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GENE：NME2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NME2
FullNmae NME/NM23 nucleoside diphosphate kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7850
EnsembleID ENSG00000243678
Uniprot P22392

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NME2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NME2 GO:0001726,GO:0003677,GO:0003713,GO:0004550,GO:0004550,GO:0004673,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0006183,GO:0006228,GO:0006241,GO:0007155,GO:0007229,GO:0009142,GO:0016310,GO:0019003,GO:0030027,GO:0034774,GO:0042981,GO:0043066,GO:0045618,GO:0045682,GO:0045893,GO:0045893,GO:0045944,GO:0046872,GO:0048471,GO:0050679,GO:0051880,GO:0070062,GO:0071944,GO:1904813

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NME2 hsa:4831 path:hsa00230 Purine metabolism - Homo sapiens (human)
NME2 hsa:4831 path:hsa00240 Pyrimidine metabolism - Homo sapiens (human)
NME2 hsa:4831 path:hsa00983 Drug metabolism - other enzymes - Homo sapiens (human)
NME2 hsa:4831 path:hsa01100 Metabolic pathways - Homo sapiens (human)
NME2 hsa:4831 path:hsa01232 Nucleotide metabolism - Homo sapiens (human)
NME2 hsa:4831 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR NME2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 NME2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC NME2 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
SMARCA4 NME2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NME2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 NME2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 NME2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NME2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A NME2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NME2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF NME2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NME2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 NME2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYB NME2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002FF522 NME2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 NME2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001F0C23 NME2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000170CF4 NME2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F4AC3 NME2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001B341F NME2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004AAAFF NME2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000023F008 NME2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 NME2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 NME2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB0E NME2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005586D0 NME2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000032835F NME2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 NME2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000058878F NME2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001C0099 NME2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000021202F NME2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075CC78 NME2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075D814 NME2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001012BC NME2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003AD2AA NME2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 NME2 22135298 phosphorylation N/A PhosphoSite
NME2 KCNN4 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PIN1 NME2 25348397 N/A physical interaction ComPPI
NME3 NME2 11042679 14525934 16169070 24234451 25348397 physical association experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vivo ComPPI,HPRD,IntAct
LDHB NME2 25348397 N/A physical interaction ComPPI
LDHA NME2 25348397 N/A physical interaction ComPPI
VIM NME2 11082283 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
PCBP1 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CFL1 NME2 25348397 N/A physical interaction ComPPI
PPP2R1A NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
KIF5B NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
LSM2 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SET NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
VCP NME2 25348397 N/A physical interaction ComPPI
FKBP1A NME2 25348397 N/A physical interaction ComPPI
H2BC4 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MCM2 NME2 25348397 N/A physical interaction ComPPI
HTR1B NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DSTN NME2 25348397 N/A physical interaction ComPPI
PPP1R8 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CTBP1 NME2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RHOB NME2 19637314 24234451 25348397 physical association two hybrid ComPPI,IntAct
HERC5 NME2 14525934 18535780 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
YWHAZ NME2 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
PDIA6 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
UBE2N NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ENO1 NME2 25348397 N/A physical interaction ComPPI
DNM1 NME2 11872741 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
STIP1 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPT NME2 25348397 N/A physical interaction ComPPI
NME1 NME2 17314099 21988832 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
ST13 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CACYBP NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TAGLN NME2 25348397 N/A physical interaction ComPPI
PPP2CA NME2 14525934 17163575 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
AKR1B1 NME2 25348397 N/A physical interaction ComPPI
ITGB1BP1 NME2 25348397 N/A two hybrid ComPPI
RAB5A NME2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RPS6 NME2 24234451 25348397 29568061 association pull down ComPPI,IntAct
RAD23A NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
FKBP1B NME2 25348397 N/A physical interaction ComPPI
MDM2 NME2 21504894 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TUBA1A NME2 24234451 25348397 27291054 association pull down ComPPI,IntAct
FKBP2 NME2 25348397 N/A physical interaction ComPPI
