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GENE：MAP2K4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP2K4
FullNmae mitogen-activated protein kinase kinase 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6844
EnsembleID ENSG00000065559
Uniprot P45985

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP2K4 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP2K4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAP2K4 GO:0000165,GO:0001934,GO:0004672,GO:0004674,GO:0004713,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0007165,GO:0007254,GO:0008545,GO:0008545,GO:0009611,GO:0016310,GO:0030424,GO:0032839,GO:0034390,GO:0036481,GO:0038095,GO:0043204,GO:0043525,GO:0045740,GO:0046330,GO:0051770,GO:0060090,GO:0061049,GO:0071260,GO:0072709,GO:0090398,GO:0106310,GO:2000672

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP2K4 hsa:6416 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MAP2K4 hsa:6416 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
MAP2K4 hsa:6416 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
MAP2K4 hsa:6416 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
MAP2K4 hsa:6416 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
MAP2K4 hsa:6416 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
MAP2K4 hsa:6416 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
MAP2K4 hsa:6416 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
MAP2K4 hsa:6416 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
MAP2K4 hsa:6416 path:hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
MAP2K4 hsa:6416 path:hsa05132 Salmonella infection - Homo sapiens (human)
MAP2K4 hsa:6416 path:hsa05135 Yersinia infection - Homo sapiens (human)
MAP2K4 hsa:6416 path:hsa05142 Chagas disease - Homo sapiens (human)
MAP2K4 hsa:6416 path:hsa05161 Hepatitis B - Homo sapiens (human)
MAP2K4 hsa:6416 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
MAP2K4 hsa:6416 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
MAP2K4 hsa:6416 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
MAP2K4 hsa:6416 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
MAP2K4 hsa:6416 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)
MAP2K4 hsa:6416 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CRK MAP2K4 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26192618 26552706 8551221 interaction type N/A ACSN
CRKL MAP2K4 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26192618 26552706 8551221 interaction type N/A ACSN
FLT4 MAP2K4 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26192618 26552706 8551221 interaction type N/A ACSN
GRB2 MAP2K4 10086337 10567412 10811803 10982827 11274345 11447289 11756498 11777939 12040186 12175651 12640133 12738796 14585353 15567848 15574420 15863030 16102570 16582911 16887996 17496910 17673906 18000759 18855897 19151919 19449109 19568798 21614932 24027568 26192618 26552706 27331412 7510700 8551221 interaction type N/A ACSN
SHC1 MAP2K4 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26192618 26552706 8551221 interaction type N/A ACSN
THBS1 MAP2K4 10657674 10811870 11257133 11823516 11982756 14568985 14996710 19090789 20531300 22943793 23170255 23510023 25001536 26192618 26819959 28258062 8349738 8777713 9242610 9858524 interaction type N/A ACSN
MAP3K1 MAP2K4 10086337 10465784 10567412 10811803 10982827 11242034 11274345 11447289 11668179 11777939 12040186 12048245 12175651 12419216 12456688 12640133 12738796 12782630 14585353 15170913 15567848 15574420 15863030 16102570 16227978 16488589 16582911 16887996 17496910 17496911 17673906 18182252 18855897 19449109 19568798 19615955 21102635 21614932 23180781 23331499 24027568 26192618 26552706 7510700 8551221 9379049 9582321 interaction type,phosphorylation reaction,stimulation,physical association anti tag coimmunoprecipitation,in-gel kinase assay ACSN,InnateDB,SignaLink,SignaLink
MAP3K4 MAP2K4 11175814 11274345 12738796 16799472 18855897 21614932 23331499 23850759 24104473 26192618 9305639 9841871 interaction type,stimulation N/A ACSN,SignaLink
MAP3K7 MAP2K4 10391247 11280761 11460167 11477091 12620219 13130464 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23109003 23681101 24403530 24699077 24958845 26192618 8177321 9851932 interaction type,chemical activation reaction N/A ACSN,SignaLink
