GENE：PPP2R5C
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PPP2R5C |
| FullNmae | protein phosphatase 2 regulatory subunit B'gamma |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9311 |
| EnsembleID | ENSG00000078304 |
| Uniprot | Q13362 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PPP2R5C | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PPP2R5C | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PPP2R5C | GO:0000159,GO:0000159,GO:0000159,GO:0000775,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005794,GO:0005829,GO:0005829,GO:0005829,GO:0006470,GO:0007165,GO:0008285,GO:0019888,GO:0043161,GO:0072542 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PPP2R5C | hsa:5527 | path:hsa03015 | mRNA surveillance pathway - Homo sapiens (human) |
| PPP2R5C | hsa:5527 | path:hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| PPP2R5C | hsa:5527 | path:hsa04110 | Cell cycle - Homo sapiens (human) |
| PPP2R5C | hsa:5527 | path:hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| PPP2R5C | hsa:5527 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| PPP2R5C | hsa:5527 | path:hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| PPP2R5C | hsa:5527 | path:hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| PPP2R5C | hsa:5527 | path:hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| PPP2R5C | hsa:5527 | path:hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| PPP2R5C | hsa:5527 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PPP2R5C | CHEK2 | 20005715 | interaction type | N/A | PSP |
| PPP2R5C | MAPK1 | 20005715 | interaction type | N/A | PSP,SignaLink |
| PPP2R5C | PPP2CA | 10675325 18782753 19156129 20005715 21071413 | interaction type | N/A | PSP,SignaLink |
| PPP2R5C | PRKCD | 20005715 | interaction type | N/A | PSP |
| PPP2R5C | EP300 | 20005715 | interaction type | N/A | PSP |
| PPP2R5C | EP300 | 15632055 18988627 20005715 20005715 | N/A | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PPP2R5C | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | PPP2R5C | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | PPP2R5C | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | PPP2R5C | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | PPP2R5C | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | PPP2R5C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PPP2R5C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PPP2R5C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | PPP2R5C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PPP2R5C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PPP2R5C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PPP2R5C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | PPP2R5C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PPP2R5C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PPP2R5C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | PPP2R5C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | PPP2R5C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | PPP2R5C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000065D58 | PPP2R5C | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS0000001EB3 | PPP2R5C | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000001C659 | PPP2R5C | 23594704 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000171CD1 | PPP2R5C | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000008F0CF | PPP2R5C | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041CB9C | PPP2R5C | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040EE1D | PPP2R5C | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F0F49 | PPP2R5C | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007D64A | PPP2R5C | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000427B68 | PPP2R5C | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005ACA7C | PPP2R5C | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002AB575 | PPP2R5C | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000475586 | PPP2R5C | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D860 | PPP2R5C | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272A3D | PPP2R5C | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272A92 | PPP2R5C | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F6E49 | PPP2R5C | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000043C1C3 | PPP2R5C | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AA464 | PPP2R5C | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000367985 | PPP2R5C | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKAA1 | PPP2R5C | 22135298 | phosphorylation | N/A | PhosphoSite |
| ATM | PPP2R5C | 22135298 | phosphorylation | N/A | PhosphoSite |
| PPP2CA | PPP2R5C | 25361965 | interaction type | N/A | PTMCode2 |
| PPP2R5C | PPP2CA | 25361965 | interaction type | N/A | PTMCode2 |
| PPP2R1A | PPP2R5C | 25361965 | interaction type | N/A | PTMCode2 |
| PPP2R5C | PPP2R1A | 25361965 | interaction type | N/A | PTMCode2 |
| PPP2R1B | PPP2R5C | 25361965 | interaction type | N/A | PTMCode2 |
| PPP2R5C | PPP2R1B | 25361965 | interaction type | N/A | PTMCode2 |
| AXIN1 | PPP2R5C | 25361965 | interaction type | N/A | PTMCode2 |
| PPP2R5C | AXIN1 | 25361965 | interaction type | N/A | PTMCode2 |
| PPM1A | PPP2R5C | 25361965 | interaction type | N/A | PTMCode2 |
| PPP2R5C | PPM1A | 25361965 | interaction type | N/A | PTMCode2 |
| PPP2R5A | PPP2R5C | 25361965 | interaction type | N/A | PTMCode2 |
| PPP2R5C | PPP2R5A | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PPP1CC | PPP2R5C | 24234451 25348397 25487150 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| PPP2R1A | PPP2R5C | 17245430 18782753 19915589 21460856 24234451 25348397 27173435 28330616 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,tandem affinity purification,proximity-dependent biotin identification,inference by socio-affinity scoring | ComPPI,IntAct |
