Gene Information gene info

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GENE：HK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HK2
FullNmae hexokinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4923
EnsembleID ENSG00000159399
Uniprot P52789

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HK2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HK2 GO:0001666,GO:0001678,GO:0002931,GO:0004340,GO:0004340,GO:0004340,GO:0004396,GO:0005515,GO:0005524,GO:0005536,GO:0005739,GO:0005739,GO:0005741,GO:0005813,GO:0005829,GO:0005829,GO:0005829,GO:0006002,GO:0006006,GO:0006096,GO:0006096,GO:0007595,GO:0008637,GO:0008865,GO:0008865,GO:0016020,GO:0016529,GO:0035795,GO:0043231,GO:0045766,GO:0046324,GO:0046835,GO:0051156,GO:0051156,GO:0061621,GO:0072655,GO:0072656,GO:1904925,GO:1990830,GO:2000378

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HK2 hsa:3099 path:hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human)
HK2 hsa:3099 path:hsa00051 Fructose and mannose metabolism - Homo sapiens (human)
HK2 hsa:3099 path:hsa00052 Galactose metabolism - Homo sapiens (human)
HK2 hsa:3099 path:hsa00500 Starch and sucrose metabolism - Homo sapiens (human)
HK2 hsa:3099 path:hsa00520 Amino sugar and nucleotide sugar metabolism - Homo sapiens (human)
HK2 hsa:3099 path:hsa00524 Neomycin, kanamycin and gentamicin biosynthesis - Homo sapiens (human)
HK2 hsa:3099 path:hsa01100 Metabolic pathways - Homo sapiens (human)
HK2 hsa:3099 path:hsa01200 Carbon metabolism - Homo sapiens (human)
HK2 hsa:3099 path:hsa01250 Biosynthesis of nucleotide sugars - Homo sapiens (human)
HK2 hsa:3099 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
HK2 hsa:3099 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
HK2 hsa:3099 path:hsa04930 Type II diabetes mellitus - Homo sapiens (human)
HK2 hsa:3099 path:hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human)
HK2 hsa:3099 path:hsa05131 Shigellosis - Homo sapiens (human)
HK2 hsa:3099 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR HK2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 HK2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 HK2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 HK2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 HK2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 HK2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HIF1A HK2 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
FOXA1 HK2 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 HK2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SREBF1 HK2 14747281 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
TFAP2C HK2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 HK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 HK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 HK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF HK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 HK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 HK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 HK2 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A HK2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001F0C23 HK2 22593586 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000008A99 HK2 22354042 22593586 23376635 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000008A99 HK2 22354042 22593586 22691140 23376635 24033605 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001F0C23 HK2 22593586 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00000ED600 HK2 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS0000338542 HK2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000122ED0 HK2 19088304 25416803 28025745 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00005651EE HK2 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
SRC HK2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
TOMM22 HK2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TPP2 HK2 25348397 N/A physical interaction ComPPI
MAGEA12 HK2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
HK2 SLC2A4 14525934 16396496 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HK2 PRKCE 12663490 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HK2 UBQLN4 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
HK2 UBQLN1 14525934 16189514 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
HK2 PTGDS 11068878 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
HK2 ZBTB17 11068878 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
HK2 ELAVL1 25348397 N/A physical interaction ComPPI
HK2 ITGA4 25348397 N/A physical interaction ComPPI
HK2 PRKN 25348397 N/A physical interaction ComPPI
HK2 FBXO6 25348397 N/A physical interaction ComPPI
HK2 FNTA 25348397 N/A physical interaction ComPPI
HK2 H2AZ2 25348397 N/A physical interaction ComPPI
HK2 HEXB 25348397 N/A physical interaction ComPPI
HK2 IPO5 25348397 N/A physical interaction ComPPI
HK2 NUBP1 25348397 N/A physical interaction ComPPI
HK2 PDLIM1 25348397 N/A physical interaction ComPPI
HK2 WDR61 25348397 N/A physical interaction ComPPI
HK2 PYGL 25348397 N/A physical interaction ComPPI
HK2 EGFR 25348397 N/A physical interaction ComPPI
HK2 MAGEA3 25348397 N/A physical interaction ComPPI
HK2 CNBP 25348397 N/A physical interaction ComPPI
HK2 HYOU1 25348397 N/A physical interaction ComPPI
HK2 PPME1 25348397 N/A physical interaction ComPPI
HK2 SRM 25348397 N/A physical interaction ComPPI
HK2 TBCB 25348397 N/A physical interaction ComPPI
HK2 MARS1 25348397 N/A physical interaction ComPPI
HK2 SEPTIN10 25348397 N/A physical interaction ComPPI
HK2 SEPTIN6 25348397 N/A physical interaction ComPPI
HK2 NTRK1 25348397 N/A physical interaction ComPPI
HK2 HSP90AA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HK2 HSP90AA2P 25348397 N/A physical interaction ComPPI
HK2 RAD18 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HK2 IRF3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
HK2 FOXH1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
HK2 FOXI2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
HK2 FOXL1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
HK2 FOXL2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
HK2 COQ9 25348397 N/A physical interaction ComPPI
HK2 NDUFA4 25348397 N/A physical interaction ComPPI
HK2 NMES1 25348397 N/A physical interaction ComPPI
HK2 HK1 25348397 N/A physical interaction ComPPI
HK2 HK3 25348397 N/A physical interaction ComPPI
HK2 TES 25348397 N/A physical interaction ComPPI
HK2 TIGAR 23185017 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HK2 ENO1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
HK2 VCAM1 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
HK2 HSCB 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
HK2 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
HK2 COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HK2 TOMM20 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HK2 NDUFAF8 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
HK2 NDUFAF4 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
HK2 COX6B1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
NUDCD3 HK2 25348397 N/A physical interaction ComPPI
FOXB1 HK2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
BUB3 HK2 25348397 N/A physical interaction ComPPI
ARIH2 HK2 25348397 N/A physical interaction ComPPI
MGST3 HK2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct

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