GENE：RELN
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | RELN |
| FullNmae | reelin |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9957 |
| EnsembleID | ENSG00000189056 |
| Uniprot | P78509 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| RELN | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| RELN | GO:0000902,GO:0001764,GO:0001764,GO:0001934,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005737,GO:0005886,GO:0006508,GO:0007155,GO:0007411,GO:0007417,GO:0007417,GO:0007420,GO:0007616,GO:0007626,GO:0008236,GO:0008306,GO:0010001,GO:0010976,GO:0016358,GO:0018108,GO:0021511,GO:0021517,GO:0021766,GO:0021800,GO:0021819,GO:0030425,GO:0031012,GO:0032008,GO:0032793,GO:0035418,GO:0038026,GO:0038026,GO:0043005,GO:0045664,GO:0045860,GO:0046872,GO:0048265,GO:0050731,GO:0050795,GO:0050804,GO:0051057,GO:0051968,GO:0060025,GO:0060291,GO:0061003,GO:0061098,GO:0070325,GO:0070325,GO:0070326,GO:0090129,GO:0097114,GO:0097119,GO:0097120,GO:0097477,GO:0110157,GO:1900273,GO:1902078,GO:1904936,GO:2000310,GO:2000463,GO:2000969,GO:2001222 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| RELN | hsa:5649 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| RELN | hsa:5649 | path:hsa04510 | Focal adhesion - Homo sapiens (human) |
| RELN | hsa:5649 | path:hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
| RELN | hsa:5649 | path:hsa05017 | Spinocerebellar ataxia - Homo sapiens (human) |
| RELN | hsa:5649 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA1 | RELN | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | RELN | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| PRDM14 | RELN | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | RELN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | RELN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | RELN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | RELN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | RELN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | RELN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | RELN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | RELN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | RELN | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DNMT1 | RELN | 19029285 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HDAC1 | RELN | 19029285 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MECP2 | RELN | 19029285 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TBR1 | RELN | 19165920 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| VLDLR | RELN | 25361965 | interaction type | N/A | PTMCode2 |
| RELN | VLDLR | 25361965 | interaction type | N/A | PTMCode2 |
| DAB1 | RELN | 25361965 | interaction type | N/A | PTMCode2 |
| RELN | DAB1 | 25361965 | interaction type | N/A | PTMCode2 |
| LRP8 | RELN | 25361965 | interaction type | N/A | PTMCode2 |
| RELN | LRP8 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| COPS5 | RELN | 25348397 | N/A | physical interaction | ComPPI |
| DAB1 | RELN | 11137154 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| VLDLR | RELN | 10571240 10571241 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| LRP8 | RELN | 10571240 12167620 12670700 12899622 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| SQSTM1 | RELN | 25348397 | N/A | physical interaction | ComPPI |
| RELN | PCDHA4 | 10612399 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| RELN | PCDHA6 | 10612399 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| RELN | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
| RELN | RELN | 12135781 14525934 | N/A | experimental interaction detection | HPRD |
| RELN | ITGB1 | 10725376 10939329 27898060 | inhibition | N/A | OmniPath |
| RELN | ITGA3 | 10939329 27898060 | stimulant | N/A | OmniPath |
| RELN | VLDLR | 10571240 10571241 11278667 12670700 12899622 27898060 | stimulant | N/A | OmniPath |