Gene Information gene info

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GENE：ITGA2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ITGA2
FullNmae integrin subunit alpha 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6137
EnsembleID ENSG00000164171
Uniprot P17301

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ITGA2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ITGA2 GO:0001540,GO:0001618,GO:0001666,GO:0002687,GO:0005178,GO:0005515,GO:0005518,GO:0005886,GO:0005886,GO:0005925,GO:0005925,GO:0006929,GO:0006971,GO:0007155,GO:0007160,GO:0007160,GO:0007229,GO:0007229,GO:0007565,GO:0007596,GO:0008305,GO:0009410,GO:0009887,GO:0009897,GO:0009986,GO:0009986,GO:0010634,GO:0014075,GO:0014850,GO:0014911,GO:0030879,GO:0031346,GO:0031589,GO:0032967,GO:0033591,GO:0033627,GO:0033627,GO:0034666,GO:0038064,GO:0038065,GO:0043236,GO:0043395,GO:0043589,GO:0043679,GO:0044877,GO:0045178,GO:0045727,GO:0045785,GO:0045987,GO:0046718,GO:0046872,GO:0048041,GO:0048333,GO:0048471,GO:0048661,GO:0050927,GO:0050966,GO:0051971,GO:0060100,GO:0070365,GO:0071107,GO:0071260,GO:0071392,GO:0098609,GO:0098639

