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GENE：NCF2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NCF2
FullNmae neutrophil cytosolic factor 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7661
EnsembleID ENSG00000116701
Uniprot P19878

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NCF2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NCF2 GO:0001669,GO:0005515,GO:0005829,GO:0005829,GO:0005886,GO:0006801,GO:0006909,GO:0006968,GO:0009055,GO:0016020,GO:0016175,GO:0016176,GO:0016176,GO:0022900,GO:0031267,GO:0032010,GO:0042554,GO:0042554,GO:0042554,GO:0043020,GO:0043020,GO:0043020,GO:0045087,GO:0045730,GO:0045730

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NCF2 hsa:4688 path:hsa04145 Phagosome - Homo sapiens (human)
NCF2 hsa:4688 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
NCF2 hsa:4688 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
NCF2 hsa:4688 path:hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
NCF2 hsa:4688 path:hsa05020 Prion disease - Homo sapiens (human)
NCF2 hsa:4688 path:hsa05140 Leishmaniasis - Homo sapiens (human)
NCF2 hsa:4688 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
NCF2 hsa:4688 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)
NCF2 hsa:4688 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)
NCF2 hsa:4688 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CYBA NCF2 10679059 10714681 11062502 11146654 11385609 11747822 11907067 12626562 12740575 14697347 15169870 15184873 15536084 15927447 17517963 18423981 18809714 19372727 19380816 19732719 21178402 21383238 22157818 22827577 26192618 27331412 interaction type N/A ACSN
CYBB NCF2 10679059 10714681 11062502 11146654 11385609 11747822 11907067 12626562 12740575 14697347 15169870 15184873 15536084 15927447 17517963 18423981 18809714 19372727 19380816 19732719 21178402 21383238 22157818 22827577 26192618 27331412 interaction type N/A ACSN
NCF1 NCF2 10679059 10714681 11062502 11146654 11385609 11747822 11907067 12626562 12740575 14697347 15169870 15184873 15536084 15927447 17517963 18423981 18809714 19372727 19380816 19732719 21178402 21383238 22157818 22827577 23180781 26192618 27331412 8760383 interaction type,physical association pull down ACSN,InnateDB
NCF4 NCF2 12813044 23180781 8760383 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
IRF1 NCF2 10570299 23180781 physical association electrophoretic mobility shift assay InnateDB
IRF8 NCF2 10570299 15371411 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
CREBBP NCF2 10570299 23180781 physical association electrophoretic mobility supershift assay InnateDB
NCF2 PLA2G4A 12913107 23180781 physical association anti tag coimmunoprecipitation InnateDB
PLA2G4A NCF2 12913107 23180781 physical association anti tag coimmunoprecipitation InnateDB
S100A8 NCF2 15642721 23180781 physical association pull down InnateDB
S100A9 NCF2 15642721 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 NCF2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 NCF2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 NCF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NCF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 NCF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NCF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF NCF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 NCF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
IRF1 NCF2 10570299 trascriptional regulation,stimulation inferred by curator TFlink
IRF8 NCF2 10570299 trascriptional regulation,stimulation inferred by curator TFlink
MED15 NCF2 20025940 trascriptional regulation,stimulation inferred by curator TFlink
PLAGL2 NCF2 17462995 20025940 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NCF2 10570299 20025940 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
MAPK1 NCF2 22135298 phosphorylation N/A PhosphoSite
RAC2 NCF2 25361965 interaction type N/A PTMCode2
NCF2 RAC2 25361965 interaction type N/A PTMCode2
NCF4 NCF2 25361965 interaction type N/A PTMCode2
NCF2 NCF4 25361965 interaction type N/A PTMCode2
CYBA NCF2 25361965 interaction type N/A PTMCode2
