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GENE：FOSL2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FOSL2
FullNmae FOS like 2, AP-1 transcription factor subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3798
EnsembleID ENSG00000075426
Uniprot P15408

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FOSL2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
FOSL2 GO:0000785,GO:0000902,GO:0000977,GO:0000978,GO:0000981,GO:0000981,GO:0001228,GO:0001649,GO:0001666,GO:0001865,GO:0002062,GO:0002437,GO:0003334,GO:0003417,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0006357,GO:0006357,GO:0008219,GO:0009410,GO:0010467,GO:0030183,GO:0030223,GO:0030225,GO:0030282,GO:0030316,GO:0032496,GO:0032964,GO:0035264,GO:0035962,GO:0035988,GO:0036446,GO:0040014,GO:0042100,GO:0042593,GO:0045087,GO:0045444,GO:0045944,GO:0048146,GO:0048745,GO:0048771,GO:0048873,GO:0050852,GO:0051384,GO:0060427,GO:0060613,GO:0061144,GO:0070254,GO:0090575,GO:0098760,GO:0140459,GO:1901142,GO:1904606,GO:1904760,GO:1904975,GO:1990823

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FOSL2 hsa:2355 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NOS2 FOSL2 12788789 23180781 physical association electrophoretic mobility supershift assay InnateDB
FOSL2 IL11 23180781 9488674 physical association electrophoretic mobility supershift assay InnateDB
FOSL2 EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
ELF1 FOSL2 23180781 7648395 physical association anti tag coimmunoprecipitation InnateDB
STAT5A FOSL2 23180781 24587342 physical association anti tag coimmunoprecipitation InnateDB
STAT5B FOSL2 23180781 24587342 physical association anti tag coimmunoprecipitation InnateDB
JUND FOSL2 12354764 23180781 physical association electrophoretic mobility supershift assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR FOSL2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 FOSL2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 FOSL2 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 FOSL2 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 FOSL2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 FOSL2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 FOSL2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 FOSL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FOSL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FOSL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FOSL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FOSL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FOSL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FOSL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF FOSL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 FOSL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 FOSL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000148B91 FOSL2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000157026 FOSL2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000214763 FOSL2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000047A8F FOSL2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075B538 FOSL2 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 FOSL2 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 FOSL2 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 FOSL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 FOSL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 FOSL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE FOSL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A FOSL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D FOSL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A FOSL2 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 FOSL2 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 FOSL2 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 FOSL2 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C FOSL2 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000000E601 FOSL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000034E58D FOSL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000023F8DA FOSL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032BD73 FOSL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C1E1 FOSL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032AE90 FOSL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5ECC FOSL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E FOSL2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 FOSL2 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D FOSL2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000007FBA FOSL2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 FOSL2 25416803 28393251 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000AD002 FOSL2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 FOSL2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000032835F FOSL2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 FOSL2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 FOSL2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000007F792 FOSL2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
JUND FOSL2 25361965 interaction type N/A PTMCode2
FOSL2 JUND 25361965 interaction type N/A PTMCode2
FOSL2 JUNB 25361965 interaction type N/A PTMCode2