| LSM6 | PPP2R5C | 25348397 | N/A | physical interaction | ComPPI |
| PPP1CB | PPP2R5C | 24234451 25348397 25487150 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| LSM7 | PPP2R5C | 25348397 | N/A | physical interaction | ComPPI |
| SWAP70 | PPP2R5C | 25348397 | N/A | physical interaction | ComPPI |
| MAPK1 | PPP2R5C | 16456541 24234451 25348397 | phosphorylation reaction | physical interaction,protein kinase assay | ComPPI,IntAct |
| PRKCD | PPP2R5C | 11959144 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| EP300 | PPP2R5C | 14525934 15632055 24234451 25348397 27898060 | physical association | experimental interaction detection,pull down,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct,OmniPath |
| PAXIP1 | PPP2R5C | 25348397 | N/A | physical interaction | ComPPI |
| FAF1 | PPP2R5C | 25348397 | N/A | physical interaction | ComPPI |
| AXIN1 | PPP2R5C | 10698523 14525934 17510365 24234451 25348397 | association | experimental interaction detection,in vivo,tandem affinity purification | ComPPI,HPRD,IntAct |
| PPP2R5A | PPP2R5C | 25348397 | N/A | physical interaction | ComPPI |
| PPP1CA | PPP2R5C | 24234451 25348397 25487150 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| PXN | PPP2R5C | 25348397 | N/A | in vivo | ComPPI |
| PPP2CB | PPP2R5C | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
| IER3 | PPP2R5C | 16456541 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction,in vitro | ComPPI,IntAct |
| PPP2R5C | PPP2R1B | 11929880 14525934 16456541 17540176 24234451 25348397 | physical association | anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| PPP2R5C | PPP2CA | 11929880 1328865 14525934 16456541 18782753 19156129 19915589 21460856 24234451 25348397 28330616 7592815 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo,tandem affinity purification | ComPPI,HPRD,IntAct |
| PPP2R5C | CHEK2 | 14525934 15380617 23178491 24234451 25348397 | association | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification,two hybrid | ComPPI,HPRD,IntAct |
| PPP2R5C | CCNG2 | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | MBP | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | TBC1D3C | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | TBC1D3 | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | APP | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | BRCA1 | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | CERT1 | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | JMJD6 | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | PACSIN2 | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | UGP2 | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | PSMG3 | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | EGFR | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | FAM43A | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | CCNG1 | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | API5 | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | PPP2R2A | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | POLD1 | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | PPP2R5E | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | CNOT9 | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | TP53 | 17245430 21460856 24234451 25241761 25348397 | association,physical association | anti bait coimmunoprecipitation,physical interaction,proximity ligation assay | ComPPI,IntAct |
| PPP2R5C | PRR14 | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R5C | ATM | 21460856 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PPP2R5C | MDM2 | 21460856 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PPP2R5C | RAF1 | 16239230 24234451 25348397 | dephosphorylation reaction,physical association | anti tag coimmunoprecipitation,phosphatase assay | ComPPI,IntAct |
| PPP2R5C | DZIP1 | 21878643 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| SOX2 | PPP2R5C | 25348397 | N/A | physical interaction | ComPPI |
| SGO1 | PPP2R5C | 14525934 16541024 16541025 | N/A | experimental interaction detection | HPRD |
| PPP2R5C | CACNA1C | 10984483 27898060 | stimulant | N/A | OmniPath |
| PPP2R5C | CREB1 | 27898060 8195196 8386317 | inhibition | N/A | OmniPath |
| PPP2R5C | ATF1 | 20730097 27898060 | stimulant | N/A | OmniPath |
| CHEK2 | PPP2R5C | 15380617 27898060 | stimulant | N/A | OmniPath |
| CASP3 | PPP2R5C | 27898060 9582351 | inhibition | N/A | OmniPath |
| PPP2R5C | BCL2 | 27898060 9852076 | inhibition | N/A | OmniPath |
| PPP2R5C | BAD | 11222372 27898060 | stimulant | N/A | OmniPath |
| ATM | PPP2R5C | 21460856 27898060 | stimulant | N/A | OmniPath |
| PPP2R5C | AKT1 | 11897496 21159657 27898060 | inhibition | N/A | OmniPath |
| PPP2R5C | CFL1 | 11093160 27898060 | stimulant | N/A | OmniPath |
| PPP2R5C | GSK3A | 11897496 27898060 8524413 | stimulant | N/A | OmniPath |
| MAPK3 | PPP2R5C | 16456541 27898060 | inhibition | N/A | OmniPath |
| PPP2R5C | MAPK3 | 16456541 27898060 | inhibition | N/A | OmniPath |
| IER3 | PPP2R5C | 16456541 27898060 | inhibition | N/A | OmniPath |
| PPP2R5C | BCAR1 | 11593413 27898060 | inhibition | N/A | OmniPath |
| MAPK1 | PPP2R5C | 16456541 27898060 | inhibition | N/A | OmniPath |
| PPP2R5C | MAPK1 | 16456541 27898060 | inhibition | N/A | OmniPath |
| CAMK2A | PPP2R5C | 10646534 27898060 | inhibition | N/A | OmniPath |
| PPP2R5C | RPS6KB1 | 20444422 27898060 | inhibition | N/A | OmniPath |
| PPP2R5C | GRIN2A | 27898060 8183343 | inhibition | N/A | OmniPath |
| PPP2R5C | CAMK1 | 1320022 27898060 | inhibition | N/A | OmniPath |
| PPP2R5C | NEFH | 27898060 7760048 | inhibition | N/A | OmniPath |
| PPP2R5C | CAMK4 | 15143065 27898060 9596578 | inhibition | N/A | OmniPath |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00009AFC68 | PPP2R5C | 27087310 | direct interaction,inhibition | N/A | NPInter |