GENE：ACVR2A
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ACVR2A |
| FullNmae | activin A receptor type 2A |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:173 |
| EnsembleID | ENSG00000121989 |
| Uniprot | P27037 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ACVR2A | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ACVR2A | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ACVR2A | GO:0001702,GO:0001934,GO:0004674,GO:0004674,GO:0004675,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0005886,GO:0006468,GO:0007178,GO:0007283,GO:0007368,GO:0007498,GO:0009952,GO:0009986,GO:0015026,GO:0016310,GO:0017002,GO:0019838,GO:0030165,GO:0030501,GO:0030509,GO:0030509,GO:0032924,GO:0032924,GO:0032927,GO:0034673,GO:0034711,GO:0042475,GO:0042713,GO:0043084,GO:0043235,GO:0043621,GO:0045428,GO:0045648,GO:0045669,GO:0045944,GO:0046872,GO:0048179,GO:0048185,GO:0048706,GO:0060011,GO:0071363,GO:0071773,GO:0098821 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ACVR2A | hsa:92 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| ACVR2A | hsa:92 | path:hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| ACVR2A | hsa:92 | path:hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| ACVR2A | hsa:92 | path:hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ERBIN | ACVR2A | 15123239 23180781 | physical association | peptide array | InnateDB |
| ACVR1B | ACVR2A | 23180781 9032295 | physical association | anti tag coimmunoprecipitation | InnateDB |
| BMP2 | ACVR2A | 17295905 17483092 23180781 | physical association | surface plasmon resonance | InnateDB |
| ACVR2B | ACVR2A | 12364468 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | ACVR2A | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | ACVR2A | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | ACVR2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ACVR2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ACVR2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | ACVR2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ACVR2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ACVR2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | ACVR2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000021D7C8 | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS000016D2D4 | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification,clip | TarBase |
| URS00000B59A2 | ACVR2A | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000018E6CD | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005CCD18 | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000486E0B | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000059EB31 | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000250A40 | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000031D186 | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000042619A | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007D64A | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000171CD1 | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040EE1D | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041CB9C | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F0F49 | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000027080C | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000195F5B | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002ECEE4 | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000043D2C1 | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004BC299 | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004AC389 | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005CC20C | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040828B | ACVR2A | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ACVR2A | INHA | 25361965 | interaction type | N/A | PTMCode2 |
| INHA | ACVR2A | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2A | ACVR1 | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR1 | ACVR2A | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2A | ACVRL1 | 25361965 | interaction type | N/A | PTMCode2 |
| ACVRL1 | ACVR2A | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2A | INHBB | 25361965 | interaction type | N/A | PTMCode2 |
| INHBB | ACVR2A | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2A | GDF9 | 25361965 | interaction type | N/A | PTMCode2 |
| GDF9 | ACVR2A | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2A | MAGI2 | 25361965 | interaction type | N/A | PTMCode2 |
| MAGI2 | ACVR2A | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2A | IGSF1 | 25361965 | interaction type | N/A | PTMCode2 |
| IGSF1 | ACVR2A | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2A | GDF5 | 25361965 | interaction type | N/A | PTMCode2 |
| GDF5 | ACVR2A | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2A | BMP2 | 25361965 | interaction type | N/A | PTMCode2 |
| BMP2 | ACVR2A | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2A | BMP7 | 25361965 | interaction type | N/A | PTMCode2 |
| BMP7 | ACVR2A | 25361965 | interaction type | N/A | PTMCode2 |
| TGFBR3 | ACVR2A | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2A | TGFBR3 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| DAXX | ACVR2A | 11483955 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| BMP7 | ACVR2A | 12667445 14525934 25348397 9748228 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| ERBIN | ACVR2A | 25348397 | N/A | physical interaction | ComPPI |
| TGFBR2 | ACVR2A | 25348397 | N/A | physical interaction | ComPPI |
| SYNJ2BP | ACVR2A | 11882656 14525934 15451561 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD |
| ACVR1B | ACVR2A | 25348397 | N/A | coimmunoprecipitation,physical interaction,physical interaction | ComPPI |
| TGFBR3 | ACVR2A | 10746731 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| ACVRL1 | ACVR2A | 10187774 14525934 25348397 | N/A | coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| TLR2 | ACVR2A | 25348397 | N/A | physical interaction | ComPPI |
| IGSF1 | ACVR2A | 11266516 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| MAGI2 | ACVR2A | 10681527 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD |
| BMP2 | ACVR2A | 25348397 | N/A | physical interaction,surface plasmon resonance array | ComPPI |
| ACVR1 | ACVR2A | 25348397 | N/A | coimmunoprecipitation,physical interaction,physical interaction | ComPPI |
| ENG | ACVR2A | 14525934 25348397 9872992 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| GDF5 | ACVR2A | 25348397 | N/A | physical interaction,in vivo | ComPPI |
| GDF9 | ACVR2A | 12135884 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| INHBA | ACVR2A | 11266516 14525934 25348397 | N/A | coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| INHBB | ACVR2A | 11266516 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| BMP6 | ACVR2A | 10504300 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| INHBC | ACVR2A | 12651901 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| TNFRSF10A | ACVR2A | 25348397 | N/A | physical interaction | ComPPI |
| PEG10 | ACVR2A | 25348397 | N/A | physical interaction | ComPPI |
| RNF11 | ACVR2A | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2A | DYNLT4 | 14525934 16982625 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
| ACVR2A | GDF2 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2A | BMP10 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2A | GINM1 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2A | PTGER3 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2A | HEPACAM2 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2A | LDLRAD4 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2A | LRRIQ1 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2A | HAVCR2 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2A | MRAP2 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2A | PCDHAC1 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2A | DAAM2 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2A | RUSF1 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2A | PRSS50 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2A | RGMB | 25348397 | N/A | physical interaction | ComPPI |
| INHA | ACVR2A | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2A | ACVR1 | 27898060 8612709 9748228 | stimulant | N/A | OmniPath |
| BMP2 | ACVR2A | 10880444 17295905 17483092 21702718 25938661 27898060 | N/A | N/A | OmniPath |
| ERBIN | ACVR2A | 15123239 27898060 | N/A | N/A | OmniPath |
| TDGF1 | ACVR2A | 12682303 27898060 | inhibition,stimulant | N/A | OmniPath |
| ACVR2A | ACVR1B | 11927552 12682303 27898060 8612709 9032295 9892009 | stimulant | N/A | OmniPath |
| BMP15 | ACVR2A | 2419820 27898060 | N/A | N/A | OmniPath |
| GDF2 | ACVR2A | 19996292 27898060 | N/A | N/A | OmniPath |
| BMP7 | ACVR2A | 12667445 27898060 9748228 | stimulant | N/A | OmniPath |
| INHBA | ACVR2A | 10746731 11266516 12466190 1646080 27898060 8242742 9202237 9605406 | stimulant | N/A | OmniPath |
| INHBE | ACVR2A | 22710174 27898060 | stimulant | N/A | OmniPath |
| INHBC | ACVR2A | 12651901 22710174 27898060 | stimulant | N/A | OmniPath |