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GENE：LEF1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LEF1
FullNmae lymphoid enhancer binding factor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6551
EnsembleID ENSG00000138795
Uniprot Q9UJU2

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LEF1 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LEF1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LEF1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LEF1 GO:0000122,GO:0000977,GO:0000978,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001222,GO:0001227,GO:0001228,GO:0001569,GO:0001649,GO:0001756,GO:0001837,GO:0002040,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006357,GO:0006366,GO:0008013,GO:0008013,GO:0008013,GO:0008301,GO:0010628,GO:0010718,GO:0021542,GO:0021861,GO:0021873,GO:0021943,GO:0030177,GO:0030223,GO:0030326,GO:0030331,GO:0030335,GO:0030509,GO:0030854,GO:0030854,GO:0030879,GO:0032696,GO:0032713,GO:0032714,GO:0032993,GO:0033153,GO:0042100,GO:0042393,GO:0042475,GO:0042826,GO:0043066,GO:0043392,GO:0043565,GO:0043586,GO:0043923,GO:0045063,GO:0045295,GO:0045588,GO:0045597,GO:0045843,GO:0045892,GO:0045892,GO:0045893,GO:0045893,GO:0045944,GO:0045944,GO:0045944,GO:0048341,GO:0050767,GO:0050909,GO:0060033,GO:0060070,GO:0060070,GO:0060325,GO:0060326,GO:0060710,GO:0061153,GO:0062009,GO:0070016,GO:0070742,GO:0071168,GO:0071345,GO:0071353,GO:0071864,GO:0071866,GO:0140416,GO:1902262,GO:1902732,GO:1904019,GO:1990837,GO:1990907,GO:1990907

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LEF1 hsa:51176 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
LEF1 hsa:51176 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
LEF1 hsa:51176 path:hsa04520 Adherens junction - Homo sapiens (human)
LEF1 hsa:51176 path:hsa04916 Melanogenesis - Homo sapiens (human)
LEF1 hsa:51176 path:hsa04934 Cushing syndrome - Homo sapiens (human)
LEF1 hsa:51176 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
LEF1 hsa:51176 path:hsa05132 Salmonella infection - Homo sapiens (human)
LEF1 hsa:51176 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
LEF1 hsa:51176 path:hsa05200 Pathways in cancer - Homo sapiens (human)
LEF1 hsa:51176 path:hsa05210 Colorectal cancer - Homo sapiens (human)
LEF1 hsa:51176 path:hsa05213 Endometrial cancer - Homo sapiens (human)
LEF1 hsa:51176 path:hsa05215 Prostate cancer - Homo sapiens (human)
LEF1 hsa:51176 path:hsa05216 Thyroid cancer - Homo sapiens (human)
LEF1 hsa:51176 path:hsa05217 Basal cell carcinoma - Homo sapiens (human)
LEF1 hsa:51176 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)
LEF1 hsa:51176 path:hsa05224 Breast cancer - Homo sapiens (human)
LEF1 hsa:51176 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
LEF1 hsa:51176 path:hsa05226 Gastric cancer - Homo sapiens (human)
LEF1 hsa:51176 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BRD7 LEF1 17666529 21358755 22290435 22761862 26192618 interaction type N/A ACSN
CTNNB1 LEF1 10890911 12077367 14638683 15684397 15728254 16510874 16510875 21071413 23180781 23331499 8757136 9419974 stimulation,physical association anti tag coimmunoprecipitation,pull down InnateDB,SignaLink,SignaLink
LEF1 POU3F2 15024079 23180781 physical association anti tag coimmunoprecipitation InnateDB
LEF1 MITF 12032083 12048204 15024079 23180781 physical association anti tag coimmunoprecipitation,pull down,electrophoretic mobility shift assay InnateDB
SMAD7 LEF1 15684397 23180781 physical association anti tag coimmunoprecipitation InnateDB
LEF1 PITX2 15728254 23180781 physical association pull down InnateDB
LEF1 EGR1 20690147 23180781 physical association anti tag coimmunoprecipitation InnateDB
LEF1 APC 15525529 23180781 physical association pull down InnateDB
LEF1 DCT 12032083 23180781 physical association electrophoretic mobility shift assay InnateDB
LEF1 CTNNAL1 22359570 23180781 physical association electrophoretic mobility supershift assay InnateDB
BCL2 LEF1 21795403 23180781 physical association anti tag coimmunoprecipitation InnateDB
LEF1 BIRC5 21795403 23180781 physical association anti tag coimmunoprecipitation InnateDB
LEF1 MYB 21795403 23180781 physical association anti tag coimmunoprecipitation InnateDB