TAB2 MAP2K4 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845 26192618 interaction type N/A ACSN
TAB3 MAP2K4 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845 26192618 interaction type N/A ACSN
RAC1 MAP2K4 10086337 10567412 10811803 10982827 11274345 11447289 11756498 11777939 12040186 12175651 12640133 12738796 14585353 15567848 15574420 15863030 16102570 16582911 16887996 17496910 17673906 18000759 18855897 19151919 19449109 19568798 21614932 24027568 26192618 26552706 27331412 7510700 8551221 interaction type N/A ACSN
MAP3K5 MAP2K4 11274345 12556535 12655147 12738796 12878192 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23331499 23850759 24378531 26192618 interaction type,stimulation N/A ACSN,SignaLink
RIPK1 MAP2K4 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26192618 26587781 26653790 28574505 28765050 interaction type N/A ACSN
TNFRSF1A MAP2K4 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26192618 26587781 26653790 28574505 28765050 interaction type N/A ACSN
TRADD MAP2K4 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26192618 26587781 26653790 28574505 28765050 interaction type N/A ACSN
TRAF2 MAP2K4 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531 26192618 interaction type N/A ACSN
TNFRSF1B MAP2K4 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531 26192618 interaction type N/A ACSN
TGFBR1 MAP2K4 11274345 12738796 14557817 15265520 15282297 16200688 16474430 17934056 18855897 20060931 20519943 21614932 22703233 23070005 24132110 24336330 24403530 26192618 interaction type N/A ACSN
TGFBR2 MAP2K4 11274345 12738796 14557817 15265520 15282297 16200688 16474430 17934056 18855897 20060931 20519943 21614932 22703233 23070005 24132110 24336330 24403530 26192618 interaction type N/A ACSN
MAP2K4 MAP3K4 23180781 9305639 9841871 phosphorylation reaction in-gel kinase assay InnateDB
MAP2K4 MAPK9 11062067 11242034 12788955 14699111 18988627 23180781 23331499 9841871 phosphorylation reaction,stimulation,physical association gst pull down,in-gel kinase assay InnateDB,SignaLink,SignaLink
PPM1A MAP2K4 23180781 9707433 dephosphorylation reaction phosphatase assay InnateDB
MAP2K4 MAPK8 10713157 11062067 11242034 12788955 13130464 15998799 18988627 21071413 23180781 23331499 9207092 9661668 9808624 phosphorylation reaction,stimulation,physical association anti tag coimmunoprecipitation,gst pull down,protein kinase assay InnateDB,SignaLink,SignaLink
MAPK10 MAP2K4 10715136 12788955 18408005 23180781 phosphorylation reaction,physical association gst pull down,in-gel kinase assay InnateDB
MAP2K4 MAPK14 12788955 23180781 physical association gst pull down InnateDB
MAPK11 MAP2K4 12788955 23180781 physical association gst pull down InnateDB
MAP2K4 PRKCG 11335711 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP2K4 MAP3K20 11836244 23180781 phosphorylation reaction in-gel kinase assay InnateDB
MAP2K4 MAP2K7 13130464 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP2K4 MAP3K2 10713157 23180781 physical association gst pull down InnateDB
MAP2K4 GEMIN5 17541429 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
MAP2K4 MAP3K5 17541429 18408005 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
AKT1 MAP2K4 15998799 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,protein kinase assay InnateDB
MAP2K4 ARRB2 18408005 23180781 physical association gst pull down InnateDB
MAP2K4 MAPK10 10715136 11242034 18408005 18988627 23180781 23331499 stimulation,physical association gst pull down InnateDB,SignaLink,SignaLink
MAP2K4 MAP2K4 23180781 26467481 7535770 7839144 9162092 9724739 phosphorylation reaction,up-regulates activity in-gel kinase assay InnateDB,Signor
CHUK MAP2K4 18182252 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP3K2 MAP2K4 11343802 18988627 23331499 7997270 stimulation N/A SignaLink,SignaLink
MAP3K8 MAP2K4 23331499 8631303 stimulation N/A SignaLink
MAP3K12 MAP2K4 23331499 8637721 stimulation N/A SignaLink
MAP3K11 MAP2K4 23331499 8702571 stimulation N/A SignaLink
FLNA MAP2K4 23331499 9006895 stimulation N/A SignaLink
STK4 MAP2K4 23331499 9182538 stimulation N/A SignaLink
MAP3K10 MAP2K4 23331499 9182538 stimulation N/A SignaLink