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ITGA2 hsa:3673 path:hsa04145 Phagosome - Homo sapiens (human)
ITGA2 hsa:3673 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
ITGA2 hsa:3673 path:hsa04510 Focal adhesion - Homo sapiens (human)
ITGA2 hsa:3673 path:hsa04512 ECM-receptor interaction - Homo sapiens (human)
ITGA2 hsa:3673 path:hsa04611 Platelet activation - Homo sapiens (human)
ITGA2 hsa:3673 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
ITGA2 hsa:3673 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
ITGA2 hsa:3673 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
ITGA2 hsa:3673 path:hsa05200 Pathways in cancer - Homo sapiens (human)
ITGA2 hsa:3673 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
ITGA2 hsa:3673 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
ITGA2 hsa:3673 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
ITGA2 hsa:3673 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)
ITGA2 hsa:3673 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ITGB5 ITGA2 22470492 24309651 26192618 26519775 9295024 9763615 interaction type N/A ACSN
ITGA2 ILK 11112697 25100717 26192618 9456329 interaction type N/A ACSN
ITGB1 ITGA2 26192618 association N/A ACSN
FOS ITGA2 15067049 16393692 16394015 19667062 21385848 22634314 23418787 23430059 26192618 29556339 9064320 interaction type N/A ACSN
RECQL ITGA2 23180781 24932474 physical association anti tag coimmunoprecipitation InnateDB
CTNNB1 ITGA2 23180781 26515729 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ESR1 ITGA2 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 ITGA2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SP1 ITGA2 11238113 11313353 8887648 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
SP3 ITGA2 11238113 8887648 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
FOXP3 ITGA2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ITGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ITGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ITGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ITGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ITGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 ITGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ITGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ITGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 ITGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 ITGA2 11238113 11313353 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ITGA2 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A ITGA2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000065D58 ITGA2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,experimental interaction detection TarBase
URS0000237AF9 ITGA2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000171CD1 ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000008F0CF ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000F0F49 ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003CC709 ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000035CC3E ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000A057E ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001DABC0 ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD02D ITGA2 21572407 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000075A611 ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000195F5B ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000039607D ITGA2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000052EA98 ITGA2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000000E601 ITGA2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C ITGA2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 ITGA2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 ITGA2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 ITGA2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F ITGA2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA ITGA2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 ITGA2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 ITGA2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C ITGA2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 ITGA2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 ITGA2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 ITGA2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 ITGA2 21572407 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000002569A ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001A4ABF ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002ECEE4 ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000209F04 ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000054A671 ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000105D19 ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 ITGA2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000032835F ITGA2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004AF715 ITGA2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000003ABC4 ITGA2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001F373E ITGA2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C1E1 ITGA2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
STK4 ITGA2 22135298 phosphorylation N/A PhosphoSite
ITGA2 COL1A2 25361965 interaction type N/A PTMCode2
COL1A2 ITGA2 25361965 interaction type N/A PTMCode2
ITGA2 MMP1 25361965 interaction type N/A PTMCode2
MMP1 ITGA2 25361965 interaction type N/A PTMCode2
ITGA2 HSPG2 25361965 interaction type N/A PTMCode2
HSPG2 ITGA2 25361965 interaction type N/A PTMCode2
ITGA2 ITGB1 25361965 interaction type N/A PTMCode2
ITGB1 ITGA2 25361965 interaction type N/A PTMCode2
ITGA2 LAMA1 25361965 interaction type N/A PTMCode2
LAMA1 ITGA2 25361965 interaction type N/A PTMCode2
COL1A1 ITGA2 25361965 interaction type N/A PTMCode2
ITGA2 COL1A1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LGALS3 ITGA2 25348397 N/A physical interaction ComPPI
WASL ITGA2 16582881 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
COL1A2 ITGA2 14525934 17485091 2156854 24234451 25348397 N/A experimental interaction detection,biochemical,in vitro ComPPI,HPRD,IntAct
RABIF ITGA2 25348397 N/A physical interaction ComPPI
FABP3 ITGA2 20802519 24234451 25348397 N/A surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
COL8A1 ITGA2 10666376 12482545 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
KDR ITGA2 21596751 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CD9 ITGA2 14525934 25348397 9812906 9813091 N/A experimental interaction detection,in vivo ComPPI,HPRD
FHL2 ITGA2 25348397 N/A coimmunoprecipitation,physical interaction ComPPI
ITGB1 ITGA2 10397731 14681217 21947080 24234451 25348397 association,physical association anti bait coimmunoprecipitation,biophysical,physical interaction,lex-a dimerization assay,in vitro,in vivo ComPPI,IntAct
CIB1 ITGA2 16582881 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PDIA3 ITGA2 17170699 24234451 25348397 disulfide bond anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CFTR ITGA2 25348397 N/A physical interaction ComPPI
AUP1 ITGA2 25348397 N/A two hybrid,physical interaction ComPPI
ITGA2 HSPG2 14525934 15240572 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ITGA2 COL1A1 11359786 11856343 14525934 2156854 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ITGA2 ACTA1 14525934 25348397 27898060 7503723 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ITGA2 LAMA1 14525934 25348397 9688542 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ITGA2 CD46 25348397 N/A physical interaction ComPPI
ITGA2 MMP1 11359774 11359786 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
ITGA2 PSMD4 25348397 N/A physical interaction ComPPI
ITGA2 SHARPIN 21947080 24234451 25348397 association,physical association anti bait coimmunoprecipitation,fluorescence polarization spectroscopy,pull down,physical interaction ComPPI,IntAct
ITGA2 ERGIC1 25348397 N/A physical interaction ComPPI
ITGA2 ALB 15174051 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ITGA2 LGALS8 25348397 N/A physical interaction ComPPI
ITGA2 BTNL8 25348397 N/A physical interaction ComPPI
ITGA2 ZACN 25348397 N/A physical interaction ComPPI
ITGA2 RSRP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ITGA2 TSC22D2 25348397 N/A physical interaction ComPPI
ITGA2 MGAT4C 25348397 N/A physical interaction ComPPI
ITGA2 TMED6 25348397 N/A physical interaction ComPPI
ITGA2 SCGB1D1 25348397 N/A physical interaction ComPPI
ITGA2 SERPINA12 25348397 N/A physical interaction ComPPI
ITGA2 LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATF2 ITGA2 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ITGA2 ITGA2 14525934 14681217 24234451 physical association experimental interaction detection,lex-a dimerization assay HPRD,IntAct
CD47 ITGA2 10397731 24234451 association anti bait coimmunoprecipitation IntAct

Visualization










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