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GENE：LTA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LTA
FullNmae lymphotoxin alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6709
EnsembleID ENSG00000226979
Uniprot P01374

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LTA autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LTA GO:0001666,GO:0002876,GO:0002925,GO:0005102,GO:0005125,GO:0005164,GO:0005515,GO:0005615,GO:0005886,GO:0006915,GO:0006959,GO:0007165,GO:0007267,GO:0007584,GO:0009410,GO:0032496,GO:0032729,GO:0043065,GO:0048147,GO:0048535,GO:0050830,GO:0060252

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LTA hsa:4049 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
LTA hsa:4049 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
LTA hsa:4049 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
LTA hsa:4049 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
LTA hsa:4049 path:hsa04940 Type I diabetes mellitus - Homo sapiens (human)
LTA hsa:4049 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
LTA hsa:4049 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL2 LTA 10807786 11280761 11460167 14660645 15289500 15563472 17301840 1825141 18264787 18758473 19528259 21133840 21232017 22224781 23650441 24699077 24958845 26192618 26755705 2965306 6164929 9625766 interaction type N/A ACSN
TNFRSF14 LTA 11164894 23180781 physical association solid phase assay InnateDB
LTB LTA 23180781 8171323 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF1A LTA 23180781 8171323 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GATA1 LTA 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 LTA 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 LTA 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 LTA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 LTA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS LTA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MSC LTA 15052269 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 LTA N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 LTA 25416803 28097098 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
TNFRSF14 LTA 25361965 interaction type N/A PTMCode2
LTA TNFRSF14 25361965 interaction type N/A PTMCode2
TNFRSF1A LTA 25361965 interaction type N/A PTMCode2
LTA TNFRSF1A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ANKRD40 LTA 25348397 N/A physical interaction ComPPI
TUBA1B LTA 25348397 N/A physical interaction ComPPI
TNFRSF1A LTA 14525934 25348397 8387891 N/A experimental interaction detection,x-ray crystallography,physical interaction,biochemical,in vivo ComPPI,HPRD
TUBA4A LTA 14525934 15129282 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TNF LTA 25348397 N/A coimmunoprecipitation,physical interaction ComPPI
TUBA1A LTA 15129282 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
LGALS2 LTA 14525934 15129282 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,t7 phage display,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RIPK1 LTA 23815148 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TNFRSF1B LTA 14525934 2160731 25348397 8123048 9552007 N/A cross-linking study,experimental interaction detection,physical interaction,biochemical,in vivo ComPPI,HPRD
ABHD16A LTA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIRC2 LTA 23815148 24234451 25348397 association tandem affinity purification ComPPI,IntAct
LTBR LTA 14525934 25348397 8171323 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
LTB LTA 14525934 25348397 27898060 7916655 7995952 8171323 8621492 9235946 9317127 N/A affinity chromatography technology,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
TNFRSF14 LTA 14525934 24234451 25348397 9153189 9462508 physical association experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
CLSPN LTA 25348397 N/A physical interaction ComPPI
UMOD LTA 14525934 25348397 27898060 8323280 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
LTA SLC30A2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LTA LTA 11164894 14525934 23815148 24234451 9235946 N/A experimental interaction detection,blue native page HPRD,IntAct
LTA LTBR 27898060 7995952 8171323 stimulant N/A OmniPath
LTA TNFRSF1A 12387745 1310388 2170974 27898060 8171323 8182064 8288897 8387891 stimulant N/A OmniPath
TNFRSF1A LTA 1310388 2170974 27898060 8171323 8182064 8288897 8387891 N/A N/A OmniPath

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