EPHB4 LEF1 23180781 25724901 physical association anti tag coimmunoprecipitation InnateDB
LEF1 LEF1 19653274 19850024 26467481 up-regulates quantity by expression,transcriptional regulation N/A Signor
SMAD4 LEF1 10890911 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
SMAD3 LEF1 10890911 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
SMAD2 LEF1 10890911 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
NOTCH1 LEF1 11604490 18988627 23331499 stimulation N/A SignaLink,SignaLink
LEF1 TLE1 23331499 9751710 stimulation N/A SignaLink
NLK LEF1 12556497 12901858 19623618 23331499 stimulation N/A SignaLink
CSNK2A1 LEF1 19623618 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR LEF1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 LEF1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 LEF1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 LEF1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 LEF1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 LEF1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 LEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 LEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 LEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 LEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 LEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS LEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF LEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 LEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 LEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 LEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 LEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TLE5 LEF1 20676368 trascriptional regulation,stimulation inferred by curator TFlink
LMO2 LEF1 22517897 trascriptional regulation,stimulation inferred by curator TFlink
PAX5 LEF1 9545244 trascriptional regulation,stimulation inferred by curator TFlink
PITX2 LEF1 17785445 trascriptional regulation,stimulation inferred by curator TFlink
ZBTB16 LEF1 19723763 trascriptional regulation,stimulation inferred by curator TFlink
LEF1 LEF1 N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD3 LEF1 N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD7 LEF1 N/A trascriptional regulation,stimulation inferred by curator TFlink
SP1 LEF1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 LEF1 21566225 rna interference,inhibition experimental interaction detection miRSponge
URS00000AA464 LEF1 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EED18 LEF1 21566225 25416803 25587085 28098757 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001F5B39 LEF1 22769578 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002C7B2B LEF1 22421157 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000101787 LEF1 23695168 25416803 mrna cleavage,inhibition experimental interaction detection,western blot TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 LEF1 22135298 phosphorylation N/A PhosphoSite
NLK LEF1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
SMAD4 LEF1 10890911 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
NLK LEF1 12556497 12901858 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TLE1 LEF1 14525934 24234451 25348397 9751710 N/A experimental interaction detection,far western blotting,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 LEF1 10890911 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SMAD7 LEF1 25348397 N/A physical interaction ComPPI
NOTCH1 LEF1 11604490 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
NFATC1 LEF1 25348397 N/A physical interaction ComPPI
RB1 LEF1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD2 LEF1 10890911 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
VDR LEF1 17517646 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EP300 LEF1 12446687 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SMAD3 LEF1 10890911 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
JUP LEF1 14661054 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UBTF LEF1 12748295 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TCF7L2 LEF1 25348397 N/A physical interaction ComPPI
RUVBL1 LEF1 25348397 N/A physical interaction ComPPI
