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GENE：HIPK3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HIPK3
FullNmae homeodomain interacting protein kinase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4915
EnsembleID ENSG00000110422
Uniprot Q9H422

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HIPK3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HIPK3 GO:0004672,GO:0004674,GO:0004674,GO:0004674,GO:0004713,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0006915,GO:0009299,GO:0016604,GO:0016605,GO:0018105,GO:0018105,GO:0018107,GO:0018107,GO:0043066,GO:0043508,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HIPK3 hsa:10114 path:hsa04218 Cellular senescence - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ARRB2 HIPK3 20005715 interaction type N/A PSP
FADD HIPK3 20005715 interaction type N/A PSP
SNIP1 HIPK3 20005715 interaction type N/A PSP
TGFB1I1 HIPK3 20005715 interaction type N/A PSP
SNIP1 HIPK3 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 HIPK3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 HIPK3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
AR HIPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 HIPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HIPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HIPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 HIPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HIPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HIPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF HIPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 HIPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 HIPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 HIPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR HIPK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000039E1E1 HIPK3 17575136 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00002B3783 HIPK3 17575136 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000009262D HIPK3 17991735 rna interference,inhibition array technology,quantitative reverse transcription pcr miRSponge
URS00002B3783 HIPK3 17575136 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000039E1E1 HIPK3 17575136 23807165 25416803 mrna cleavage,inhibition array technology,miRNA interference luciferase reporter assay TarBase
URS000009262D HIPK3 22815788 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS0000237AF9 HIPK3 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00001EB9FC HIPK3 24149837 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00000F4AC3 HIPK3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075A513 HIPK3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD HIPK3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000018C928 HIPK3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000148B91 HIPK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E HIPK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 HIPK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D HIPK3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000052E1A6 HIPK3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 HIPK3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B HIPK3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00005E1A16 HIPK3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000140295 HIPK3 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000482389 HIPK3 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000075D860 HIPK3 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000480E22 HIPK3 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000043B1D HIPK3 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000B1B47 HIPK3 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000025307A HIPK3 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000328C0D HIPK3 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 HIPK3 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000BA274 HIPK3 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000045147B HIPK3 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000184017 HIPK3 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 HIPK3 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
HIPK3 SUMO1 25361965 interaction type N/A PTMCode2
SUMO1 HIPK3 25361965 interaction type N/A PTMCode2
TP53 HIPK3 25361965 interaction type N/A PTMCode2
HIPK3 TP53 25361965 interaction type N/A PTMCode2
FADD HIPK3 25361965 interaction type N/A PTMCode2
HIPK3 FADD 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I HIPK3 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
DAXX HIPK3 25348397 N/A in vitro ComPPI
SKIL HIPK3 14525934 15231748 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SNIP1 HIPK3 14525934 15231748 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
HEYL HIPK3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ZYX HIPK3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SIAH2 HIPK3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ZNF107 HIPK3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
GRB2 HIPK3 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
AR HIPK3 14525934 25348397 9725910 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
SUMO1 HIPK3 10961991 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
FLNC HIPK3 14525934 15231748 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SIAH1 HIPK3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
HNRNPL HIPK3 25348397 N/A physical interaction ComPPI
TP73 HIPK3 25348397 N/A physical interaction ComPPI
FADD HIPK3 10640736 11034606 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
C1QA HIPK3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
NR2F2 HIPK3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
HNRNPA2B1 HIPK3 25348397 N/A physical interaction ComPPI
SRSF1 HIPK3 25348397 N/A physical interaction ComPPI
ARRB2 HIPK3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
TGFB1I1 HIPK3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
RGS3 HIPK3 14525934 15231748 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
TRA2B HIPK3 25348397 N/A physical interaction ComPPI
HIPK3 FAS 11034606 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
HIPK3 TOX4 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
HIPK3 MBD1 14525934 15231748 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
HIPK3 MTMR4 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
HIPK3 LIMK2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HIPK3 LIMS2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HIPK3 LIMD1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
HIPK3 GORASP1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
HIPK3 TP53 23602568 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
HIPK3 CREB1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HIPK3 SRSF5 25348397 N/A physical interaction ComPPI
HIPK3 HNRNPA1 25348397 N/A physical interaction ComPPI
HIPK3 HNRNPH1 25348397 N/A physical interaction ComPPI
HIPK3 TRIM25 25348397 N/A physical interaction ComPPI
GLUL HIPK3 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HIPK3 FADD 10640736 11034606 19413330 19664995 20068231 20230923 27898060 N/A N/A OmniPath
HIPK3 MAD2L1 12574116 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B6043 HIPK3 27087310 direct interaction,inhibition N/A NPInter

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