Gene Information gene info

GENE:ELK4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ELK4
FullNmae ETS transcription factor ELK4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3326
EnsembleID ENSG00000158711
Uniprot P28324

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ELK4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ELK4 GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0000981,GO:0001228,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0030154,GO:0045944,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ELK4 hsa:2005 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
ELK4 hsa:2005 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
ELK4 hsa:2005 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAPK8 ELK4 23180781 23331499 9020136 phosphorylation reaction,stimulation in-gel kinase assay InnateDB,SignaLink,SignaLink
MAPK3 ELK4 23180781 23331499 9020136 phosphorylation reaction,stimulation in-gel kinase assay InnateDB,SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 ELK4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ELK4 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 ELK4 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ELK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ELK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ELK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ELK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ELK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ELK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ELK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ELK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
AR ELK4 18469865 trascriptional regulation,stimulation inferred by curator TFlink
BRCA1 ELK4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005651EE ELK4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 ELK4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000018C928 ELK4 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000236310 ELK4 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000171CD1 ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000F0F49 ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004BCD9C ELK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040EC3B ELK4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000338542 ELK4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001D69F6 ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004CCA62 ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000237AF9 ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006B702 ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 ELK4 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000202460 ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000000E601 ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 ELK4 20371350 22012620 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000008F0CF ELK4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 ELK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000211070 ELK4 22012620 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C5BAA ELK4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001EE123 ELK4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000759FD9 ELK4 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00004719AB ELK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C7662 ELK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 ELK4 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000057A7C ELK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003A5E54 ELK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005E1A16 ELK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000140295 ELK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000059EB31 ELK4 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003AD231 ELK4 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001B9F58 ELK4 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005485E8 ELK4 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002C02E4 ELK4 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075BDAA ELK4 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000049FAE8 ELK4 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E0524 ELK4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000122F23 ELK4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002B0B46 ELK4 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK2 ELK4 22135298 phosphorylation N/A PhosphoSite
MAPK11 ELK4 25361965 interaction type N/A PTMCode2
ELK4 MAPK11 25361965 interaction type N/A PTMCode2
SRF ELK4 25361965 interaction type N/A PTMCode2
ELK4 SRF 25361965 interaction type N/A PTMCode2
FOS ELK4 25361965 interaction type N/A PTMCode2
ELK4 FOS 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAPK1 ELK4 25348397 N/A physical interaction ComPPI
MAPK8 ELK4 25348397 N/A physical interaction ComPPI
MAPK3 ELK4 25348397 N/A physical interaction ComPPI
SRF ELK4 11406578 11846562 14525934 17200232 24234451 25348397 7854423 N/A two hybrid,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
HNRNPL ELK4 25348397 N/A physical interaction ComPPI
MAPK7 ELK4 10473620 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ID3 ELK4 10022839 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ID1 ELK4 10022839 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ELK4 MAPK11 25348397 N/A in vitro ComPPI
ELK4 ID2 10022839 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ELK4 BRCA1 25348397 N/A physical interaction ComPPI
ELK4 ELAVL1 25348397 N/A physical interaction ComPPI
ELK4 TRIM25 25348397 N/A physical interaction ComPPI
ELK4 SIRT7 22722849 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELK4 FOS 14525934 7540136 N/A experimental interaction detection HPRD
CDK2 ELK4 26028036 27898060 N/A N/A OmniPath
MAPK3 ELK4 27898060 9020136 stimulant N/A OmniPath
ELK4 MAPK3 27898060 9020136 N/A N/A OmniPath
MAPK8 ELK4 27898060 9020136 stimulant N/A OmniPath
PCSK7 ELK4 27898060 9130707 stimulant N/A OmniPath

Visualization