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GENE：RABGEF1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RABGEF1
FullNmae RAB guanine nucleotide exchange factor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17676
EnsembleID ENSG00000154710
Uniprot Q9UJ41

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RABGEF1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RABGEF1 GO:0001933,GO:0002686,GO:0003677,GO:0005085,GO:0005085,GO:0005085,GO:0005515,GO:0005730,GO:0005769,GO:0005829,GO:0005829,GO:0005829,GO:0006612,GO:0006898,GO:0007265,GO:0008270,GO:0030139,GO:0030425,GO:0031267,GO:0031267,GO:0031901,GO:0032715,GO:0032764,GO:0038109,GO:0043303,GO:0043305,GO:0046580,GO:0048261,GO:0050728,GO:0055037,GO:0060368,GO:0061630,GO:0097531,GO:0098935,GO:1900235

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RABGEF1 hsa:27342 path:hsa04137 Mitophagy - animal - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RABGEF1 KXD1 16189514 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 RABGEF1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 RABGEF1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA RABGEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RABGEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RABGEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 RABGEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC RABGEF1 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS00005E6F45 RABGEF1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075CC78 RABGEF1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 RABGEF1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000DD591 RABGEF1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000519450 RABGEF1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 RABGEF1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000C48FA RABGEF1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000ECE9C RABGEF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002ED720 RABGEF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000006B702 RABGEF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD RABGEF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000034979B RABGEF1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032BDF4 RABGEF1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002AB575 RABGEF1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000058BB84 RABGEF1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075D1FC RABGEF1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001383CF RABGEF1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00005ECFE5 RABGEF1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 RABGEF1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE RABGEF1 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
RABGEF1 RAB4A 25361965 interaction type N/A PTMCode2
RAB4A RABGEF1 25361965 interaction type N/A PTMCode2
RABEP1 RABGEF1 25361965 interaction type N/A PTMCode2
RABGEF1 RABEP1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
OIP5 RABGEF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TXN2 RABGEF1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TFPT RABGEF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAB4A RABGEF1 25348397 N/A in vitro,in vivo ComPPI
YWHAG RABGEF1 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,physical interaction ComPPI,IntAct
UBE2D1 RABGEF1 25348397 N/A physical interaction ComPPI
KXD1 RABGEF1 16189514 24234451 25348397 physical association two hybrid,pull down,physical interaction,two hybrid pooling approach ComPPI,IntAct
GGA2 RABGEF1 25348397 N/A in vitro ComPPI
MAPK1 RABGEF1 25348397 N/A physical interaction ComPPI
HRAS RABGEF1 25348397 N/A physical interaction ComPPI
CPNE2 RABGEF1 25348397 N/A physical interaction ComPPI
YWHAB RABGEF1 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,physical interaction,in vivo ComPPI,IntAct
UBB RABGEF1 16499958 24234451 25348397 association,physical association molecular sieving,pull down ComPPI,IntAct
UBC RABGEF1 15143060 16407276 16462746 16499958 17341663 21356307 22428841 22705550 25348397 25416956 27898060 N/A physical interaction ComPPI,OmniPath
RPS27A RABGEF1 25348397 N/A in vitro ComPPI
NTRK1 RABGEF1 25348397 N/A physical interaction ComPPI
HERC1 RABGEF1 25348397 N/A physical interaction ComPPI
L1CAM RABGEF1 25348397 N/A physical interaction ComPPI
TNFRSF1A RABGEF1 25348397 N/A physical interaction ComPPI
HMG20A RABGEF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
HGFAC RABGEF1 25348397 N/A physical interaction ComPPI
GOLGA5 RABGEF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABEP1 RABGEF1 25348397 N/A fluorescence polarization spectroscopy,physical interaction,physical interaction,in vitro ComPPI
RABGEF1 AP1G1 25348397 N/A two hybrid ComPPI
RABGEF1 RAB33B 25348397 N/A in vitro ComPPI
RABGEF1 GGA1 25348397 N/A physical interaction,in vitro ComPPI
RABGEF1 RNF168 25348397 N/A in vitro ComPPI
