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GENE：ASS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ASS1
FullNmae argininosuccinate synthase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:758
EnsembleID ENSG00000130707
Uniprot P00966

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ASS1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ASS1 GO:0000050,GO:0000050,GO:0000050,GO:0000052,GO:0000053,GO:0000053,GO:0001822,GO:0001889,GO:0003723,GO:0004055,GO:0004055,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005741,GO:0005829,GO:0005829,GO:0006526,GO:0006526,GO:0006526,GO:0006531,GO:0006953,GO:0007494,GO:0007584,GO:0007623,GO:0009410,GO:0010043,GO:0010046,GO:0015643,GO:0016597,GO:0032355,GO:0042802,GO:0043204,GO:0045429,GO:0060416,GO:0060539,GO:0070062,GO:0070852,GO:0071222,GO:0071230,GO:0071242,GO:0071320,GO:0071346,GO:0071356,GO:0071377,GO:0071400,GO:0071418,GO:0071499,GO:0071549,GO:1903038

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ASS1 hsa:445 path:hsa00220 Arginine biosynthesis - Homo sapiens (human)
ASS1 hsa:445 path:hsa00250 Alanine, aspartate and glutamate metabolism - Homo sapiens (human)
ASS1 hsa:445 path:hsa01100 Metabolic pathways - Homo sapiens (human)
ASS1 hsa:445 path:hsa01230 Biosynthesis of amino acids - Homo sapiens (human)
ASS1 hsa:445 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR ASS1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 ASS1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 ASS1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
NR1I2 ASS1 19129222 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 ASS1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ASS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ASS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ASS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ASS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ASS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ASS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ASS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ASS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ASS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ASS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A ASS1 19934275 trascriptional regulation,stimulation inferred by curator TFlink
MYC ASS1 19934275 trascriptional regulation,stimulation inferred by curator TFlink
SP4 ASS1 19934275 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000005481D ASS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C85B2 ASS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000076B539 ASS1 21572407 23313552 23824327 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000085F64 ASS1 23313552 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
KPNA2 ASS1 25348397 N/A physical interaction ComPPI
LDHB ASS1 25348397 N/A physical interaction ComPPI
ASS1 ARAF 12620389 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ASS1 AKTIP 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ASS1 ELN 1372742 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
ASS1 MYC 17314511 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ASS1 TERF1 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
ASS1 TERF2 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
ASS1 USP4 25348397 N/A physical interaction ComPPI
ASS1 APP 25348397 N/A physical interaction ComPPI
ASS1 SPR 25348397 N/A physical interaction ComPPI
ASS1 GIT2 25348397 N/A physical interaction ComPPI
ASS1 MLH1 20706999 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ASS1 JAK2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ASS1 PTPN1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ASS1 FBXO6 25348397 N/A physical interaction ComPPI
ASS1 LATS1 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ASS1 ATG3 25348397 N/A physical interaction ComPPI
ASS1 CAPN1 25348397 N/A physical interaction ComPPI
ASS1 EIF4E 25348397 N/A physical interaction ComPPI
ASS1 GBP2 25348397 N/A physical interaction ComPPI
ASS1 GSS 25348397 N/A physical interaction ComPPI
ASS1 MVD 25348397 N/A physical interaction ComPPI
ASS1 CTSA 25348397 N/A physical interaction ComPPI
ASS1 DLD 25348397 N/A physical interaction ComPPI
ASS1 HSPA9 25348397 N/A physical interaction ComPPI
ASS1 RPL23 25348397 N/A physical interaction ComPPI
ASS1 ADK 25348397 N/A physical interaction ComPPI
ASS1 ALDOA 25348397 N/A physical interaction ComPPI
ASS1 ARHGDIA 25348397 N/A physical interaction ComPPI
ASS1 ANXA11 25348397 N/A physical interaction ComPPI
ASS1 ASNS 25348397 N/A physical interaction ComPPI
ASS1 CENPK 25348397 N/A physical interaction ComPPI
ASS1 DAZAP1 25348397 N/A physical interaction ComPPI
ASS1 FH 25348397 N/A physical interaction ComPPI
ASS1 FSCN1 25348397 N/A physical interaction ComPPI
ASS1 GAPDH 25348397 N/A physical interaction ComPPI
ASS1 GSR 25348397 N/A physical interaction ComPPI
ASS1 HSPH1 25348397 N/A physical interaction ComPPI
ASS1 HTRA2 25348397 N/A physical interaction ComPPI
ASS1 MTAP 25348397 N/A physical interaction ComPPI
ASS1 PAICS 25348397 N/A physical interaction ComPPI
ASS1 PHGDH 25348397 N/A physical interaction ComPPI
ASS1 PIR 25348397 N/A physical interaction ComPPI
ASS1 PKM 25348397 N/A physical interaction ComPPI
ASS1 PRDX1 25348397 N/A physical interaction ComPPI
ASS1 PRDX6 25348397 N/A physical interaction ComPPI
ASS1 TPI1 25348397 N/A physical interaction ComPPI
ASS1 PDCD6IP 25348397 N/A physical interaction ComPPI
ASS1 PFKL 25348397 N/A physical interaction ComPPI
ASS1 PRDX2 25348397 N/A physical interaction ComPPI
ASS1 RUVBL2 25348397 N/A physical interaction ComPPI
ASS1 STIP1 25348397 N/A physical interaction ComPPI
ASS1 TAGLN2 25348397 N/A physical interaction ComPPI
ASS1 TKT 25348397 N/A physical interaction ComPPI
ASS1 TXN 25348397 N/A physical interaction ComPPI
ASS1 SCLT1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ASS1 RAB2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ASS1 SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ASS1 USF1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ASS1 PC 25348397 N/A physical interaction ComPPI
ASS1 SIRT3 25348397 N/A physical interaction ComPPI
ASS1 TRIM25 25348397 N/A physical interaction ComPPI
ASS1 HNRNPL 25348397 N/A physical interaction ComPPI
ASS1 NMRAL1 17496144 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ASS1 YWHAZ 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
ASS1 CDR2 11988016 24234451 25348397 physical association two hybrid ComPPI,IntAct
ASS1 MBD2 24234451 27593931 association chromatin immunoprecipitation assay IntAct

Visualization










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