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GENE：NLK

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NLK
FullNmae nemo like kinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:29858
EnsembleID ENSG00000087095
Uniprot Q9UBE8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NLK autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NLK GO:0000165,GO:0000287,GO:0004672,GO:0004674,GO:0004674,GO:0004707,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006468,GO:0007179,GO:0007223,GO:0018107,GO:0030178,GO:0031625,GO:0035556,GO:0035556,GO:0042169,GO:0042501,GO:0050821,GO:0071470,GO:0106310,GO:0140297,GO:1904262

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NLK hsa:51701 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
NLK hsa:51701 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
NLK hsa:51701 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
NLK hsa:51701 path:hsa04520 Adherens junction - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TAB1 NLK 10391247 11274345 12620219 14660645 14960582 15082531 18264787 18855897 20194509 23070005 26192618 interaction type N/A ACSN
TAB2 NLK 10391247 11274345 12620219 14660645 14960582 15082531 18264787 18855897 20194509 23070005 26192618 interaction type N/A ACSN
HIPK2 NLK 10391247 11925430 12851404 15082531 17349959 18974774 19828042 21118996 26192618 interaction type N/A ACSN
SOX11 NLK 23180781 24681958 physical association anti tag coimmunoprecipitation InnateDB
NLK SMAD4 21988832 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
NLK RCHY1 21988832 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
MAP3K7 NLK 10391247 23331499 stimulation N/A SignaLink
NLK LEF1 12556497 12901858 19623618 23331499 stimulation N/A SignaLink
WNT5A NLK 20706670 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 NLK 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 NLK 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 NLK 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 NLK 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 NLK 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 NLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 NLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXO1 NLK 23144700 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 NLK 15764709 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000018C928 NLK 19585654 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00001A7F58 NLK 23416699 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000018C928 NLK 18927107 19585654 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay miR2Disease,TarBase
URS00000F31F4 NLK 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 NLK 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00001A7F58 NLK 23416699 25416803 26503628 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00001CC864 NLK 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000029EBD NLK 24608802 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr TarBase
URS0000072E4C NLK 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002E1509 NLK 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000136174 NLK 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F NLK 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 NLK 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB NLK 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 NLK 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000052EA98 NLK 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 NLK 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001CF056 NLK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000042B108 NLK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001B0D1E NLK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD NLK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000277201 NLK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 NLK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000000EF0B NLK 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002F0130 NLK 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000004203C NLK 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000081E1F NLK 25416803 26084278 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
NLK LEF1 22135298 phosphorylation N/A PhosphoSite
NLK SMAD4 22135298 phosphorylation N/A PhosphoSite
NLK TCF7L2 22135298 phosphorylation N/A PhosphoSite
NLK RPTOR 22135298 phosphorylation N/A PhosphoSite
NLK YAP1 22135298 phosphorylation N/A PhosphoSite
NLK FOXO1 22135298 phosphorylation N/A PhosphoSite
STAT3 NLK 25361965 interaction type N/A PTMCode2
NLK STAT3 25361965 interaction type N/A PTMCode2
MYB NLK 25361965 interaction type N/A PTMCode2
NLK MYB 25361965 interaction type N/A PTMCode2
MYBL2 NLK 25361965 interaction type N/A PTMCode2
NLK MYBL2 25361965 interaction type N/A PTMCode2
HIPK2 NLK 25361965 interaction type N/A PTMCode2
NLK HIPK2 25361965 interaction type N/A PTMCode2
CTNNB1 NLK 25361965 interaction type N/A PTMCode2
NLK CTNNB1 25361965 interaction type N/A PTMCode2
CUL1 NLK 25361965 interaction type N/A PTMCode2
NLK CUL1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