NCF2 CYBA 25361965 interaction type N/A PTMCode2
NCF2 S100A8 25361965 interaction type N/A PTMCode2
S100A8 NCF2 25361965 interaction type N/A PTMCode2
NCF2 CYBB 25361965 interaction type N/A PTMCode2
CYBB NCF2 25361965 interaction type N/A PTMCode2
RAC1 NCF2 25361965 interaction type N/A PTMCode2
NCF2 RAC1 25361965 interaction type N/A PTMCode2
NCF1 NCF2 25361965 interaction type N/A PTMCode2
NCF2 NCF1 25361965 interaction type N/A PTMCode2
CDC42 NCF2 25361965 interaction type N/A PTMCode2
NCF2 CDC42 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GNAI3 NCF2 25348397 N/A physical interaction ComPPI
GOLGA2 NCF2 24234451 25348397 25416956 25910212 26871637 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
HSPA8 NCF2 24234451 25348397 25910212 association anti tag coimmunoprecipitation ComPPI,IntAct
CDC42 NCF2 11090627 14525934 24234451 25348397 7738010 9642115 physical association two hybrid,experimental interaction detection,filter binding,isothermal titration calorimetry,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
RAC1 NCF2 11090627 11896062 14525934 24234451 25348397 25416956 7738010 8036496 9255350 9624165 physical association two hybrid,experimental interaction detection,isothermal titration calorimetry,x-ray crystallography,physical interaction,mammalian protein protein interaction trap,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
HSP90AB1 NCF2 24234451 25348397 25910212 association anti tag coimmunoprecipitation ComPPI,IntAct
DDIT4L NCF2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKCD NCF2 15591124 24234451 25348397 27898060 phosphorylation reaction,physical association anti bait coimmunoprecipitation,protein kinase assay ComPPI,IntAct,OmniPath
PRKDC NCF2 25348397 N/A physical interaction ComPPI
KIFAP3 NCF2 21516116 24234451 25348397 25416956 25910212 26871637 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
NCF1 NCF2 12169629 15657040 16297854 16782902 19129478 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,classical fluorescence spectroscopy,two hybrid,nuclear magnetic resonance,pull down,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach ComPPI,IntAct
NCF4 NCF2 10486263 10672014 11483497 11796733 11893732 12813044 12887891 14525934 16297854 16782902 24234451 25348397 association,physical association affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,filter binding,x-ray crystallography,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PLA2G4A NCF2 25348397 N/A physical interaction ComPPI
CYBA NCF2 11248021 11893732 11917128 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TRAF4 NCF2 25348397 N/A physical interaction ComPPI
SYTL1 NCF2 25348397 N/A physical interaction,in vitro ComPPI
NCF2 RAC2 11090627 14525934 24234451 25348397 9624165 9642115 physical association experimental interaction detection,isothermal titration calorimetry,physical interaction,in vivo ComPPI,HPRD,IntAct
NCF2 PRDX6 12121978 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
NCF2 S100A8 14525934 15642721 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NCF2 CYBB 11248021 11893732 11917128 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NCF2 NCF1B 25348397 N/A physical interaction ComPPI
NCF2 GNAI1 25348397 N/A physical interaction ComPPI
NCF2 GNAI2 16782902 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCF2 GNB1 16782902 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCF2 S100A9 25348397 N/A physical interaction ComPPI
NCF2 CAMSAP3 25348397 N/A physical interaction ComPPI
NCF2 BPGM 25348397 N/A physical interaction ComPPI
NCF2 TARDBP 25348397 N/A physical interaction ComPPI
NCF2 USP47 25348397 N/A physical interaction ComPPI
NCF2 TBC1D4 25348397 N/A physical interaction ComPPI
DDX21 NCF2 24234451 30021884 physical association cross-linking study IntAct
MAPK1 NCF2 27898060 9931304 N/A N/A OmniPath
NCF1 NCF2 10486263 11248021 11733522 11796733 11893732 12169629 15657040 16052631 16297854 16782902 19129478 27898060 7938008 8676437 8760383 9121467 N/A N/A OmniPath

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