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GENE：KMT2D

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol KMT2D
FullNmae lysine methyltransferase 2D
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7133
EnsembleID ENSG00000167548
Uniprot O14686

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
KMT2D ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
KMT2D autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
KMT2D GO:0000976,GO:0001555,GO:0003677,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0006355,GO:0008284,GO:0031507,GO:0032259,GO:0033148,GO:0042393,GO:0042800,GO:0042800,GO:0042800,GO:0043627,GO:0044666,GO:0044666,GO:0044666,GO:0045944,GO:0045944,GO:0046872,GO:0048477,GO:0140945,GO:0140999,GO:1904837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
KMT2D hsa:8085 path:hsa00310 Lysine degradation - Homo sapiens (human)
KMT2D hsa:8085 path:hsa01100 Metabolic pathways - Homo sapiens (human)
KMT2D hsa:8085 path:hsa04934 Cushing syndrome - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 KMT2D 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 KMT2D 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 KMT2D 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 KMT2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF KMT2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 KMT2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 KMT2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A KMT2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 KMT2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002C0FCB KMT2D 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000021D7C8 KMT2D 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000EED18 KMT2D 21566225 23592263 25416803 26701625 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS00000DDD35 KMT2D 20371350 23622248 25416803 mrna cleavage,inhibition nucleotide sequence identification,clash TarBase
URS0000435A77 KMT2D 20371350 21572407 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS0000512C88 KMT2D 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000070B1D KMT2D 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EC1BE KMT2D 23622248 24398324 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00001012BC KMT2D 23622248 25416803 26701625 mrna cleavage,inhibition clip,clash TarBase
URS00003D5391 KMT2D 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A7F58 KMT2D 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000035CC3E KMT2D 23446348 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS000052E1A6 KMT2D 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000600E6 KMT2D 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD KMT2D 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000041CB9C KMT2D 23622248 25416803 26701625 mrna cleavage,inhibition clip,clash TarBase
URS0000153377 KMT2D 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001B341F KMT2D 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000019907A KMT2D 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000BD6DC KMT2D 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000009EA8F KMT2D 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00006DE17B KMT2D 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00005BB0FD KMT2D 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00001C85C7 KMT2D 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00002E728C KMT2D 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000ECE9C KMT2D 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004E02F2 KMT2D 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000001A7A KMT2D 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D1FC KMT2D 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001C3AC1 KMT2D 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00001F5B39 KMT2D 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002C7B2B KMT2D 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003758F0 KMT2D 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000027464B KMT2D 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001DC1D3 KMT2D 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000077DDE KMT2D 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000C403E KMT2D 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00003D8730 KMT2D 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000A07C1 KMT2D 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 KMT2D 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000032EF64 KMT2D 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000237CBD KMT2D 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 KMT2D 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 KMT2D 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000000B1C9 KMT2D 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D KMT2D 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000000EF0B KMT2D 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003BD367 KMT2D 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001B12A4 KMT2D 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000331800 KMT2D 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000005481D KMT2D 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000170D8B KMT2D 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000134ADC KMT2D 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC4BD KMT2D 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000FC8EB KMT2D 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000011A030 KMT2D 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000458AD2 KMT2D 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000057FDB8 KMT2D 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000535FDD KMT2D 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 KMT2D 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002CEB74 KMT2D 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000041E780 KMT2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000272A92 KMT2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001C770D KMT2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000171CD1 KMT2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000040EE1D KMT2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000022AAA KMT2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000AF45F KMT2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000192A75 KMT2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002394F5 KMT2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000F0F49 KMT2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005F1B8C KMT2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000004BACE KMT2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000025EABA KMT2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000007D64A KMT2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000072B4C8 KMT2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075CC78 KMT2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D814 KMT2D 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001DA458 KMT2D 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK2 KMT2D 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
GOLGA2 KMT2D 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SNW1 KMT2D 20467437 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
DPY30 KMT2D 17178841 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
E2F6 KMT2D 25348397 N/A physical interaction ComPPI
SMAD1 KMT2D 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
AR KMT2D 22722839 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PAXIP1 KMT2D 17178841 17500065 17925232 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SMAD9 KMT2D 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KMT2D ESR1 14525934 16603732 24234451 25348397 association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
KMT2D ASH2L 12482968 14525934 16603732 17178841 17925232 24234451 25348397 colocalization,association anti bait coimmunoprecipitation,experimental interaction detection,molecular sieving,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
KMT2D MEN1 14525934 14992727 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
KMT2D CXXC1 25348397 N/A physical interaction ComPPI
KMT2D KDM6A 17178841 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KMT2D CTNNB1 25348397 N/A physical interaction ComPPI
KMT2D E2F5 25348397 N/A physical interaction ComPPI
KMT2D E2F3 25348397 N/A physical interaction ComPPI
KMT2D E2F2 25348397 N/A physical interaction ComPPI
KMT2D POLR2A 25348397 N/A physical interaction ComPPI
KMT2D RBBP5 16603732 17178841 17500065 17925232 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KMT2D MEF2D 25348397 N/A physical interaction ComPPI
KMT2D WDR82 25348397 N/A physical interaction ComPPI
KMT2D PYGO2 25348397 N/A physical interaction ComPPI
KMT2D KDM4B 25348397 N/A physical interaction ComPPI
KMT2D H3C15 25348397 N/A physical interaction ComPPI
KMT2D MAX 25348397 N/A physical interaction ComPPI
KMT2D SENP3 25348397 N/A physical interaction ComPPI
KMT2D UBAC2 25348397 N/A physical interaction ComPPI
KMT2D HERC2 25348397 N/A physical interaction ComPPI
KMT2D HERC2P3 25348397 N/A physical interaction ComPPI
KMT2D PPP1R21 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KMT2D RBM45 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KMT2D FOXK2 25348397 N/A physical interaction ComPPI
KMT2D EYA2 25348397 N/A physical interaction ComPPI
KMT2D NR3C1 25348397 N/A physical interaction ComPPI
KMT2D AKT1 25348397 N/A physical interaction ComPPI
KMT2D WDR5B 16603732 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
KMT2D MATR3 17178841 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
KMT2D PAGR1 17178841 17500065 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
KMT2D NCOA6 12482968 17178841 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
KMT2D TOPBP1 17913746 24234451 25348397 physical association two hybrid ComPPI,IntAct
SRRM1 KMT2D 25348397 N/A physical interaction ComPPI
EEF1B2 KMT2D 25348397 N/A physical interaction ComPPI
WDR5 KMT2D 15960975 17178841 17500065 24234451 25348397 27705803 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,tandem affinity purification ComPPI,IntAct
MKI67 KMT2D 24234451 26949251 association anti tag coimmunoprecipitation IntAct
MANF KMT2D 24234451 30021884 physical association cross-linking study IntAct
SEPTIN7 KMT2D 24234451 30021884 physical association cross-linking study IntAct
KMT2D ESR1 16603732 21502505 27898060 stimulant N/A OmniPath
PAX7 KMT2D 22863532 27898060 stimulant N/A OmniPath

Visualization










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