MAPK8IP3 MAP2K4 10523642 12189133 23331499 stimulation N/A SignaLink
TAOK2 MAP2K4 10660600 23331499 stimulation N/A SignaLink
MAP3K20 MAP2K4 11836244 23331499 stimulation N/A SignaLink
SPAG9 MAP2K4 12391307 23331499 stimulation N/A SignaLink
SH3RF1 MAP2K4 12514131 23331499 stimulation N/A SignaLink
TAOK3 MAP2K4 10559204 23331499 inhibition N/A SignaLink
MAP3K6 MAP2K4 23331499 9875215 stimulation N/A SignaLink
MAP3K9 MAP2K4 15610029 23331499 stimulation N/A SignaLink
MAP3K3 MAP2K4 23331499 9162092 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ARRB2 MAP2K4 20005715 interaction type N/A PSP,SignaLink
MAPK8IP3 MAP2K4 20005715 interaction type N/A PSP
NPHS1 MAP2K4 20005715 interaction type N/A PSP,SignaLink
MAPK8IP3 MAP2K4 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR MAP2K4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA3 MAP2K4 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MAP2K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MAP2K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAP2K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MAP2K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MAP2K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 MAP2K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HSF2 MAP2K4 11557063 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ED600 MAP2K4 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS000041CB9C MAP2K4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000003ABC4 MAP2K4 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000C85B2 MAP2K4 21572407 25416803 27353001 mrna cleavage,inhibition western blot,clip TarBase
URS00004F4657 MAP2K4 22942087 25416803 mrna cleavage,inhibition array technology TarBase
URS0000083D87 MAP2K4 22942087 25416803 mrna cleavage,inhibition array technology TarBase
URS00001B341F MAP2K4 24556602 25416803 27594411 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002C28B2 MAP2K4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000016E46F MAP2K4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C04A2 MAP2K4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004F859B MAP2K4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000053B1E8 MAP2K4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001067D1 MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000052EA98 MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000011DF MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000224AEA MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003D4175 MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000016D2D4 MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003A8BB2 MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000037B2E0 MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000319E1 MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000496C56 MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 MAP2K4 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SGK1 MAP2K4 22135298 phosphorylation N/A PhosphoSite
MAP2K4 MAPK8 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAP2K4 MAPK14 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAP2K4 MAPK9 22135298 phosphorylation N/A PhosphoSite
MAP2K4 RXRA 22135298 phosphorylation N/A PhosphoSite
MAP2K4 MAPK10 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAP2K4 MAP2K4 22135298 phosphorylation N/A PhosphoSite
MAP3K5 MAP2K4 22135298 phosphorylation N/A PhosphoSite
MAP3K11 MAP2K4 22135298 phosphorylation N/A PhosphoSite
AKT1 MAP2K4 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAP3K10 MAP2K4 25361965 interaction type N/A PTMCode2
MAP2K4 MAP3K10 25361965 interaction type N/A PTMCode2
MAPK14 MAP2K4 25361965 interaction type N/A PTMCode2
MAP2K4 MAP3K8 25361965 interaction type N/A PTMCode2
MAP3K8 MAP2K4 25361965 interaction type N/A PTMCode2
MAP2K4 ARRB2 25361965 interaction type N/A PTMCode2
ARRB2 MAP2K4 25361965 interaction type N/A PTMCode2
MAP2K4 AKT1 25361965 interaction type N/A PTMCode2
MAPK8 MAP2K4 25361965 interaction type N/A PTMCode2
MAP2K4 FLNC 25361965 interaction type N/A PTMCode2
FLNC MAP2K4 25361965 interaction type N/A PTMCode2
MAP2K4 MAP3K2 25361965 interaction type N/A PTMCode2
MAP3K2 MAP2K4 25361965 interaction type N/A PTMCode2
