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GENE：CLTB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CLTB
FullNmae clathrin light chain B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2091
EnsembleID ENSG00000175416
Uniprot P09497

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CLTB lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
CLTB lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CLTB immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CLTB autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CLTB GO:0005198,GO:0005515,GO:0005802,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0006886,GO:0030118,GO:0030118,GO:0030125,GO:0030130,GO:0030132,GO:0030672,GO:0032050,GO:0042277,GO:0043231,GO:0045334,GO:0060170,GO:0072583,GO:0098835,GO:0099631

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CLTB hsa:1212 path:hsa04142 Lysosome - Homo sapiens (human)
CLTB hsa:1212 path:hsa04144 Endocytosis - Homo sapiens (human)
CLTB hsa:1212 path:hsa04721 Synaptic vesicle cycle - Homo sapiens (human)
CLTB hsa:1212 path:hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
CLTB hsa:1212 path:hsa05016 Huntington disease - Homo sapiens (human)
CLTB hsa:1212 path:hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 CLTB 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 CLTB 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CLTB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CLTB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CLTB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 CLTB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CLTB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CLTB 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 CLTB 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000085F64 CLTB 23708386 25416803 mrna cleavage,inhibition clip TarBase
URS000007A060 CLTB 23708386 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GRK2 CLTB 22135298 phosphorylation N/A PhosphoSite
CSNK2A1 CLTB 25361965 interaction type N/A PTMCode2
CLTB CSNK2A1 25361965 interaction type N/A PTMCode2
CLTC CLTB 25361965 interaction type N/A PTMCode2
CLTB CLTC 25361965 interaction type N/A PTMCode2
CLTB HIP1 25361965 interaction type N/A PTMCode2
HIP1 CLTB 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAPRE1 CLTB 25348397 N/A physical interaction ComPPI
HSPA8 CLTB 24234451 25348397 29568061 association pull down ComPPI,IntAct
GMNN CLTB 25348397 N/A physical interaction ComPPI
PPP1CB CLTB 25348397 N/A physical interaction ComPPI
APPL1 CLTB 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
DAB2 CLTB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TCF20 CLTB 25348397 N/A physical interaction ComPPI
FLNA CLTB 25348397 N/A physical interaction ComPPI
DLD CLTB 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PICALM CLTB 25348397 N/A physical interaction ComPPI
PDAP1 CLTB 25348397 N/A physical interaction ComPPI
NUMB CLTB 25348397 N/A physical interaction ComPPI
CSNK2A1 CLTB 14525934 25348397 3128543 N/A experimental interaction detection,in vitro ComPPI,HPRD
IQGAP1 CLTB 25348397 N/A physical interaction ComPPI
PDLIM7 CLTB 25348397 N/A physical interaction ComPPI
AP2A2 CLTB 25348397 N/A physical interaction ComPPI
MYO18A CLTB 25348397 N/A physical interaction ComPPI
CLTC CLTB 12426379 14525934 15533940 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
AP2A1 CLTB 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
EPS15 CLTB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AP2B1 CLTB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARRB2 CLTB 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CSNK2A2 CLTB 14525934 25348397 2874131 3128543 N/A experimental interaction detection,in vitro ComPPI,HPRD
STON2 CLTB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCAPG2 CLTB 25348397 N/A physical interaction ComPPI
OCRL CLTB 24234451 25107275 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SMC3 CLTB 25348397 N/A physical interaction ComPPI
AP3D1 CLTB 25348397 N/A physical interaction ComPPI
MYO6 CLTB 25348397 N/A physical interaction ComPPI
PQBP1 CLTB 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
WNK1 CLTB 25348397 N/A physical interaction ComPPI
HSPE1 CLTB 25348397 N/A physical interaction ComPPI
SEC13 CLTB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AP2M1 CLTB 25348397 N/A physical interaction ComPPI
GAK CLTB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AP2S1 CLTB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLINT1 CLTB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HIP1 CLTB 1189126 14525934 15533940 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
CLTCL1 CLTB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SYNPO CLTB 25348397 N/A physical interaction ComPPI
ANLN CLTB 25348397 N/A physical interaction ComPPI
VPS33A CLTB 25348397 N/A physical interaction ComPPI
NES CLTB 25348397 N/A physical interaction ComPPI
ACTR2 CLTB 25348397 N/A physical interaction ComPPI
PAN2 CLTB 25348397 N/A physical interaction ComPPI
CLTB FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
CLTB TP53 25348397 N/A physical interaction ComPPI
CLTB NCAPD3 25348397 N/A physical interaction ComPPI
CLTB PI4K2A 25348397 N/A physical interaction ComPPI
CLTB PNPT1 25348397 N/A physical interaction ComPPI
CLTB CLTA 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CLTB CAPZA2 25348397 N/A physical interaction ComPPI
CLTB DBN1 25348397 N/A physical interaction ComPPI
CLTB MYH9 25348397 N/A physical interaction ComPPI
CLTB SEC16A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLTB LIMA1 25348397 N/A physical interaction ComPPI
CLTB GTSE1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLTB MYO5C 25348397 N/A physical interaction ComPPI
CLTB MYO19 25348397 N/A physical interaction ComPPI
CLTB MIDEAS 25348397 N/A physical interaction ComPPI
CLTB ARX 25348397 N/A physical interaction ComPPI
CLTB PIK3C2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLTB HIP1R 11889126 1189126 14525934 15533940 24234451 25348397 26496610 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
CLTB AAK1 25348397 N/A physical interaction ComPPI
CLTB TNRC6A 25348397 N/A physical interaction ComPPI
CLTB BMP2K 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLTB DENND1A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLTB SLC25A19 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLTB FCHO2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLTB FAM83B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLTB VPS33B 25348397 N/A physical interaction ComPPI
CLTB VPS41 25348397 N/A physical interaction ComPPI
CLTB EIF3CL 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CLTB TES 25348397 N/A physical interaction ComPPI
PTPN23 CLTB 25348397 N/A physical interaction ComPPI
CLTB CALM2 14525934 7836475 N/A experimental interaction detection HPRD
HTR4 CLTB 24234451 28298427 physical association ubiquitin reconstruction IntAct
GRK2 CLTB 22704991 27898060 N/A N/A OmniPath

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