JUNB FOSL2 25361965 interaction type N/A PTMCode2
FOSL2 JUN 25361965 interaction type N/A PTMCode2
JUN FOSL2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GMCL1 FOSL2 25348397 N/A physical interaction ComPPI
FHL3 FOSL2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DPY30 FOSL2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
JUNB FOSL2 14499865 14525934 19321746 20102225 24234451 25348397 26186194 26496610 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,peptide array,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach ComPPI,HPRD,IntAct,OmniPath
KBTBD7 FOSL2 25348397 N/A physical interaction ComPPI
DDIT4L FOSL2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
JUN FOSL2 11708771 14525934 20102225 24234451 25348397 25609649 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,peptide array,physical interaction,two hybrid array,in vivo,tandem affinity purification,two hybrid prey pooling approach ComPPI,HPRD,IntAct
FOSL2 JUND 10713367 12052862 14525934 20102225 24234451 25348397 26496610 association anti tag coimmunoprecipitation,experimental interaction detection,peptide array,physical interaction,in vitro ComPPI,HPRD,IntAct
FOSL2 EP300 25348397 N/A physical interaction ComPPI
FOSL2 ATF1 25348397 N/A physical interaction ComPPI
FOSL2 SRA1 25348397 N/A physical interaction ComPPI
FOSL2 DDIT3 20102225 24234451 25348397 27107012 physical association peptide array,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
FOSL2 TRAF1 24234451 25348397 25416956 27107012 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
FOSL2 CREB5 25348397 N/A physical interaction ComPPI
FOSL2 LUZP4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FOSL2 GOPC 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FOSL2 GMCL2 25348397 N/A physical interaction ComPPI
FOSL2 BRCA1 24234451 25348397 29656893 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
FOSL2 ATF7 20102225 24234451 25348397 N/A peptide array,physical interaction ComPPI,IntAct
FOSL2 SORL1 25348397 N/A physical interaction ComPPI
FOSL2 ZZEF1 25348397 N/A physical interaction ComPPI
FOSL2 CARM1 25348397 N/A physical interaction ComPPI
FOSL2 CALCOCO1 25348397 N/A physical interaction ComPPI
FOSL2 VARS1 25348397 N/A physical interaction ComPPI
FOSL2 HECTD3 25348397 N/A physical interaction ComPPI
FOSL2 ANKHD1 25348397 N/A physical interaction ComPPI
FOSL2 ANKRD17 25348397 N/A physical interaction ComPPI
FOSL2 IRF2BP2 25348397 N/A physical interaction ComPPI
FOSL2 CYTH2 25348397 N/A physical interaction ComPPI
FOSL2 CYTH3 25348397 N/A physical interaction ComPPI
FOSL2 COP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FOSL2 KBTBD6 25348397 N/A physical interaction ComPPI
FOSL2 TSR3 25348397 N/A physical interaction ComPPI
FOSL2 NBEA 25348397 N/A physical interaction ComPPI
FOSL2 FBXO11 25348397 N/A physical interaction ComPPI
FOSL2 BACH2 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FOSL2 YEATS4 25348397 N/A physical interaction ComPPI
FOSL2 STK40 25348397 N/A physical interaction ComPPI
FOSL2 RUFY1 25348397 N/A physical interaction ComPPI
FOSL2 IRF2BP1 25348397 N/A physical interaction ComPPI
FOSL2 DET1 25348397 N/A physical interaction ComPPI
FOSL2 PRMT6 25348397 N/A physical interaction ComPPI
FOSL2 TRIB1 25348397 N/A physical interaction ComPPI
FOSL2 IRF2BPL 25348397 N/A physical interaction ComPPI
FOSL2 EGR1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FOSL2 STMN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FOSL2 RPL21 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FOSL2 RPL30 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FOSL2 SPAST 25348397 N/A physical interaction ComPPI
FOSL2 RECQL5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FOSL2 MED16 25348397 N/A physical interaction ComPPI
FOSL2 METTL17 25348397 N/A physical interaction ComPPI
FOSL2 LSM11 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FOSL2 DNMT3L 25348397 N/A physical interaction ComPPI
FOSL2 USF2 25348397 N/A physical interaction ComPPI
FOSL2 BAHCC1 25348397 N/A physical interaction ComPPI
FOSL2 HNRNPL 25348397 N/A physical interaction ComPPI
FOSL2 MECOM 22308434 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FOSL2 MYC 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
FOSL2 MAFB 20102225 24234451 25348397 N/A peptide array ComPPI,IntAct
FOSL2 ATF3 20102225 24234451 25348397 N/A peptide array ComPPI,IntAct
FOSL2 LRIF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FOSL2 ANKRD36BP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FOSL2 NME7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FOSL2 LHX8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FOSL2 POLR2G 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FOSL2 CYTH1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DNAJA3 FOSL2 25348397 N/A physical interaction,two hybrid prey pooling approach ComPPI
ATF2 FOSL2 20102225 24234451 25348397 physical association peptide array,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EEF1D FOSL2 25348397 N/A physical interaction ComPPI
RPL14 FOSL2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
JUND FOSL2 10713367 12052862 12354764 20102225 26186194 26496610 27898060 N/A N/A OmniPath

Visualization










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