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GENE：ADAMTS5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ADAMTS5
FullNmae ADAM metallopeptidase with thrombospondin type 1 motif 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:221
EnsembleID ENSG00000154736
Uniprot Q9UNA0

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ADAMTS5 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ADAMTS5 GO:0003180,GO:0003184,GO:0003203,GO:0004175,GO:0004222,GO:0004222,GO:0004222,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0006508,GO:0006508,GO:0007520,GO:0008201,GO:0008233,GO:0008237,GO:0008270,GO:0022617,GO:0022617,GO:0030198,GO:0031012,GO:0042742,GO:0042802,GO:0050840,GO:0062023,GO:0120163

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR ADAMTS5 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 ADAMTS5 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 ADAMTS5 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
EGR1 ADAMTS5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ADAMTS5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 ADAMTS5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 ADAMTS5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SIRT1 ADAMTS5 21337390 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 ADAMTS5 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000007340 ADAMTS5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 ADAMTS5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 ADAMTS5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 ADAMTS5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 ADAMTS5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E ADAMTS5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 ADAMTS5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000381CEC ADAMTS5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002F74F1 ADAMTS5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000308E4D ADAMTS5 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000028D811 ADAMTS5 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000338542 ADAMTS5 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F ADAMTS5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 ADAMTS5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 ADAMTS5 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ACAN ADAMTS5 25361965 interaction type N/A PTMCode2
ADAMTS5 ACAN 25361965 interaction type N/A PTMCode2
MMP13 ADAMTS5 25361965 interaction type N/A PTMCode2
ADAMTS5 MMP13 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MMP13 ADAMTS5 11032846 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
TIMP3 ADAMTS5 19643179 22406378 24234451 25348397 27898060 protein cleavage protease assay ComPPI,IntAct,OmniPath
ADAMTS5 ACAN 11854269 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD

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