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GENE：RGS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RGS2
FullNmae regulator of G protein signaling 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9998
EnsembleID ENSG00000116741
Uniprot P41220

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RGS2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RGS2 GO:0001965,GO:0001975,GO:0003924,GO:0005096,GO:0005515,GO:0005516,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0007049,GO:0007186,GO:0007283,GO:0008277,GO:0009898,GO:0010519,GO:0010614,GO:0010855,GO:0010976,GO:0017148,GO:0043407,GO:0045471,GO:0045744,GO:0048487,GO:0050873,GO:0055119,GO:0060087,GO:0060135,GO:0060452,GO:0061052,GO:0140194,GO:1900924

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RGS2 hsa:5997 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
RGS2 hsa:5997 path:hsa04740 Olfactory transduction - Homo sapiens (human)
RGS2 hsa:5997 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ELAVL1 RGS2 19289500 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR RGS2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 RGS2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 RGS2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 RGS2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC RGS2 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 RGS2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 RGS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RGS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RGS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RGS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RGS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 RGS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 RGS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000096022 RGS2 21168126 23349832 rna interference,inhibition array technology,miRNA interference luciferase reporter assay miRSponge
URS0000096022 RGS2 21168126 23349832 25416803 mrna cleavage,inhibition array technology,miRNA interference luciferase reporter assay TarBase
URS00001D4A78 RGS2 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000040EC3B RGS2 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS00002075FA RGS2 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS00001CC379 RGS2 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS0000345DEB RGS2 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS00002B2B5C RGS2 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000009262D RGS2 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS00004505E4 RGS2 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000017EA6A RGS2 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS00002E177F RGS2 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000016FF9C RGS2 25416803 28735896 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKG1 RGS2 22135298 phosphorylation N/A PhosphoSite
RGS2 GNA15 25361965 interaction type N/A PTMCode2
GNA15 RGS2 25361965 interaction type N/A PTMCode2
RGS2 PRKCG 25361965 interaction type N/A PTMCode2
PRKCG RGS2 25361965 interaction type N/A PTMCode2
RGS2 PRKCA 25361965 interaction type N/A PTMCode2
PRKCA RGS2 25361965 interaction type N/A PTMCode2
RGS2 GNA11 25361965 interaction type N/A PTMCode2
GNA11 RGS2 25361965 interaction type N/A PTMCode2
RGS2 COPB2 25361965 interaction type N/A PTMCode2
COPB2 RGS2 25361965 interaction type N/A PTMCode2
RGS2 GNAI1 25361965 interaction type N/A PTMCode2
GNAI1 RGS2 25361965 interaction type N/A PTMCode2
RGS2 GNAS 25361965 interaction type N/A PTMCode2
GNAS RGS2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GNAI3 RGS2 25348397 N/A physical interaction ComPPI
DYNLL1 RGS2 14525934 16169070 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CIAO1 RGS2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HSPA8 RGS2 14525934 16169070 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ZBTB48 RGS2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KBTBD7 RGS2 25348397 N/A physical interaction ComPPI
EIF3E RGS2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RABAC1 RGS2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPP1R9A RGS2 17464283 24234451 25348397 physical association pull down ComPPI,IntAct
ZYX RGS2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKCA RGS2 11063746 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FZD5 RGS2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SCN5A RGS2 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CTSB RGS2 14525934 16169070 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PRKG1 RGS2 14525934 14608379 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ADRA1A RGS2 14525934 15917235 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
GNAQ RGS2 14525934 25348397 9405622 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
UBB RGS2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBC RGS2 21900206 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
RPS27A RGS2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBA52 RGS2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
DDR1 RGS2 14525934 16169070 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GIT1 RGS2 14525934 16169070 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
COPB1 RGS2 10982407 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
METAP2 RGS2 25348397 N/A physical interaction ComPPI
PRKCB RGS2 11063746 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
XRCC6 RGS2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPP1R9B RGS2 14525934 17464283 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RGS2 PRKCG 11063746 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RGS2 COPB2 10982407 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
RGS2 ADCY5 12604604 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
RGS2 GDE1 10760272 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
RGS2 NINL 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RGS2 ARFGAP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RGS2 WDR74 14525934 16169070 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RGS2 VPS29 14525934 16169070 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RGS2 NIPSNAP1 14525934 16169070 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RGS2 PRKCSH 14525934 16169070 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RGS2 PRKN 14525934 16169070 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RGS2 GNA15 25348397 N/A physical interaction,in vitro,in vivo ComPPI
RGS2 GNAS 14525934 25348397 9794454 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RGS2 IBTK 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RGS2 LRFN1 16169070 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
RGS2 GNAS 25348397 27898060 9794454 N/A physical interaction ComPPI,OmniPath
RGS2 GNAS 25348397 N/A physical interaction ComPPI
RGS2 RAB2A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RGS2 LIG1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RGS2 BBS10 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RGS2 CEP126 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RGS2 REEP5 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RGS2 COMT 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RGS2 EIF3L 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RGS2 IER3IP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RGS2 ZNF579 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RGS2 MON1A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RGS2 HAUS5 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RGS2 CHD3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RGS2 RIN3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RGS2 TUBB2B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RGS2 CRMP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RGS2 METTL18 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RGS2 KLK8 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RGS2 RAP1B 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RGS2 CLTA 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RGS2 ADRB2 25348397 N/A physical interaction ComPPI
RGS2 MTUS2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RGS2 FBXO44 25348397 N/A physical interaction ComPPI
RGS2 DDB1 25348397 N/A physical interaction ComPPI
RGS2 MIPOL1 25348397 N/A physical interaction ComPPI
RGS2 PTPN13 25348397 N/A physical interaction ComPPI
RGS2 STXBP4 25348397 N/A physical interaction ComPPI
RGS2 STRIP1 25348397 N/A physical interaction ComPPI
RGS2 STK26 25348397 N/A physical interaction ComPPI
RGS2 SERPINA10 25348397 N/A physical interaction ComPPI
RGS2 TAF2 25348397 N/A physical interaction ComPPI
RGS2 EGFR 25348397 N/A physical interaction ComPPI
RGS2 MARCHF6 25348397 N/A anti tag coimmunoprecipitation,pull down,physical interaction ComPPI
RGS2 LRRK2 24234451 24794857 25348397 27898060 phosphorylation reaction,colocalization,physical association anti tag coimmunoprecipitation,protein kinase assay,confocal microscopy ComPPI,IntAct,OmniPath
TSPAN15 RGS2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DUSP21 RGS2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RGS2 CALM2 10747990 14525934 N/A experimental interaction detection HPRD
H2BS1 RGS2 24234451 30021884 physical association cross-linking study IntAct
PRKG1 RGS2 14608379 24777815 27898060 stimulant N/A OmniPath
RGS2 GNAI3 27898060 9736641 inhibition N/A OmniPath
RGS2 TRPV6 16895908 27898060 inhibition N/A OmniPath
RGS2 GNAQ 14976183 27898060 9405622 9736641 inhibition N/A OmniPath
RGS2 GNA11 14976183 27898060 inhibition N/A OmniPath

Visualization










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