MAPK10 MAP2K4 25361965 interaction type N/A PTMCode2
MAP2K4 MAP3K4 25361965 interaction type N/A PTMCode2
MAP3K4 MAP2K4 25361965 interaction type N/A PTMCode2
MAP2K4 ARRB1 25361965 interaction type N/A PTMCode2
ARRB1 MAP2K4 25361965 interaction type N/A PTMCode2
MAP2K4 MAP2K7 25361965 interaction type N/A PTMCode2
MAP2K7 MAP2K4 25361965 interaction type N/A PTMCode2
MAP2K4 MAP3K1 25361965 interaction type N/A PTMCode2
MAP3K1 MAP2K4 25361965 interaction type N/A PTMCode2
MAP2K4 EFNA4 25361965 interaction type N/A PTMCode2
EFNA4 MAP2K4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CDC5L MAP2K4 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK9 MAP2K4 11062067 14525934 21900206 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
FBP2 MAP2K4 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
VASP MAP2K4 25348397 N/A physical interaction ComPPI
KTI12 MAP2K4 25348397 N/A physical interaction ComPPI
MAPK1 MAP2K4 25348397 N/A physical interaction ComPPI
BLNK MAP2K4 21822214 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK8 MAP2K4 11062067 14525934 16533805 24234451 25348397 9661668 9808624 N/A experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
MAP4K2 MAP2K4 25348397 N/A physical interaction ComPPI
JUN MAP2K4 25348397 N/A physical interaction ComPPI
MAPK14 MAP2K4 14525934 25348397 7716521 9808624 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FLNC MAP2K4 14525934 25348397 9006895 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
FLNA MAP2K4 14525934 25348397 9006895 N/A experimental interaction detection,in vivo ComPPI,HPRD
NBR1 MAP2K4 25348397 N/A physical interaction ComPPI
UBC MAP2K4 25348397 N/A physical interaction ComPPI
MAP2K4 MAP3K8 14525934 25348397 8631303 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAP2K4 MAP3K10 14525934 25348397 9182538 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAP2K4 MAP3K12 25348397 N/A in vitro ComPPI
MAP2K4 EFNA4 14525934 25348397 8755474 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAP2K4 MAPK12 11062067 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAP2K4 MAP3K4 14525934 25348397 9841871 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP2K4 MAP3K7 12556533 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP2K4 MAPK10 10715136 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAP2K4 TRIB1 14525934 15299019 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
MAP2K4 MAP3K2 14525934 25348397 7997270 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAP2K4 SPAG9 12391307 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAP2K4 MAP3K20 11836244 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAP2K4 MAPK8IP3 12189133 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP2K4 DUSP22 11346645 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAP2K4 AKT1 11707464 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP2K4 MAP3K11 25348397 N/A physical interaction ComPPI
MAP2K4 ARRB2 19782076 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
MAP2K4 MAP3K1 24234451 25348397 9808624 phosphorylation reaction,physical association anti tag coimmunoprecipitation,pull down,physical interaction,protein kinase assay ComPPI,IntAct
MAP2K4 ITCH 25348397 N/A physical interaction ComPPI
MAP2K4 PML 25348397 N/A physical interaction ComPPI
MAP2K4 MAP3K5 25348397 N/A physical interaction ComPPI
MAP2K4 MAP2K6 25348397 N/A physical interaction ComPPI
MAP2K4 MAP3K3 25348397 N/A physical interaction ComPPI
MAP2K4 LRRK2 25348397 N/A physical interaction ComPPI
MAP2K4 APP 25348397 N/A physical interaction ComPPI
MAP2K4 MAP2K7 25348397 N/A physical interaction ComPPI
MAP2K4 ARRB1 19782076 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
MAP2K4 GCH1 25348397 N/A physical interaction ComPPI
MAP2K4 GEMIN5 25348397 N/A physical interaction ComPPI
MAP2K4 RBBP8 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAP2K4 EGFR 25348397 N/A physical interaction ComPPI
MAP2K4 FLNB 25348397 N/A physical interaction ComPPI
MAP2K4 TRIM25 25348397 N/A physical interaction ComPPI
MAP2K4 ALDOB 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAP2K4 CYLC2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAP2K4 STX17 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAP2K4 STK4 23386615 24234451 25348397 association tandem affinity purification ComPPI,IntAct
