Gene Information gene info

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GENE：EXO1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EXO1
FullNmae exonuclease 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3511
EnsembleID ENSG00000174371
Uniprot Q9UQ84

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EXO1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EXO1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EXO1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EXO1 GO:0002455,GO:0003677,GO:0003682,GO:0004523,GO:0004527,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005886,GO:0006281,GO:0006298,GO:0006298,GO:0006298,GO:0006298,GO:0006298,GO:0006298,GO:0006310,GO:0006310,GO:0008409,GO:0008409,GO:0016446,GO:0016604,GO:0017108,GO:0035312,GO:0035312,GO:0045145,GO:0045190,GO:0046872,GO:0048256,GO:0051321,GO:0051908,GO:0090656

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EXO1 hsa:9156 path:hsa03430 Mismatch repair - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 EXO1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 EXO1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 EXO1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 EXO1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 EXO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA EXO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EXO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 EXO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 EXO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EXO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TCF7L1 EXO1 19698732 trascriptional regulation,stimulation inferred by curator TFlink
TCF3 EXO1 19698732 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 EXO1 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYB EXO1 N/A trascriptional regulation,stimulation inferred by curator TFlink
SP1 EXO1 N/A trascriptional regulation,stimulation inferred by curator TFlink
SP3 EXO1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 EXO1 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS00000ED600 EXO1 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS00001DE669 EXO1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
EXO1 BLM 25361965 interaction type N/A PTMCode2
BLM EXO1 25361965 interaction type N/A PTMCode2
EXO1 PCNA 25361965 interaction type N/A PTMCode2
PCNA EXO1 25361965 interaction type N/A PTMCode2
MSH2 EXO1 25361965 interaction type N/A PTMCode2
EXO1 MSH2 25361965 interaction type N/A PTMCode2
MSH3 EXO1 25361965 interaction type N/A PTMCode2
EXO1 MSH3 25361965 interaction type N/A PTMCode2
RAD50 EXO1 25361965 interaction type N/A PTMCode2
EXO1 RAD50 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I EXO1 25348397 N/A physical interaction ComPPI
KPNA4 EXO1 25348397 N/A physical interaction ComPPI
PCNA EXO1 25348397 N/A physical interaction ComPPI
MSH3 EXO1 25348397 N/A physical interaction,in vitro,in vivo ComPPI
YWHAG EXO1 25348397 N/A physical interaction ComPPI
WDR83 EXO1 25348397 N/A physical interaction ComPPI
KPNB1 EXO1 25348397 N/A physical interaction ComPPI
YWHAB EXO1 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAZ EXO1 25348397 N/A physical interaction ComPPI
CFTR EXO1 17110338 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
BLM EXO1 18971343 24234451 25348397 N/A pull down,physical interaction ComPPI,IntAct
ATM EXO1 25348397 N/A physical interaction ComPPI
RPA2 EXO1 21052091 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
YWHAQ EXO1 25348397 N/A physical interaction ComPPI
RBBP8 EXO1 21052091 24234451 25348397 26807646 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAH EXO1 25348397 N/A physical interaction ComPPI
SFN EXO1 25348397 N/A physical interaction ComPPI
YWHAE EXO1 25348397 N/A physical interaction ComPPI
TRIM25 EXO1 25348397 N/A physical interaction ComPPI
H2AX EXO1 21052091 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
EXO1 PMS2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
EXO1 MSH2 10835383 10856833 11427529 11429708 14676842 16189514 17602897 17720936 18157157 19015241 22222486 25348397 27898060 9207118 9788596 9826691 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI,OmniPath
EXO1 MLH1 11427529 11429708 11481425 11901110 12042306 12529393 14676842 16189514 17148452 17602897 18157157 19015241 21533173 22222486 23435383 25348397 27898060 N/A anti tag coimmunoprecipitation,physical interaction,in vitro,in vivo ComPPI,OmniPath
EXO1 PMS2CL 25348397 N/A physical interaction ComPPI
EXO1 PMS1 25348397 N/A physical interaction ComPPI
EXO1 CD14 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXO1 COMT 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXO1 LLGL2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXO1 MYEF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXO1 ACTR5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXO1 KLC3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXO1 SENP6 25348397 N/A physical interaction ComPPI
PLEC EXO1 24234451 30021884 physical association cross-linking study IntAct
ATR EXO1 17525332 18048416 27898060 inhibition,stimulant N/A OmniPath
ATM EXO1 17525332 20019063 27898060 inhibition,stimulant N/A OmniPath

Visualization










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