STRAP NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RTN4 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NOS2 NME2 25348397 N/A physical interaction ComPPI
UBE2K NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
WWOX NME2 25348397 N/A physical interaction ComPPI
FDPS NME2 25348397 N/A physical interaction ComPPI
GIT2 NME2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKN NME2 25348397 N/A physical interaction ComPPI
SSB NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
FGB NME2 25348397 N/A physical interaction ComPPI
SVIL NME2 14525934 20309963 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
DYNC1H1 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
WDR1 NME2 25348397 N/A physical interaction ComPPI
CCNG2 NME2 25348397 N/A physical interaction ComPPI
RORA NME2 14525934 25348397 8858107 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
BNIPL NME2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TERF1 NME2 14525934 25348397 9480811 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
NPC2 NME2 25348397 N/A physical interaction ComPPI
ESR1 NME2 25348397 N/A physical interaction ComPPI
CFL2 NME2 25348397 N/A physical interaction ComPPI
PAFAH1B2 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMB4 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TALDO1 NME2 25348397 N/A physical interaction ComPPI
PSMA7 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SOD1 NME2 25348397 N/A physical interaction ComPPI
DIS3 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UBE2V1 NME2 25348397 N/A physical interaction ComPPI
MOB4 NME2 11872741 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
OAT NME2 25348397 N/A physical interaction ComPPI
MAGOH NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RORB NME2 25348397 N/A two hybrid,in vitro ComPPI
PPIF NME2 25348397 N/A physical interaction ComPPI
HSF1 NME2 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RUVBL2 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF3M NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
POLR2H NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PGRMC1 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
AK2 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK20 NME2 23602568 24234451 25348397 association tandem affinity purification ComPPI,IntAct
ADSS2 NME2 25348397 N/A physical interaction ComPPI
ACLY NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NME2 PPP1R7 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NME2 EPPK1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NME2 H2BC11 25348397 N/A physical interaction ComPPI
NME2 LYZ 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NME2 PSMA2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NME2 RPL38 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NME2 HERC3 25348397 N/A physical interaction ComPPI
NME2 HERC6 25348397 N/A physical interaction ComPPI
NME2 RPS3 25348397 N/A physical interaction ComPPI
NME2 TBXA2R 14525934 14976202 25348397 27898060 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
NME2 IDH1 25348397 N/A physical interaction ComPPI
NME2 TRABD 25348397 N/A physical interaction ComPPI
NME2 AKR1A1 25348397 N/A physical interaction ComPPI
NME2 AKR1B15 25348397 N/A physical interaction ComPPI
NME2 ENO2 25348397 N/A physical interaction ComPPI
NME2 ENO3 25348397 N/A physical interaction ComPPI
NME2 GOT1 25348397 N/A physical interaction ComPPI
NME2 LDHC 25348397 N/A physical interaction ComPPI
NME2 SNX3 25348397 N/A physical interaction ComPPI
NME2 HIBCH 25348397 N/A physical interaction ComPPI
NME2 PRDX5 25348397 N/A physical interaction ComPPI
NME2 SNX12 25348397 N/A physical interaction ComPPI
NME2 TAGLN2 25348397 N/A physical interaction ComPPI
NME2 TAGLN3 25348397 N/A physical interaction ComPPI
NME2 PEDS1 25348397 N/A physical interaction ComPPI
NME2 PPM1K 25348397 N/A physical interaction ComPPI
NME2 HYPK 25348397 N/A physical interaction ComPPI
NME2 SMOC1 25348397 N/A physical interaction ComPPI
NME2 SLC48A1 25348397 N/A physical interaction ComPPI
NME2 APP 25348397 N/A physical interaction ComPPI
NME2 CFB 25348397 N/A physical interaction ComPPI
NME2 LRG1 25348397 N/A physical interaction ComPPI
NME2 DNM2 24234451 24970086 25348397 27898060 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct,OmniPath
NME2 IGKV2D-28 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NME2 ISYNA1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NME2 G3BP1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NME2 CBR1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NME2 RPS19 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NME2 RPS16 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NME2 PSMD12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NME2 RPN2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NME2 RANBP6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NME2 PPP2R2B 19156129 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NME2 AMOTL2 24234451 24255178 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NME2 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
NME2 PPTC7 24234451 25348397 27499296 28330616 association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
NME2 PHOSPHO1 24234451 25348397 28330616 association pull down ComPPI,IntAct
NME2 OCIAD1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
NME4 NME2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HPRT1 NME2 25348397 N/A physical interaction ComPPI
HINT1 NME2 25348397 N/A physical interaction ComPPI
TKT NME2 25348397 N/A physical interaction ComPPI
PTPN23 NME2 24234451 25348397 28330616 association pull down ComPPI,IntAct
DAO NME2 25348397 N/A physical interaction ComPPI
ATIC NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
AHCY NME2 25348397 N/A physical interaction ComPPI
NME2 NME2 14525934 21988832 24234451 8245015 physical association two hybrid,experimental interaction detection HPRD,IntAct
NME2 GNB1 12486122 27898060 N/A N/A OmniPath
CDK1 NME2 27898060 8245015 N/A N/A OmniPath
NME2 KCNN4 17157250 18796614 27898060 stimulant N/A OmniPath

Visualization










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