MAP3K14 MAP2K4 10521444 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CFLAR MAP2K4 14525934 17110930 25348397 N/A anti tag coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD
HSCB MAP2K4 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
MAP2K4 MAP2K4 14504284 14525934 16533805 9162092 N/A experimental interaction detection HPRD
MAP2K4 BAK1 16473966 27898060 N/A N/A OmniPath
MAP2K4 BIN2 23341468 27898060 N/A N/A OmniPath
FLNA MAP2K4 27898060 9006895 stimulant N/A OmniPath
ARRB2 MAP2K4 11090355 18408005 19782076 27898060 N/A N/A OmniPath
MAP3K7 MAP2K4 12429732 12556533 27898060 9278437 stimulant N/A OmniPath
MAP2K4 MAPK10 10715136 11062067 1124203 11242034 12788955 15299005 15911620 18083107 18408005 19651622 25201974 27898060 8974401 stimulant N/A OmniPath
MAP3K8 MAP2K4 15833743 22435554 27898060 8631303 stimulant N/A OmniPath
MAP2K4 MAPK9 11062067 1124203 12788955 14699111 17192257 17634293 18083107 18818208 19369195 19534553 20145118 21900206 22366412 22730327 27898060 9841871 stimulant N/A OmniPath
MAP2K4 MAP3K1 10713157 11274345 12228228 12456688 12738796 14500727 14581471 15299005 15866172 16472679 18182252 18855897 21614932 27898060 9712898 9808624 N/A N/A OmniPath
MAP3K1 MAP2K4 10713157 11274345 12228228 12456688 12738796 14500727 14581471 15299005 15866172 16472679 18182252 18855897 21614932 27898060 9712898 9808624 stimulant N/A OmniPath
MAP3K2 MAP2K4 10713157 11343802 17906693 27898060 7997270 9162092 stimulant N/A OmniPath
AKT1 MAP2K4 11707464 15998799 27898060 inhibition N/A OmniPath
MAP2K4 AKT1 11707464 15998799 27898060 N/A N/A OmniPath
SH3RF1 MAP2K4 12514131 27898060 stimulant N/A OmniPath
PPM1A MAP2K4 27898060 9707433 inhibition N/A OmniPath
MAP2K4 PPM1A 27898060 9707433 N/A N/A OmniPath
MAP2K4 MAP3K5 11274345 12738796 15258908 15299005 15310755 17541429 18408005 18855897 21614932 27898060 8974401 N/A N/A OmniPath
MAP3K5 MAP2K4 11274345 12738796 15258908 15299005 15310755 15911620 17541429 18408005 18855897 21614932 27898060 8974401 stimulant N/A OmniPath
STK4 MAP2K4 27898060 9182538 stimulant N/A OmniPath
PRKCG MAP2K4 11335711 27898060 N/A N/A OmniPath
MAP2K4 MAPK14 12788955 27898060 7535770 7716521 7839144 9162092 9808624 stimulant N/A OmniPath
MAP2K4 RXRA 10377179 10938283 12048211 27898060 inhibition N/A OmniPath
MAPK1 MAP2K4 11707464 16000309 27898060 N/A N/A OmniPath
MAPK8IP1 MAP2K4 27898060 9733513 stimulant N/A OmniPath
MAP2K4 MAP3K4 11274345 12738796 15866172 18855897 21614932 27898060 9305639 9841871 N/A N/A OmniPath
MAP3K4 MAP2K4 11274345 12738796 15866172 18855897 21614932 27898060 9305639 9841871 stimulant N/A OmniPath
PPP2CA MAP2K4 10322434 27898060 N/A N/A OmniPath
MAP2K4 MAPK11 12788955 27898060 stimulant N/A OmniPath
MAP2K4 MAP2K7 13130464 27898060 N/A N/A OmniPath
MAP3K3 MAP2K4 25043814 27898060 9162092 stimulant N/A OmniPath
MAPK8 MAP2K4 10713157 11062067 11242034 11279118 11707464 12391307 12788955 13130464 15998799 16533805 27898060 9162092 9207092 9661668 9808624 N/A N/A OmniPath
MAP2K4 MAPK8 10713157 11062067 11242034 11279118 11707464 12391307 12788955 13130464 15302099 15755722 15911620 15998799 16153436 16533805 17192257 18083107 18669648 19369195 19534553 19690332 23416355 27898060 7839144 9162092 9207092 9661668 9724739 9808624 stimulant N/A OmniPath
SPAG9 MAP2K4 12391307 27898060 stimulant N/A OmniPath
MAP2K4 GEMIN5 17541429 27898060 N/A N/A OmniPath
TAOK2 MAP2K4 10660600 27898060 stimulant N/A OmniPath
MAP3K10 MAP2K4 27898060 8702571 9182538 stimulant N/A OmniPath
MAP2K4 MAPK12 11062067 19413330 27898060 stimulant N/A OmniPath
MAP3K20 MAP2K4 11416147 11836244 27898060 stimulant N/A OmniPath
MAPK8IP3 MAP2K4 10523642 1218913 12189133 27898060 stimulant N/A OmniPath
MAP3K11 MAP2K4 10727406 11053428 15328343 16000309 17276500 27898060 8702571 9003778 9162092 stimulant N/A OmniPath
MAP3K6 MAP2K4 27898060 9875215 stimulant N/A OmniPath
MAP3K12 MAP2K4 10187804 19369195 27898060 stimulant N/A OmniPath
PPP2CB MAP2K4 10322434 27898060 N/A N/A OmniPath
MAP2K4 PHKA1 10487978 10937878 27898060 N/A N/A OmniPath

Visualization










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