QRICH1 NLK 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP5-9 NLK 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP5-6 NLK 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP4-2 NLK 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ATXN1 NLK 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 NLK 21988832 23602568 24234451 25348397 colocalization,association,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,two hybrid array,confocal microscopy,tandem affinity purification ComPPI,IntAct
NLK CREBBP 14525934 14720327 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NLK HIPK2 14525934 15082531 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
NLK STAT3 14525934 15764709 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct
NLK FBXW5 14525934 18765672 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
NLK SKP2 14525934 18765672 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
NLK CUL1 14525934 18765672 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
NLK LEF1 12556497 12901858 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
NLK CTNNB1 25348397 N/A physical interaction ComPPI
NLK TCF7L2 25348397 N/A physical interaction ComPPI
NLK FBXW4 25348397 N/A physical interaction ComPPI
NLK MYB 14525934 15082531 15308626 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
NLK MYBL1 25348397 N/A physical interaction ComPPI
NLK MYBL2 25348397 N/A physical interaction ComPPI
NLK FOXO4 25348397 N/A physical interaction ComPPI
NLK FOXO1 25348397 N/A physical interaction ComPPI
NLK FOXO3 25348397 N/A physical interaction ComPPI
NLK ASGR1 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NLK ELAVL1 25348397 N/A physical interaction ComPPI
NLK USP4 25348397 N/A physical interaction ComPPI
NLK TAB2 25348397 N/A physical interaction ComPPI
NLK MAP3K7 15764709 24234451 25241761 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,proximity ligation assay ComPPI,IntAct
NLK RCHY1 21988832 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,two hybrid array,confocal microscopy ComPPI,IntAct
NLK SDR16C5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NLK KPNB1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK RANBP2 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK WDCP 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK FAM222B 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK FAM222A 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK TNKS1BP1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK SKI 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK RANGAP1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK TLE3 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK CEP97 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK PASK 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK CNOT2 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK CCP110 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK UBAP2L 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK TRPS1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK CNOT11 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK BACH1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK CNOT3 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK SHANK2 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK TP53 25348397 N/A physical interaction ComPPI
NLK MDM2 25348397 N/A physical interaction ComPPI
NLK GRN 24234451 25348397 25416956 25910212 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
NLK ZHX3 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NLK KRTAP10-3 25348397 N/A physical interaction ComPPI
NLK STAT5A 25348397 N/A physical interaction ComPPI
NLK HNRNPL 25348397 N/A physical interaction ComPPI
NLK TFDP1 22773187 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NLK DAPK3 21454679 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NLK KDF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NLK NDOR1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PKM NLK 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
OBI1 NLK 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NLK NLK 12901858 14525934 9448268 N/A experimental interaction detection HPRD
MAP3K7 NLK 10377264 10391247 10823839 11071635 11404460 12482967 12709429 15082531 15640443 20194509 25241761 27898060 7693453 stimulant N/A OmniPath
NLK LEF1 12482967 12556497 12901858 19623618 20194509 22373574 24394665 27898060 inhibition,stimulant N/A OmniPath
NLK MEF2A 10330143 10849446 12586839 17785444 27898060 9858528 N/A N/A OmniPath
NLK RCHY1 21988832 27898060 N/A N/A OmniPath
WNT5A NLK 20706670 27898060 stimulant N/A OmniPath
NLK NOTCH1 20118921 27898060 inhibition N/A OmniPath
NLK SMAD4 19690946 21988832 23602568 27898060 inhibition N/A OmniPath
HIPK2 NLK 15082531 27898060 stimulant N/A OmniPath
NLK MYB 12482967 15082531 15308626 16055500 27898060 inhibition,stimulant N/A OmniPath
NLK STAT3 15764709 17563747 27898060 stimulant N/A OmniPath
NLK TCF7L2 12556497 12901858 27898060 inhibition N/A OmniPath
FZD3 NLK 20828404 27898060 stimulant N/A OmniPath
NLK TCF4 27898060 2861485 inhibition N/A OmniPath
NLK KRT2 21988832 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008B2D26 NLK 27087310 direct interaction,inhibition N/A NPInter
URS00009BA213 NLK 27087310 direct interaction,inhibition N/A NPInter

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