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GENE：VCL

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol VCL
FullNmae vinculin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12665
EnsembleID ENSG00000035403
Uniprot P18206

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
VCL mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
VCL autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
VCL GO:0002009,GO:0002162,GO:0003779,GO:0005198,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0005856,GO:0005856,GO:0005886,GO:0005911,GO:0005911,GO:0005912,GO:0005912,GO:0005912,GO:0005916,GO:0005925,GO:0005925,GO:0005925,GO:0005925,GO:0005925,GO:0007155,GO:0007155,GO:0007160,GO:0008013,GO:0008013,GO:0030032,GO:0030055,GO:0030336,GO:0031625,GO:0032991,GO:0034333,GO:0034394,GO:0034774,GO:0035580,GO:0035633,GO:0042383,GO:0042995,GO:0043034,GO:0043034,GO:0043297,GO:0044291,GO:0044291,GO:0045294,GO:0045294,GO:0045296,GO:0045296,GO:0048675,GO:0051893,GO:0051893,GO:0061826,GO:0070062,GO:0070527,GO:0090136,GO:1903140,GO:1903561,GO:1904702,GO:1904813

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
VCL hsa:7414 path:hsa04510 Focal adhesion - Homo sapiens (human)
VCL hsa:7414 path:hsa04520 Adherens junction - Homo sapiens (human)
VCL hsa:7414 path:hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
VCL hsa:7414 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
VCL hsa:7414 path:hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)
VCL hsa:7414 path:hsa05131 Shigellosis - Homo sapiens (human)
VCL hsa:7414 path:hsa05146 Amoebiasis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDH1 VCL 17664339 23180781 9405455 9535896 physical association anti tag coimmunoprecipitation InnateDB
CTNNB1 VCL 23180781 9405455 physical association anti tag coimmunoprecipitation InnateDB
EIF4E VCL 16189514 23180781 physical association two hybrid pooling approach InnateDB
IL7R VCL 20167604 23180781 physical association anti tag coimmunoprecipitation InnateDB
VCL SELE 23180781 8609175 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR VCL 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 VCL 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 VCL 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 VCL 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 VCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA VCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF VCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 VCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 VCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 VCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 VCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS VCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A VCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 VCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 VCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 VCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 VCL 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00002C0FCB VCL 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD VCL 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 VCL 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000202460 VCL 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000009A9A2 VCL 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 VCL 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000032EF64 VCL 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000237CBD VCL 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D VCL 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000000B1C9 VCL 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000A07C1 VCL 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 VCL 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 VCL 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002578DA VCL 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000334286 VCL 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D VCL 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C VCL 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 VCL 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
VCL VASP 25361965 interaction type N/A PTMCode2
VASP VCL 25361965 interaction type N/A PTMCode2
VCL CDH1 25361965 interaction type N/A PTMCode2
CDH1 VCL 25361965 interaction type N/A PTMCode2
VCL PRKCA 25361965 interaction type N/A PTMCode2
