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GENE：SOCS6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SOCS6
FullNmae suppressor of cytokine signaling 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16833
EnsembleID ENSG00000170677
Uniprot O14544

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SOCS6 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SOCS6 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SOCS6 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SOCS6 GO:0001772,GO:0005515,GO:0005737,GO:0005829,GO:0005942,GO:0006952,GO:0007259,GO:0009968,GO:0010498,GO:0016567,GO:0035556,GO:0040008,GO:0046854,GO:0046935,GO:0050868

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SOCS6 hsa:9306 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
SOCS6 hsa:9306 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CUL5 SOCS6 21145461 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
SOCS6 BMPR1B 20005715 interaction type N/A PSP
SOCS6 PIK3R2 20005715 interaction type N/A PSP
SOCS6 INSR 20005715 interaction type N/A PSP
SOCS6 TGFBR1 20005715 interaction type N/A PSP
SOCS6 ACVR1 20005715 interaction type N/A PSP
SOCS6 SMURF2 20005715 interaction type N/A PSP
SOCS6 SMURF2 20005715 N/A N/A SignaLink
SOCS6 TGFBR1 15761153 18988627 20005715 N/A N/A SignaLink
SOCS6 ACVR1 20005715 20005715 N/A N/A SignaLink
SOCS6 BMPR1B 20005715 20005715 N/A N/A SignaLink
SOCS6 INSR 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR SOCS6 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 SOCS6 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 SOCS6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 SOCS6 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SOCS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SOCS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SOCS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SOCS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SOCS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SOCS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A SOCS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SOCS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SOCS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 SOCS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SOCS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 SOCS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004DA9DB SOCS6 22917968 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00004DA9DB SOCS6 22917968 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000183BED SOCS6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F0F49 SOCS6 23653113 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00002075FA SOCS6 24801601 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000285DCB SOCS6 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFEC1 SOCS6 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000086A4D SOCS6 24584142 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS00001012BC SOCS6 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 SOCS6 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000046CDA6 SOCS6 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000338542 SOCS6 25416803 26692956 27570566 27811366 mrna cleavage,inhibition nucleotide sequence identification,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000009262D SOCS6 25416803 27570566 27811366 mrna cleavage,inhibition nucleotide sequence identification,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001CC864 SOCS6 25416803 27570566 mrna cleavage,inhibition nucleotide sequence identification,quantitative reverse transcription pcr TarBase
URS000003ABC4 SOCS6 25416803 27570566 mrna cleavage,inhibition nucleotide sequence identification,quantitative reverse transcription pcr TarBase
URS00001B341F SOCS6 25416803 27570566 mrna cleavage,inhibition nucleotide sequence identification,quantitative reverse transcription pcr TarBase
URS0000330617 SOCS6 25416803 27570566 mrna cleavage,inhibition nucleotide sequence identification,quantitative reverse transcription pcr TarBase
URS00001DE669 SOCS6 25416803 27570566 mrna cleavage,inhibition nucleotide sequence identification,quantitative reverse transcription pcr TarBase
URS00001E0AEA SOCS6 25416803 27570566 mrna cleavage,inhibition nucleotide sequence identification,quantitative reverse transcription pcr TarBase
URS0000345DEB SOCS6 25416803 26870180 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
KIT SOCS6 25361965 interaction type N/A PTMCode2
SOCS6 KIT 25361965 interaction type N/A PTMCode2
SOCS6 RBCK1 25361965 interaction type N/A PTMCode2
RBCK1 SOCS6 25361965 interaction type N/A PTMCode2
SOCS6 IRS4 25361965 interaction type N/A PTMCode2
IRS4 SOCS6 25361965 interaction type N/A PTMCode2
SOCS6 IRS2 25361965 interaction type N/A PTMCode2
IRS2 SOCS6 25361965 interaction type N/A PTMCode2
INSR SOCS6 25361965 interaction type N/A PTMCode2
SOCS6 INSR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIK3R2 SOCS6 12052866 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
UBE2I SOCS6 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CUL5 SOCS6 25348397 N/A physical interaction ComPPI
FRS3 SOCS6 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
AMOT SOCS6 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
DCUN1D1 SOCS6 25348397 N/A physical interaction ComPPI
HSP90AB1 SOCS6 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
CRK SOCS6 25348397 N/A two hybrid,physical interaction ComPPI
APPL1 SOCS6 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
SMURF2 SOCS6 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
KIT SOCS6 14525934 14707129 24234451 24728074 25348397 N/A two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PIK3R1 SOCS6 12052866 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
AR SOCS6 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
POLA1 SOCS6 25348397 N/A physical interaction ComPPI
UBE2D2 SOCS6 25348397 N/A physical interaction ComPPI
IRS2 SOCS6 12052866 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
IRS4 SOCS6 12052866 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GAB1 SOCS6 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
PIK3R3 SOCS6 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HSP90AA1 SOCS6 25348397 N/A physical interaction ComPPI
DAB1 SOCS6 25348397 N/A physical interaction ComPPI
PLEC SOCS6 25348397 N/A physical interaction ComPPI
RELA SOCS6 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MET SOCS6 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
EGFR SOCS6 24234451 24658140 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
TUBA1A SOCS6 12052866 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
YAP1 SOCS6 24234451 25180228 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct,OmniPath
TXK SOCS6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BMPR1B SOCS6 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TUBB4B SOCS6 12052866 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MADD SOCS6 25348397 N/A physical interaction ComPPI
ELOB SOCS6 12052866 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ELOC SOCS6 12052866 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
EFEMP1 SOCS6 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
INSR SOCS6 11342531 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ACVR1 SOCS6 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SOCS6 RBCK1 14525934 16643902 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
SOCS6 TUBD1 25348397 N/A physical interaction ComPPI
SOCS6 HSP90AA2P 25348397 N/A physical interaction ComPPI
SOCS6 WDR89 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SOCS6 ZMIZ2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SOCS6 KDM1A 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SOCS6 CDK5RAP2 25348397 N/A physical interaction ComPPI
SOCS6 FBXO11 25348397 N/A physical interaction ComPPI
SOCS6 ACACA 25348397 N/A physical interaction ComPPI
SOCS6 USP1 25348397 N/A physical interaction ComPPI
SOCS6 SAV1 25348397 N/A physical interaction ComPPI
SOCS6 KIAA0232 25348397 N/A physical interaction ComPPI
SOCS6 FAM83H 25348397 N/A physical interaction ComPPI
SOCS6 LNX1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
SOCS6 CLNK 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
SOCS6 C1ORF109 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ARIH2 SOCS6 25348397 N/A physical interaction ComPPI
SOCS6 TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
SOCS6 FLT3 22952242 24234451 27898060 28086240 N/A protein array IntAct,OmniPath
API5 SOCS6 24234451 30021884 physical association cross-linking study IntAct
SOCS6 LCK 20007709 27898060 N/A N/A OmniPath
SOCS6 KIT 14707129 21030588 24728074 27898060 inhibition N/A OmniPath

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