A physical interaction ComPPI
XIAP NEK6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SMAD4 NEK6 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
KRT31 NEK6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CCDC85B NEK6 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
KRT40 NEK6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
HSD17B14 NEK6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SMURF2 NEK6 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NFATC1 NEK6 25348397 N/A physical interaction ComPPI
PRAM1 NEK6 25348397 N/A physical interaction ComPPI
TRIP4 NEK6 25348397 N/A physical interaction ComPPI
RBBP6 NEK6 25348397 N/A physical interaction ComPPI
XPO5 NEK6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HNRNPL NEK6 25348397 N/A physical interaction ComPPI
PKM NEK6 25348397 N/A protein kinase assay ComPPI
ARRB1 NEK6 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RPS6KB1 NEK6 11516946 12023960 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NSF NEK6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TRIM23 NEK6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SMC1A NEK6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NCAPG2 NEK6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
WEE1 NEK6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TLE5 NEK6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CDK7 NEK6 12023960 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
IKZF3 NEK6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SMC3 NEK6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TNK2 NEK6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PSMD2 NEK6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
LAMP2 NEK6 25348397 N/A physical interaction ComPPI
LRPPRC NEK6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC37 NEK6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PAK6 NEK6 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ANKRA2 NEK6 25348397 N/A physical interaction ComPPI
IKZF1 NEK6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SGK1 NEK6 10191262 12023960 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TNPO3 NEK6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
COPG2 NEK6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CIR1 NEK6 25348397 N/A physical interaction ComPPI
NEK9 NEK6 12101123 12840024 14525934 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
TRIM27 NEK6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
HACD3 NEK6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK6 EML3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK6 USP9X 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK6 CCAR2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK6 IPO4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK6 NEK7 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK6 MCM7 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK6 EML2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK6 SLC1A5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK6 NUP93 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK6 FANCI 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK6 GCN1 25348397 N/A physical interaction ComPPI
NEK6 PCID2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK6 EML4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK6 KDELR1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK6 RUVBL2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK6 MYO1C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NEK6 DERA 25348397 N/A physical interaction ComPPI
NEK6 KCTD5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NEK6 PHF1 25348397 N/A physical interaction ComPPI
NEK6 PRDX3 25348397 N/A physical interaction ComPPI
NEK6 PTN 25348397 N/A physical interaction ComPPI
NEK6 ARHGAP33 25348397 N/A physical interaction ComPPI
NEK6 RELB 25348397 N/A physical interaction ComPPI
NEK6 ERCC6L2 25348397 N/A physical interaction ComPPI
NEK6 TCF4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NEK6 TASOR2 25348397 N/A physical interaction ComPPI
NEK6 LNX1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NEK6 IHO1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NEK6 INCA1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NEK6 LAMP3 25348397 N/A physical interaction ComPPI
NEK6 IL13RA2 25348397 N/A physical interaction ComPPI
NEK6 SLC3A2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NEK6 UCK2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NEK6 SURF4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NEK6 SMC2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NEK6 MTHFD1L 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NEK6 DNAAF5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NEK6 MYO1A 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NEK6 RBL1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NEK6 NCAPD2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NEK6 AHSA1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NEK6 PTPRD 22305495 24234451 25348397 N/A protein array ComPPI,IntAct
HSCB NEK6 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
NEK6 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
NEK6 HSPA1A 25940345 27898060 N/A N/A OmniPath
NEK6 SGK1 10191262 11096081 12023960 27898060 N/A N/A OmniPath
NEK6 KIF11 19001501 19007248 27898060 N/A N/A OmniPath
NEK9 NEK6 12101123 12840024 17353931 19369195 19690332 20873783 21454704 26186194 27898060 stimulant N/A OmniPath
NEK6 NUP98 21335236 27898060 N/A N/A OmniPath

Visualization










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