PRKCA VCL 25361965 interaction type N/A PTMCode2
VCL SORBS2 25361965 interaction type N/A PTMCode2
SORBS2 VCL 25361965 interaction type N/A PTMCode2
VCL RAVER1 25361965 interaction type N/A PTMCode2
RAVER1 VCL 25361965 interaction type N/A PTMCode2
VCL TLN2 25361965 interaction type N/A PTMCode2
TLN2 VCL 25361965 interaction type N/A PTMCode2
VCL CTNNA1 25361965 interaction type N/A PTMCode2
CTNNA1 VCL 25361965 interaction type N/A PTMCode2
VCL TLN1 25361965 interaction type N/A PTMCode2
TLN1 VCL 25361965 interaction type N/A PTMCode2
VCL CTNNB1 25361965 interaction type N/A PTMCode2
CTNNB1 VCL 25361965 interaction type N/A PTMCode2
VCL SRC 25361965 interaction type N/A PTMCode2
SRC VCL 25361965 interaction type N/A PTMCode2
VCL TGFB1I1 25361965 interaction type N/A PTMCode2
TGFB1I1 VCL 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GNAI3 VCL 25348397 N/A physical interaction ComPPI
VASP VCL 10882740 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
ACTG1 VCL 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNRPF VCL 25348397 N/A physical interaction ComPPI
VCP VCL 25348397 N/A physical interaction ComPPI
YWHAG VCL 25348397 N/A physical interaction ComPPI
PPP1R2B VCL 25348397 N/A physical interaction ComPPI
PDCD10 VCL 25348397 N/A physical interaction ComPPI
TEKT1 VCL 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
AP3M1 VCL 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF5 VCL 25348397 N/A physical interaction ComPPI
PRKCA VCL 11741957 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SRC VCL 14525934 15229287 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MPDZ VCL 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TBCB VCL 25348397 N/A physical interaction ComPPI
ITGB1 VCL 25348397 N/A physical interaction ComPPI
SORBS1 VCL 10085297 14525934 17082770 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RAP1GDS1 VCL 25348397 N/A physical interaction ComPPI
YWHAZ VCL 15161933 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
RPS27A VCL 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBE2N VCL 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ACTN1 VCL 14525934 15988023 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NTRK1 VCL 25348397 N/A physical interaction ComPPI
PICALM VCL 25348397 N/A physical interaction ComPPI
USO1 VCL 25348397 N/A physical interaction ComPPI
CDH1 VCL 25348397 N/A physical interaction,in vitro ComPPI
PKD1 VCL 11113628 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRPF40A VCL 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
TLN1 VCL 14525934 15070891 15988023 24234451 25348397 26496610 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
HSPA5 VCL 25348397 N/A physical interaction ComPPI
PDIA4 VCL 25348397 N/A physical interaction ComPPI
PXN VCL 20308429 24234451 25348397 colocalization physical interaction,fluorescence microscopy,in vitro,in vivo ComPPI,IntAct
TRIP6 VCL 14525934 16189514 21516116 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MKNK2 VCL 25348397 N/A physical interaction ComPPI
VCL NRAP 10320340 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
VCL CORO2B 10224093 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
VCL RAVER1 11724819 14525934 25348397 N/A two hybrid,experimental interaction detection,isothermal titration calorimetry,molecular sieving,x-ray crystallography,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
VCL SORBS2 10521485 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
VCL CTNNA1 14525934 24234451 25348397 26496610 9700171 association anti tag coimmunoprecipitation,experimental interaction detection,molecular sieving,physical interaction,comigration in non denaturing gel electrophoresis,in vitro,in vivo ComPPI,HPRD,IntAct
VCL CLTC 14525934 25348397 27898060 8276759 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
VCL ABI2 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
VCL BRME1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
VCL ACTA1 14525934 25348397 7816144 N/A experimental interaction detection,in vitro ComPPI,HPRD
VCL PSME1 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
VCL SELE 14525934 25348397 8609175 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
VCL GSN 11577104 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
VCL CTNNB1 25348397 N/A physical interaction ComPPI
VCL TGFB1I1 25348397 N/A physical interaction ComPPI
