GENE：AREG
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | AREG |
| FullNmae | amphiregulin |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:651 |
| EnsembleID | ENSG00000109321 |
| Uniprot | P15514 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| AREG | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| AREG | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| AREG | GO:0005125,GO:0005154,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005634,GO:0005789,GO:0007173,GO:0007173,GO:0007186,GO:0007267,GO:0008083,GO:0008284,GO:0008284,GO:0009986,GO:0010838,GO:0012507,GO:0014009,GO:0030297,GO:0030669,GO:0031175,GO:0032355,GO:0033116,GO:0038134,GO:0042542,GO:0043434,GO:0045668,GO:0048018,GO:0050731,GO:0051384,GO:0051591,GO:0060598,GO:0060744,GO:0060749,GO:0060750 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| AREG | hsa:374 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| AREG | hsa:374 | path:hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| AREG | hsa:374 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| AREG | hsa:374 | path:hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| AREG | hsa:374 | path:hsa05210 | Colorectal cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AREG | EGFR | 10085134 10209155 20430953 21071413 23010081 23331499 26192618 | interaction type,stimulation | N/A | ACSN,SignaLink,SignaLink |
| PTGS2 | AREG | 18633355 20138012 21847358 23010081 23390297 25987127 26192618 | interaction type | N/A | ACSN |
| AREG | KRTAP10-3 | 23180781 25416956 | physical association | two hybrid | InnateDB |
| AREG | AREG | 10085134 10209155 20513444 26467481 | bind,up-regulates,up-regulates activity | N/A | Signor |
| AREG | ERBB2 | 23331499 7679104 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | AREG | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ESR1 | AREG | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | AREG | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | AREG | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | AREG | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | AREG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | AREG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | AREG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | AREG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | AREG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| BRCA1 | AREG | 20103632 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFIL3 | AREG | 1620116 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | AREG | 14742435 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | AREG | 14742435 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CREB1 | AREG | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HOXB13 | AREG | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | AREG | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RARA | AREG | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | AREG | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD3 | AREG | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD4 | AREG | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | AREG | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000EED18 | AREG | 22815788 25416803 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr | TarBase |
| URS000008DA94 | AREG | 24762440 25416803 | mrna cleavage,inhibition | array technology,experimental interaction detection,western blot,rna immunoprecipitation,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AREG | EGFR | 25361965 | interaction type | N/A | PTMCode2 |
| EGFR | AREG | 25361965 | interaction type | N/A | PTMCode2 |
| AREG | MMP9 | 25361965 | interaction type | N/A | PTMCode2 |
| MMP9 | AREG | 25361965 | interaction type | N/A | PTMCode2 |
| AREG | CCND3 | 25361965 | interaction type | N/A | PTMCode2 |
| CCND3 | AREG | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KRTAP10-8 | AREG | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| S100A4 | AREG | 19740107 24234451 25348397 | N/A | far western blotting,pull down | ComPPI,IntAct |
| S100A2 | AREG | 19740107 24234451 25348397 | N/A | far western blotting | ComPPI,IntAct |
| WT1 | AREG | 10490105 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| EGFR | AREG | 10085134 14525934 25348397 | N/A | affinity chromatography technology,experimental interaction detection,physical interaction,biochemical,in vivo | ComPPI,HPRD |
| UBQLN4 | AREG | 14525934 16713569 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid | ComPPI,HPRD,IntAct |
| MMP9 | AREG | 10389762 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| CCND3 | AREG | 11469683 14525934 24234451 25241761 25348397 | physical association | experimental interaction detection,physical interaction,in vivo,proximity ligation assay | ComPPI,HPRD,IntAct |
| ICAM1 | AREG | 25348397 | N/A | physical interaction | ComPPI |
| AREG | APP | 25348397 | N/A | physical interaction | ComPPI |
| AREG | DNAAF10 | 23844004 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| AREG | KRTAP10-3 | 25348397 | N/A | physical interaction | ComPPI |
| AREG | ADCY9 | 25348397 | N/A | physical interaction | ComPPI |
| AREG | NEURL4 | 25348397 | N/A | physical interaction | ComPPI |
| AREG | SNX11 | 25348397 | N/A | physical interaction | ComPPI |
| AREG | CYSRT1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| S100A5 | AREG | 19740107 24234451 25348397 | N/A | far western blotting | ComPPI,IntAct |
| SRC | AREG | 17251915 27898060 | stimulant | N/A | OmniPath |
| AREG | EGFR | 10085134 10209155 1020916 20513444 27898060 | stimulant | N/A | OmniPath |
| AREG | ERBB2 | 27898060 7679104 | stimulant | N/A | OmniPath |
| AREG | ERBB3 | 27898060 8702723 | N/A | N/A | OmniPath |