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GENE：SPRED2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SPRED2
FullNmae sprouty related EVH1 domain containing 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17722
EnsembleID ENSG00000198369
Uniprot Q7Z698

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SPRED2 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SPRED2 GO:0005173,GO:0005515,GO:0005829,GO:0005886,GO:0010719,GO:0010801,GO:0019901,GO:0019901,GO:0030291,GO:0030512,GO:0030658,GO:0043409,GO:0043409,GO:0043517,GO:0070373,GO:0090311,GO:1902747

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SPRED2 SQSTM1 19822672 23180781 physical association anti tag coimmunoprecipitation InnateDB
SPRED2 ELAVL1 19322201 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR SPRED2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 SPRED2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 SPRED2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 SPRED2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C SPRED2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SPRED2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 SPRED2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SPRED2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SPRED2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SPRED2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SPRED2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SPRED2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SPRED2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 SPRED2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SPRED2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SPRED2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SPRED2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 SPRED2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SPRED2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 SPRED2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000021D7C8 SPRED2 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000F31F4 SPRED2 20371350 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B59A2 SPRED2 20371350 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000001EB3 SPRED2 25416803 26657862 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000016FD1B SPRED2 25416803 27827315 mrna cleavage,inhibition western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
KIT SPRED2 25361965 interaction type N/A PTMCode2
SPRED2 KIT 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GNG5 SPRED2 25348397 N/A physical interaction ComPPI
TSNAX SPRED2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRTAP2-3 SPRED2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRTAP12-2 SPRED2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VSNL1 SPRED2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MDFI SPRED2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CBL SPRED2 17094949 24234451 25348397 27898060 association coimmunoprecipitation ComPPI,IntAct,OmniPath
KIT SPRED2 12646235 14525934 14981116 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SPRED2 TESK1 25348397 N/A physical interaction ComPPI
SPRED2 ELAVL1 25348397 N/A physical interaction ComPPI
SPRED2 NBR1 25348397 N/A physical interaction ComPPI
SPRED2 SQSTM1 25348397 N/A physical interaction ComPPI
SPRED2 TOP3B 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SPRED2 SPG21 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SPRED2 ZDHHC17 24234451 24705354 25348397 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping ComPPI,IntAct
SPRED2 PDP1 25348397 N/A physical interaction ComPPI
SPRED2 DPP9 25348397 N/A physical interaction ComPPI
SPRED2 PRTFDC1 25348397 N/A physical interaction ComPPI
SPRED2 RPS6KA3 25348397 N/A physical interaction ComPPI
SPRED2 RPS6KA2 25348397 N/A physical interaction ComPPI
SPRED2 STOM 25348397 N/A physical interaction ComPPI
SPRED2 GNAQ 25348397 N/A physical interaction ComPPI
SPRED2 QARS1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPRED2 AQP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPRED2 NCS1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPRED2 ZNF414 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPRED2 ZNF837 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPRED2 RPS6KA6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPRED2 ZNF575 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPRED2 ZNF417 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPRED2 KCNIP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPRED2 RBM48 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPRED2 NDUFB7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPRED2 LCE1C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPRED2 LCE5A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPRED2 KPRP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPRED2 LCE2B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RHOA SPRED2 14525934 15184877 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
KIT SPRED2 12646235 14981116 27898060 stimulant N/A OmniPath
SPRED2 SQSTM1 19822672 27898060 N/A N/A OmniPath

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