Gene Information gene info

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GENE：THOC1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol THOC1
FullNmae THO complex subunit 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:19070
EnsembleID ENSG00000079134
Uniprot Q96FV9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
THOC1 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
THOC1 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
THOC1 GO:0000018,GO:0000346,GO:0000347,GO:0000445,GO:0000445,GO:0000781,GO:0003677,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0006396,GO:0006397,GO:0006406,GO:0006406,GO:0006406,GO:0006915,GO:0007165,GO:0008380,GO:0016363,GO:0016607,GO:0031297,GO:0032784,GO:0032784,GO:0032786,GO:0046784,GO:0048297,GO:2000002

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
THOC1 hsa:9984 path:hsa03013 Nucleocytoplasmic transport - Homo sapiens (human)
THOC1 hsa:9984 path:hsa03040 Spliceosome - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR THOC1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA THOC1 17242690 18971253 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
ETS1 THOC1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 THOC1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 THOC1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 THOC1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 THOC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF THOC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 THOC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 THOC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 THOC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 THOC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS THOC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A THOC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 THOC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000021D7C8 THOC1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
EXOC5 THOC1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SNW1 THOC1 20467437 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PCBD1 THOC1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
MOAP1 THOC1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RB1 THOC1 14525934 25348397 27898060 7525595 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
DHX9 THOC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SF3B1 THOC1 25348397 N/A physical interaction ComPPI
PRMT1 THOC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPA1 THOC1 25348397 N/A physical interaction ComPPI
DSCC1 THOC1 25348397 N/A physical interaction ComPPI
THOC5 THOC1 19059247 19165146 22365833 23299939 24234451 25348397 26496610 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction,fluorescence microscopy ComPPI,IntAct
TPM3 THOC1 25348397 N/A physical interaction ComPPI
PDHA1 THOC1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RABGEF1 THOC1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UTRN THOC1 25348397 N/A physical interaction ComPPI
BCCIP THOC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPA2 THOC1 25348397 N/A physical interaction ComPPI
RPA3 THOC1 25348397 N/A physical interaction ComPPI
THOC1 DDX39B 11979277 23299939 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
THOC1 ALYREF 19165146 23299939 24234451 25348397 26496610 colocalization,association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct
THOC1 THOC2 19165146 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 NCBP1 25348397 N/A physical interaction ComPPI
THOC1 THOC6 19165146 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 SF3B2 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
THOC1 ZCCHC8 25348397 N/A physical interaction ComPPI
THOC1 ZC3H15 25348397 N/A physical interaction ComPPI
THOC1 TPM1 25348397 N/A physical interaction ComPPI
THOC1 USP13 25348397 N/A physical interaction ComPPI
THOC1 DHX8 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
THOC1 WDR77 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
THOC1 TRIM54 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
THOC1 USHBP1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
THOC1 OBSL1 25348397 N/A physical interaction ComPPI
THOC1 RNF2 25348397 N/A physical interaction ComPPI
THOC1 ADAR 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 FMR1 25348397 N/A physical interaction ComPPI
THOC1 GSN 25348397 N/A physical interaction ComPPI
THOC1 SP110 25348397 N/A physical interaction ComPPI
THOC1 NFKBIL1 25348397 N/A physical interaction ComPPI
THOC1 FXR1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 TOP3B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 BCLAF1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 ZC3H11A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 THRAP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 NCBP3 24234451 25348397 26382858 26496610 association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
THOC1 DDX39A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 ZC3H13 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 ZC3H3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 CHTOP 23299939 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 RBM15B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 GTSE1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 RBM27 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 CAAP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 FYTTD1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 POLDIP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 ATG4A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
THOC1 NEDD4 25348397 N/A physical interaction ComPPI
THOC1 MRPL12 25348397 N/A physical interaction ComPPI
THOC1 SLC25A10 25348397 N/A physical interaction ComPPI
THOC1 MTNR1B 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
THOC1 DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
THOC1 VHL 25348397 N/A two hybrid ComPPI
THOC1 NXF1 23299939 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
THOC1 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
THOC1 TRIM27 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
THOC1 PAX6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
THOC1 PPP1R12C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
XPO4 THOC1 25348397 N/A physical interaction ComPPI
EIF4A3 THOC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SARNP THOC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IK THOC1 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MKI67 THOC1 24234451 26949251 association anti tag coimmunoprecipitation IntAct

Visualization










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