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GENE：EIF3L

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EIF3L
FullNmae eukaryotic translation initiation factor 3 subunit L
LocusType gene with protein product
Status Approved
HGNC_id HGNC:18138
EnsembleID ENSG00000100129
Uniprot Q9Y262

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EIF3L pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EIF3L autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EIF3L GO:0001650,GO:0001732,GO:0003723,GO:0003743,GO:0003743,GO:0005515,GO:0005654,GO:0005829,GO:0005852,GO:0005852,GO:0005852,GO:0006413,GO:0006413,GO:0006413,GO:0016020,GO:0016282,GO:0033290,GO:0045202,GO:0075525

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RNF2 EIF3L 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR EIF3L 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 EIF3L 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 EIF3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EIF3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 EIF3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EIF3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004E008F EIF3L 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000007FBA EIF3L 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD EIF3L 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000355E82 EIF3L 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000209F04 EIF3L 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 EIF3L 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C EIF3L 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001496AE EIF3L 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
EIF3G EIF3L 25348397 N/A physical interaction ComPPI
SNW1 EIF3L 20467437 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
EIF1B EIF3L 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF3H EIF3L 23623729 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
ZNRD2 EIF3L 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NPM1 EIF3L 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPS28 EIF3L 25348397 N/A physical interaction ComPPI
MCM2 EIF3L 25348397 N/A physical interaction ComPPI
EIF3E EIF3L 11590142 14525934 18599441 19748344 23623729 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,mass spectrometry studies of complexes,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
LARP1 EIF3L 25348397 N/A physical interaction ComPPI
RPL10 EIF3L 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CD81 EIF3L 25348397 N/A physical interaction ComPPI
JUN EIF3L 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
SMAD2 EIF3L 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
NTRK1 EIF3L 25348397 N/A physical interaction ComPPI
XRN2 EIF3L 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
RGS2 EIF3L 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CFTR EIF3L 25348397 N/A physical interaction ComPPI
EIF3C EIF3L 18599441 23623729 24234451 25348397 association,physical association mass spectrometry studies of complexes,pull down,physical interaction ComPPI,IntAct
EIF3F EIF3L 23623729 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
XPO1 EIF3L 25348397 N/A physical interaction ComPPI
RPS25 EIF3L 25348397 N/A physical interaction ComPPI
RPS18 EIF3L 25348397 N/A physical interaction ComPPI
RPS13 EIF3L 25348397 N/A physical interaction ComPPI
CUL1 EIF3L 25348397 N/A physical interaction ComPPI
RNF2 EIF3L 25348397 N/A physical interaction ComPPI
YAP1 EIF3L 25348397 N/A physical interaction ComPPI
EIF3I EIF3L 25348397 N/A physical interaction ComPPI
VCAM1 EIF3L 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ITGA4 EIF3L 25348397 N/A physical interaction ComPPI
DDX3X EIF3L 25348397 N/A physical interaction ComPPI
HDAC5 EIF3L 25348397 N/A physical interaction ComPPI
EIF2B5 EIF3L 25348397 N/A physical interaction ComPPI
EIF3J EIF3L 23623729 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
H2AX EIF3L 25348397 N/A physical interaction ComPPI
EIF4A2 EIF3L 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
GNB2 EIF3L 25348397 N/A physical interaction ComPPI
BRCA1 EIF3L 25348397 N/A physical interaction ComPPI
PTP4A1 EIF3L 25348397 N/A physical interaction ComPPI
EIF3D EIF3L 11590142 14525934 18599441 23623729 24234451 25348397 association,physical association experimental interaction detection,mass spectrometry studies of complexes,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
EIF3A EIF3L 17353931 18599441 23623729 24234451 25348397 association,physical association anti bait coimmunoprecipitation,transmission electron microscopy,mass spectrometry studies of complexes,molecular sieving,pull down,physical interaction,ion exchange chromatography,electron tomography ComPPI,IntAct
EIF3B EIF3L 18599441 24234451 25348397 physical association anti tag coimmunoprecipitation,mass spectrometry studies of complexes,physical interaction ComPPI,IntAct
EIF3L POLR1B 11592397 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
EIF3L RRN3 12393749 14525934 15004009 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
EIF3L EIF3K 14525934 16189514 18599441 19748344 21516116 23623729 24234451 25348397 25416956 association,physical association anti tag coimmunoprecipitation,two hybrid,mass spectrometry studies of complexes,pull down,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
EIF3L TADA2A 25348397 N/A physical interaction ComPPI
EIF3L AGO3 19167051 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF3L SIRT7 25348397 N/A physical interaction ComPPI
EIF3L EIF3M 23623729 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
EIF3L NCL 25348397 N/A physical interaction ComPPI
EIF3L FN1 25348397 N/A physical interaction ComPPI
EIF3L IGSF8 25348397 N/A physical interaction ComPPI
EIF3L ICAM1 25348397 N/A physical interaction ComPPI
EIF3L KCMF1 25348397 N/A physical interaction ComPPI
EIF3L RPS16 25348397 N/A physical interaction ComPPI
EIF3L RPS20 25348397 N/A physical interaction ComPPI
EIF3L RPS4X 25348397 N/A physical interaction ComPPI
EIF3L RPS5 25348397 N/A physical interaction ComPPI
EIF3L RPS8 25348397 N/A physical interaction ComPPI
EIF3L RPS9 25348397 N/A physical interaction ComPPI
EIF3L RIOK2 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
EIF3L EIF3CL 25348397 N/A physical interaction ComPPI
EIF3L NUMA1 25348397 N/A physical interaction ComPPI
EIF3L HERC2 24234451 25348397 29426014 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF3L HERC2P3 25348397 N/A physical interaction ComPPI
EIF3L AHSA1 25348397 N/A physical interaction ComPPI
EIF3L GAN 25348397 N/A physical interaction ComPPI
EIF3L C1ORF131 25348397 N/A physical interaction ComPPI
EIF3L ZNF746 25348397 N/A physical interaction ComPPI
EIF3L PRRC2B 25348397 N/A physical interaction ComPPI
EIF3L PSMD12 25348397 N/A physical interaction ComPPI
EIF3L TTC21B 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
EIF3L CYLD 25348397 N/A physical interaction ComPPI
EIF3L G3BP1 25348397 N/A physical interaction ComPPI
EIF3L DNM2 14525934 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
EIF3L HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF3L TMBIM4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF3L GH1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF3L LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
EIF3L CEP170P1 24234451 25348397 26496610 association anti tag coimmunoprecipitation ComPPI,IntAct
EIF3L PPP1R18 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EIF3L PHACTR3 24234451 25348397 28330616 association pull down ComPPI,IntAct
APPL EIF3L 25348397 N/A anti tag coimmunoprecipitation ComPPI
EIF3L ARM 25348397 N/A anti tag coimmunoprecipitation ComPPI
EIF3L DSOR1 25348397 N/A physical interaction ComPPI
L1TD1 EIF3L 24234451 25702638 association anti bait coimmunoprecipitation IntAct
TPT1 EIF3L 24234451 27607350 association anti bait coimmunoprecipitation IntAct

Visualization










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