RABGEF1 RNF11 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RABGEF1 RAB5A 25348397 N/A physical interaction ComPPI
RABGEF1 ESR1 25348397 N/A physical interaction ComPPI
RABGEF1 KCTD7 25348397 N/A physical interaction ComPPI
RABGEF1 EEA1 21685908 24234451 25348397 colocalization physical interaction,confocal microscopy ComPPI,IntAct
RABGEF1 EGFR 16499958 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct
RABGEF1 RAB21 25348397 N/A x-ray crystallography,physical interaction,physical interaction ComPPI
RABGEF1 UBE2D3 25348397 N/A physical interaction ComPPI
RABGEF1 MON1A 25348397 N/A physical interaction ComPPI
RABGEF1 MON1B 25348397 N/A physical interaction ComPPI
RABGEF1 ROCK2 25348397 N/A physical interaction ComPPI
RABGEF1 TNKS1BP1 25348397 N/A physical interaction ComPPI
RABGEF1 DGCR6 25348397 N/A physical interaction ComPPI
RABGEF1 TEAD4 25348397 N/A physical interaction ComPPI
RABGEF1 DAZAP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RABGEF1 THOC1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RABGEF1 BLOC1S6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RABGEF1 TRIM54 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RABGEF1 ZC2HC1C 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RABGEF1 TRIM15 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RABGEF1 CCDC183 25348397 N/A physical interaction ComPPI
RABGEF1 CRBN 25348397 N/A physical interaction ComPPI
RABGEF1 RABEP2 25348397 N/A physical interaction ComPPI
RABGEF1 CPNE5 25348397 N/A physical interaction ComPPI
RABGEF1 RBCK1 25348397 N/A physical interaction ComPPI
RABGEF1 OTUD5 25348397 N/A physical interaction ComPPI
RABGEF1 SHARPIN 25348397 N/A physical interaction ComPPI
RABGEF1 EXOC1 25348397 N/A physical interaction ComPPI
RABGEF1 RNF31 25348397 N/A physical interaction ComPPI
RABGEF1 BIRC2 25348397 N/A physical interaction ComPPI
RABGEF1 GAK 25348397 N/A physical interaction ComPPI
RABGEF1 TAX1BP1 25348397 N/A physical interaction ComPPI
RABGEF1 CYHR1 25348397 N/A physical interaction ComPPI
RABGEF1 VTI1B 25348397 N/A physical interaction ComPPI
RABGEF1 FAM189B 25348397 N/A physical interaction ComPPI
RABGEF1 TRAF2 25348397 N/A physical interaction ComPPI
RABGEF1 UBR1 25348397 N/A physical interaction ComPPI
RABGEF1 CLINT1 25348397 N/A physical interaction ComPPI
RABGEF1 KCTD10 25348397 N/A physical interaction ComPPI
RABGEF1 PKN3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 NCKAP5L 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 CCHCR1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 YEATS4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 TUFT1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 RABGAP1L 25348397 N/A physical interaction ComPPI
RABGEF1 RABGAP1L 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 CLOCK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 PSMD9 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 VPS53 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 DZIP3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 GRIPAP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 RCOR1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 VPS50 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 GIT2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 CCDC93 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 PHF21A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 CAVIN1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 PHLDB3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 HAUS6 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 RPRD1A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 ARNTL 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 MAX 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 NUF2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RABGEF1 TRIM25 25348397 N/A physical interaction ComPPI
RABGEF1 SNAPIN 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
RABGEF1 GOLM1 24234451 25348397 27569582 association anti tag coimmunoprecipitation ComPPI,IntAct
RABGEF1 RAB11A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB22A RABGEF1 25348397 N/A physical interaction ComPPI
THAP11 RABGEF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SLMAP RABGEF1 24234451 24255178 24366813 25348397 colocalization,association anti tag coimmunoprecipitation,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CIPC RABGEF1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RABGEF1 RABGEF1 16499958 24234451 25416956 association,physical association pull down,two hybrid array IntAct
RABGEF1 DNAJC5 24234451 29997244 physical association bioluminescence resonance energy transfer IntAct
RABEP1 RABGEF1 10720461 11452015 12505986 17341663 17450153 24957337 27898060 9323142 9524116 stimulant N/A OmniPath
RABGEF1 RAB5A 10720461 11452015 19759177 23048039 27898060 stimulant N/A OmniPath

Visualization










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