VCL BCAR1 25348397 N/A physical interaction ComPPI
VCL DAG1 25348397 N/A physical interaction ComPPI
VCL TUBA1A 25348397 N/A physical interaction ComPPI
VCL SIRT7 25348397 N/A physical interaction ComPPI
VCL CDK2 25348397 N/A physical interaction ComPPI
VCL DNAJC5 25348397 N/A physical interaction ComPPI
VCL TXNL1 25348397 N/A physical interaction ComPPI
VCL SCAF4 25348397 N/A physical interaction ComPPI
VCL URM1 25348397 N/A physical interaction ComPPI
VCL ZC3HAV1L 25348397 N/A physical interaction ComPPI
VCL SVIL 25348397 N/A physical interaction ComPPI
VCL SSU72 25348397 N/A physical interaction ComPPI
VCL SDHAF2 25348397 N/A physical interaction ComPPI
VCL UBR1 25348397 N/A physical interaction ComPPI
VCL VAPB 25348397 N/A physical interaction ComPPI
VCL ATP6V1A 25348397 N/A physical interaction ComPPI
VCL UBA3 25348397 N/A physical interaction ComPPI
VCL TPI1 25348397 N/A physical interaction ComPPI
VCL UFC1 25348397 N/A physical interaction ComPPI
VCL VCAM1 19738201 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
VCL FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
VCL ITGA4 25348397 N/A physical interaction ComPPI
VCL ASNS 25348397 N/A physical interaction ComPPI
VCL CTPS1 25348397 N/A physical interaction ComPPI
VCL ECHS1 25348397 N/A physical interaction ComPPI
VCL FERMT2 25348397 N/A physical interaction ComPPI
VCL GINS3 25348397 N/A physical interaction ComPPI
VCL GSS 25348397 N/A physical interaction ComPPI
VCL MSN 25348397 N/A physical interaction ComPPI
VCL PDHA1 25348397 N/A physical interaction ComPPI
VCL PPP1R2 25348397 N/A physical interaction ComPPI
VCL PPP5C 25348397 N/A physical interaction ComPPI
VCL SFN 25348397 N/A physical interaction ComPPI
VCL STK24 25348397 N/A physical interaction ComPPI
VCL MC1R 25348397 N/A physical interaction ComPPI
VCL TUBB3 25348397 N/A physical interaction ComPPI
VCL UBFD1 25348397 N/A physical interaction ComPPI
VCL DCPS 25348397 N/A physical interaction ComPPI
VCL ERP44 25348397 N/A physical interaction ComPPI
VCL G6PD 25348397 N/A physical interaction ComPPI
VCL PFAS 25348397 N/A physical interaction ComPPI
VCL XPO1 25348397 N/A physical interaction ComPPI
VCL YWHAE 25348397 N/A physical interaction ComPPI
VCL YWHAH 25348397 N/A physical interaction ComPPI
VCL ASB7 25348397 N/A physical interaction ComPPI
VCL UNK 25348397 N/A physical interaction ComPPI
VCL EWSR1 25348397 N/A physical interaction ComPPI
VCL FBF1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
VCL LPXN 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VCL CAPZB 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
VCL MYO1C 25348397 N/A physical interaction ComPPI
VCL SPTAN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VCL SEC16A 25348397 N/A physical interaction ComPPI
VCL CDCA5 25348397 N/A physical interaction ComPPI
VCL LIMA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VCL PPHLN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VCL RBM26 25348397 N/A physical interaction ComPPI
VCL GKAP1 25348397 N/A physical interaction ComPPI
VCL ASCC2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VCL TRIM15 25348397 N/A physical interaction ComPPI
VCL PAK4 25348397 N/A physical interaction ComPPI
VCL FOCAD 25348397 N/A physical interaction ComPPI
VCL TTC21B 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
VCL HSD17B10 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
VCL TRIM25 25348397 N/A physical interaction ComPPI
VCL BRCA1 25348397 N/A physical interaction ComPPI
VCL CFTR 25348397 N/A physical interaction ComPPI
VCL NDEL1 19492042 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VCL BIRC6 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
VCL POMP 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
VCL ARPC2 12473693 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
YWHAQ VCL 25348397 N/A physical interaction ComPPI
HSPA9 VCL 25348397 N/A physical interaction ComPPI
ISOC1 VCL 25348397 N/A physical interaction ComPPI
VCL VCL 24234451 25416956 physical association two hybrid array IntAct
H1-5 VCL 24234451 30021884 physical association cross-linking study IntAct
SRC VCL 15229287 27898060 inhibition N/A OmniPath
PRKCA VCL 11741957 15229287 27898060 stimulant N/A OmniPath
IL7R VCL 20167604 27898060 N/A N/A OmniPath
VCL EIF4E 16189514 27898060 N/A N/A OmniPath

Visualization










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