GENE：SLC6A6
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SLC6A6 |
| FullNmae | solute carrier family 6 member 6 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11052 |
| EnsembleID | ENSG00000131389 |
| Uniprot | P31641 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SLC6A6 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SLC6A6 | GO:0005283,GO:0005332,GO:0005332,GO:0005368,GO:0005368,GO:0005368,GO:0005369,GO:0005369,GO:0005369,GO:0005886,GO:0005886,GO:0005886,GO:0006836,GO:0006865,GO:0015171,GO:0015171,GO:0015185,GO:0015734,GO:0015734,GO:0015734,GO:0015734,GO:0015734,GO:0016020,GO:0016323,GO:0016324,GO:0022858,GO:0030425,GO:0031528,GO:0032328,GO:0035725,GO:0043025,GO:0045211,GO:0045597,GO:0050804,GO:0051939,GO:0071705,GO:0089718,GO:0098739,GO:0098797,GO:0098982,GO:0150104 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SLC6A6 | 18971253 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ETS1 | SLC6A6 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | SLC6A6 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| TFAP2C | SLC6A6 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | SLC6A6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SLC6A6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SLC6A6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | SLC6A6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SLC6A6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SLC6A6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | SLC6A6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SLC6A6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | SLC6A6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | SLC6A6 | 16734743 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | SLC6A6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETV4 | SLC6A6 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| WT1 | SLC6A6 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | SLC6A6 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000ED600 | SLC6A6 | 20215506 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000BE495 | SLC6A6 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000021D7C8 | SLC6A6 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00001CC864 | SLC6A6 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000016FF9C | SLC6A6 | 24304186 25416803 | mrna cleavage,inhibition | quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS0000085F64 | SLC6A6 | 21572407 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000076B539 | SLC6A6 | 21572407 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272A92 | SLC6A6 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000330617 | SLC6A6 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000016C318 | SLC6A6 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NMUR2 | SLC6A6 | 25348397 | N/A | physical interaction | ComPPI |
| PDZK1 | SLC6A6 | 25348397 | N/A | physical interaction | ComPPI |
| TMEM216 | SLC6A6 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| PDZK1P1 | SLC6A6 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9 | SLC6A6 | 25348397 | N/A | physical interaction | ComPPI |
| GPR21 | SLC6A6 | 25348397 | N/A | physical interaction | ComPPI |
| ADGRG5 | SLC6A6 | 25348397 | N/A | physical interaction | ComPPI |
| SLC6A6 | TMEM17 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| HSPA5 | SLC6A6 | 24234451 30021884 | physical association | cross-linking study | IntAct |