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GENE：SOCS4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SOCS4
FullNmae suppressor of cytokine signaling 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:19392
EnsembleID ENSG00000180008
Uniprot Q8WXH5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SOCS4 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SOCS4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SOCS4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SOCS4 GO:0005515,GO:0005942,GO:0007175,GO:0016567,GO:0032436,GO:0035556,GO:0046854,GO:0046935

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SOCS4 hsa:122809 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
SOCS4 hsa:122809 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
SOCS4 hsa:122809 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)
SOCS4 hsa:122809 path:hsa04930 Type II diabetes mellitus - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SOCS4 ELOB 17997974 23180781 physical association x-ray crystallography InnateDB
SOCS4 ELOC 17997974 23180781 physical association x-ray crystallography InnateDB
SOCS4 EGFR 17997974 23180781 physical association isothermal titration calorimetry InnateDB
SOCS4 JAK2 17997974 23180781 physical association isothermal titration calorimetry InnateDB
SOCS4 KIT 17997974 23180781 physical association isothermal titration calorimetry InnateDB

Source Target Pmid Interactiontype Methods Database
AR SOCS4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 SOCS4 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 SOCS4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SOCS4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SOCS4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PPARG SOCS4 20357037 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 SOCS4 20486857 rna interference,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000122ED0 SOCS4 20486857 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,western blot,western blot,northern blot,quantitative reverse transcription pcr,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002C0FCB SOCS4 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000EED18 SOCS4 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000009262D SOCS4 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS00003D5391 SOCS4 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
TEKT4 SOCS4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CUL5 SOCS4 25348397 N/A physical interaction ComPPI
FRS3 SOCS4 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping ComPPI,IntAct
PALS1 SOCS4 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
SPRY1 SOCS4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GRB2 SOCS4 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
PIK3R3 SOCS4 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
EGFR SOCS4 25348397 N/A physical interaction ComPPI
NR4A1 SOCS4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TNK2 SOCS4 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
ELOB SOCS4 25348397 N/A physical interaction ComPPI
ELOC SOCS4 16643902 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
VWF SOCS4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CNMD SOCS4 25348397 N/A physical interaction ComPPI
MDFIC SOCS4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PINK1 SOCS4 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
SOCS4 PLPP6 25348397 N/A physical interaction ComPPI
SOCS4 LDHAL6B 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
SOCS4 RBP7 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
SOCS4 EGFR 17997974 27898060 N/A N/A OmniPath
SOCS4 KIT 17997974 27898060 N/A N/A OmniPath
SOCS4 JAK2 17997974 27898060 inhibition N/A OmniPath
SOCS4 ELOC 16643902 17997974 19385048 27898060 N/A N/A OmniPath
SOCS4 ELOB 17997974 19385048 27898060 N/A N/A OmniPath

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