GENE：ITGB6
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ITGB6 |
| FullNmae | integrin subunit beta 6 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6161 |
| EnsembleID | ENSG00000115221 |
| Uniprot | P18564 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ITGB6 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ITGB6 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ITGB6 | GO:0000902,GO:0001618,GO:0005178,GO:0005515,GO:0005654,GO:0005813,GO:0005886,GO:0005925,GO:0005925,GO:0006954,GO:0006955,GO:0007155,GO:0007160,GO:0007160,GO:0007179,GO:0007229,GO:0008305,GO:0009615,GO:0009897,GO:0009986,GO:0016477,GO:0030054,GO:0033627,GO:0033627,GO:0034685,GO:0034685,GO:0042060,GO:0043129,GO:0043235,GO:0043588,GO:0046718,GO:0046872,GO:0048286,GO:0055091,GO:0060022,GO:0060348,GO:0060395,GO:0060435,GO:0061520,GO:0070166,GO:0071479,GO:0071604,GO:1901388 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ITGB6 | hsa:3694 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| ITGB6 | hsa:3694 | path:hsa04510 | Focal adhesion - Homo sapiens (human) |
| ITGB6 | hsa:3694 | path:hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
| ITGB6 | hsa:3694 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| ITGB6 | hsa:3694 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| ITGB6 | hsa:3694 | path:hsa05410 | Hypertrophic cardiomyopathy - Homo sapiens (human) |
| ITGB6 | hsa:3694 | path:hsa05412 | Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human) |
| ITGB6 | hsa:3694 | path:hsa05414 | Dilated cardiomyopathy - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ITGAV | ITGB6 | 26192618 | association | N/A | ACSN |
| MAPK1 | ITGB6 | 11857080 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CTNNB1 | ITGB6 | 23180781 26515729 | physical association | anti tag coimmunoprecipitation | InnateDB |
| ITGB6 | TGFB1 | 20870411 23331499 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| FLNB | ITGB6 | 20005715 | interaction type | N/A | PSP,SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ITGB6 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | ITGB6 | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA3 | ITGB6 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | ITGB6 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ITGB6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ITGB6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ITGB6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ITGB6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ITGB6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | ITGB6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ITGB6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ITGB6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | ITGB6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | ITGB6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ITGAV | ITGB6 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGB6 | ITGAV | 25361965 | interaction type | N/A | PTMCode2 |
| TGFB1 | ITGB6 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGB6 | TGFB1 | 25361965 | interaction type | N/A | PTMCode2 |
| VTN | ITGB6 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGB6 | VTN | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TGFB1 | ITGB6 | 10025398 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| MAPK1 | ITGB6 | 25348397 | N/A | physical interaction | ComPPI |
| FHL2 | ITGB6 | 10906324 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD |
| FLNA | ITGB6 | 25348397 | N/A | physical interaction | ComPPI |
| ITGAV | ITGB6 | 14525934 1532572 21677751 24234451 25348397 25383667 8120056 | physical association | transmission electron microscopy,experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,ion exchange chromatography,in vivo | ComPPI,HPRD,IntAct |
| VTN | ITGB6 | 14525934 25348397 8120056 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| FLNB | ITGB6 | 25348397 | N/A | physical interaction | ComPPI |
| ITGB6 | FN1 | 14525934 1532572 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| HMGN2 | ITGB6 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| FN1 | ITGB6 | 1532572 1694173 17015452 18480047 27898060 | stimulant | N/A | OmniPath |
| ITGB6 | TGFB1 | 10025398 20870411 27898060 | stimulant | N/A | OmniPath |
| ITGB6 | MAPK1 | 11857080 27898060 | N/A | N/A | OmniPath |
| MAPK1 | ITGB6 | 11857080 27898060 | N/A | N/A | OmniPath |
| ITGA5 | ITGB6 | 1532572 27898060 | N/A | N/A | OmniPath |