BUB1 LEF1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
E2F1 LEF1 25348397 N/A physical interaction ComPPI
STAT5A LEF1 25348397 N/A physical interaction ComPPI
NFATC2 LEF1 25348397 N/A physical interaction ComPPI
CTNNB1 LEF1 12556497 14525934 15684397 17510365 17517646 18077326 20123964 21743491 24234451 25348397 8757136 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,tandem affinity purification ComPPI,HPRD,IntAct
STK11 LEF1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
AURKA LEF1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
PIAS4 LEF1 11731474 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
RNF14 LEF1 25348397 N/A physical interaction ComPPI
TLE2 LEF1 25348397 N/A physical interaction ComPPI
BAX LEF1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
FHIT LEF1 18077326 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
PITX2 LEF1 14525934 15728254 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
MLH1 LEF1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
DPYSL2 LEF1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DAZAP2 LEF1 25348397 N/A physical interaction ComPPI
ALYREF LEF1 14525934 25348397 27898060 9119228 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
EGR1 LEF1 21743491 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
IGF1R LEF1 22261717 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
NRAS LEF1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
KMT5A LEF1 25348397 N/A physical interaction ComPPI
CDX1 LEF1 14525934 15143193 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
MSH2 LEF1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
RNF138 LEF1 25348397 N/A physical interaction ComPPI
HINT1 LEF1 25348397 N/A physical interaction ComPPI
PRMT6 LEF1 25348397 N/A physical interaction ComPPI
NARF LEF1 25348397 N/A physical interaction ComPPI
ZBTB3 LEF1 25348397 N/A physical interaction ComPPI
LEF1 MITF 12032083 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
LEF1 DACT1 25348397 N/A physical interaction ComPPI
LEF1 HDAC1 25348397 N/A physical interaction ComPPI
LEF1 MYB 25348397 N/A physical interaction ComPPI
LEF1 TCF4 21743491 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
LEF1 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
LEF1 MLLT11 24234451 25348397 26079538 physical association two hybrid ComPPI,IntAct
LEF1 SUMO2 11731474 14525934 N/A experimental interaction detection HPRD
LEF1 RUNX2 12551949 14525934 N/A experimental interaction detection HPRD
KPNA2 LEF1 14525934 8631802 N/A experimental interaction detection,two hybrid HPRD
KPNA1 LEF1 14525934 8631802 N/A experimental interaction detection,two hybrid HPRD
ALX4 LEF1 11696550 14525934 27898060 N/A experimental interaction detection HPRD,OmniPath
CTNNB1 LEF1 10890911 10958684 11751639 11835406 12077367 12556497 12748295 15525529 15684397 15728254 15735151 15768032 16204248 16309666 16510874 16510875 17143293 17445771 17517646 18077326 18202148 18296023 20123964 21078818 21743491 23151663 24748645 27898060 8757136 8892228 9065403 9419974 stimulant N/A OmniPath
CSNK1A1 LEF1 15747065 27898060 inhibition,stimulant N/A OmniPath
LEF1 MITF 12032083 12048204 27898060 stimulant N/A OmniPath
CSNK1E LEF1 15747065 27898060 inhibition N/A OmniPath
TCF7 LEF1 12032083 27898060 stimulant N/A OmniPath
CSNK1D LEF1 15747065 27898060 inhibition N/A OmniPath
SMAD2 LEF1 10890911 15750622 27898060 stimulant N/A OmniPath
NOTCH1 LEF1 11604490 27898060 stimulant N/A OmniPath
CSNK2A1 LEF1 15747065 17113388 19623618 27898060 2861485 stimulant N/A OmniPath
SMAD4 LEF1 10890911 27898060 stimulant N/A OmniPath
NLK LEF1 12482967 12556497 12901858 19623618 20194509 22373574 24394665 27898060 inhibition,stimulant N/A OmniPath
PAX3 LEF1 15729346 20006729 27898060 stimulant N/A OmniPath
SMAD3 LEF1 10890911 15750622 27898060 stimulant N/A OmniPath
LEF1 TLE1 15768032 27898060 9751710 stimulant N/A OmniPath
LEF1 PITX2 15728254 19850024 27898060 stimulant N/A OmniPath
TLE2 LEF1 19460168 27898060 inhibition N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009C118F LEF1 27087310 direct interaction,inhibition N/A NPInter

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