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GENE：ATP2A2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ATP2A2
FullNmae ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:812
EnsembleID ENSG00000174437
Uniprot P16615

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ATP2A2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ATP2A2 GO:0000045,GO:0002026,GO:0005388,GO:0005388,GO:0005509,GO:0005515,GO:0005524,GO:0005783,GO:0005789,GO:0005789,GO:0005886,GO:0006874,GO:0006874,GO:0006984,GO:0007155,GO:0008544,GO:0010460,GO:0010666,GO:0010882,GO:0014883,GO:0014898,GO:0016020,GO:0016240,GO:0016529,GO:0016887,GO:0019899,GO:0031095,GO:0032469,GO:0032470,GO:0033017,GO:0033292,GO:0034220,GO:0034599,GO:0034976,GO:0044325,GO:0044548,GO:0045822,GO:0070050,GO:0070296,GO:0070588,GO:0070588,GO:0086036,GO:0086036,GO:0086036,GO:0086039,GO:0086039,GO:0086039,GO:0086039,GO:0097470,GO:0098909,GO:0140056,GO:1900121,GO:1903233,GO:1903515,GO:1903779,GO:1990036,GO:1990036,GO:1990456

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ATP2A2 hsa:488 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
ATP2A2 hsa:488 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
ATP2A2 hsa:488 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
ATP2A2 hsa:488 path:hsa04148 Efferocytosis - Homo sapiens (human)
ATP2A2 hsa:488 path:hsa04260 Cardiac muscle contraction - Homo sapiens (human)
ATP2A2 hsa:488 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
ATP2A2 hsa:488 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
ATP2A2 hsa:488 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
ATP2A2 hsa:488 path:hsa04972 Pancreatic secretion - Homo sapiens (human)
ATP2A2 hsa:488 path:hsa05010 Alzheimer disease - Homo sapiens (human)
ATP2A2 hsa:488 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
ATP2A2 hsa:488 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
ATP2A2 hsa:488 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
ATP2A2 hsa:488 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)
ATP2A2 hsa:488 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)
ATP2A2 hsa:488 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ATF6 ATP2A2 17991856 18360008 23850759 26192618 26587781 interaction type N/A ACSN
EZH2 ATP2A2 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
SUZ12 ATP2A2 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
RNF2 ATP2A2 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
ADRB2 ATP2A2 23180781 23798571 physical association affinity chromatography technology InnateDB

Source Target Pmid Interactiontype Methods Database
HGS ATP2A2 20005715 interaction type N/A PSP,SignaLink
IRS1 ATP2A2 20005715 interaction type N/A PSP
IRS2 ATP2A2 20005715 interaction type N/A PSP
TRADD ATP2A2 20005715 interaction type N/A PSP
IRS1 ATP2A2 20005715 20005715 N/A N/A SignaLink
IRS2 ATP2A2 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR ATP2A2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 ATP2A2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 ATP2A2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ATP2A2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SP1 ATP2A2 14613864 17597815 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
FOXP3 ATP2A2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ATP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ATP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ATP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ATP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ATP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ATP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ATP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ATP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ATP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ATP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 ATP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ATP2A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF6 ATP2A2 11595740 trascriptional regulation,stimulation inferred by curator TFlink
HAX1 ATP2A2 18971376 trascriptional regulation,stimulation inferred by curator TFlink
PPARG ATP2A2 22240811 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 ATP2A2 14613864 17597815 trascriptional regulation,stimulation inferred by curator TFlink
SP3 ATP2A2 14613864 trascriptional regulation,stimulation inferred by curator TFlink
JUN ATP2A2 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A ATP2A2 N/A trascriptional regulation,stimulation inferred by curator TFlink
USF1 ATP2A2 N/A trascriptional regulation,stimulation inferred by curator TFlink
USF2 ATP2A2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000065D58 ATP2A2 18668040 23313552 25416803 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS00001E0AEA ATP2A2 17612493 22473208 25416803 mrna cleavage,inhibition array technology,clip TarBase
URS000003ABC4 ATP2A2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000324096 ATP2A2 18668040 23622248 25416803 mrna cleavage,inhibition experimental interaction detection,clash TarBase
URS00002971AB ATP2A2 19536157 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00002B7450 ATP2A2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE ATP2A2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000041CB9C ATP2A2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000170CF4 ATP2A2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F4AC3 ATP2A2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A405B ATP2A2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000001EB3 ATP2A2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000031E12 ATP2A2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C85B2 ATP2A2 24670661 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000913AC ATP2A2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 ATP2A2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F ATP2A2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000049FAE8 ATP2A2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000B7E30 ATP2A2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000004203C ATP2A2 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000036AFF1 ATP2A2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000D5FFC ATP2A2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000046CDA6 ATP2A2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 ATP2A2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 ATP2A2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000031F6C2 ATP2A2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 ATP2A2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002CF3F0 ATP2A2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000D2680 ATP2A2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE ATP2A2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 ATP2A2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F ATP2A2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 ATP2A2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 ATP2A2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 ATP2A2 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAD2L2 ATP2A2 24234451 25348397 29656893 association anti tag coimmunoprecipitation ComPPI,IntAct
S100A1 ATP2A2 12804600 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TRAF6 ATP2A2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
KEAP1 ATP2A2 25348397 N/A physical interaction ComPPI
SLN ATP2A2 25348397 N/A physical interaction ComPPI
ERBB2 ATP2A2 24189400 24234451 25348397 association tandem affinity purification ComPPI,IntAct
EZH2 ATP2A2 25348397 N/A physical interaction ComPPI
JUN ATP2A2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
OPRD1 ATP2A2 20528919 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
PKN2 ATP2A2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SPP1 ATP2A2 25348397 N/A physical interaction ComPPI
VAPA ATP2A2 25348397 N/A physical interaction ComPPI
CUL3 ATP2A2 25348397 N/A physical interaction ComPPI
RAB7A ATP2A2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRS2 ATP2A2 14525934 25348397 9295312 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
HGS ATP2A2 25348397 N/A physical interaction ComPPI
PLN ATP2A2 10809745 11526231 11854448 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NTRK1 ATP2A2 25348397 N/A physical interaction ComPPI
CANX ATP2A2 20528919 22045338 24234451 25348397 colocalization,association anti bait coimmunoprecipitation,cosedimentation through density gradient ComPPI,IntAct
ILK ATP2A2 23455922 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
P4HB ATP2A2 22045338 24234451 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
MYC ATP2A2 17314511 17353931 24234451 25348397 association,physical association anti bait coimmunoprecipitation,tandem affinity purification ComPPI,IntAct
TNFRSF1A ATP2A2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CFTR ATP2A2 17110338 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TNF ATP2A2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PDHA1 ATP2A2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ECT2 ATP2A2 25348397 N/A physical interaction ComPPI
RPS6 ATP2A2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MDM2 ATP2A2 25348397 N/A physical interaction ComPPI
ATP1B1 ATP2A2 25348397 N/A physical interaction ComPPI
ADRB2 ATP2A2 25348397 N/A physical interaction ComPPI
EGFR ATP2A2 15657067 24189400 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
IRS1 ATP2A2 14525934 25348397 9295312 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RNF2 ATP2A2 25348397 N/A physical interaction ComPPI
TFDP1 ATP2A2 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
NCSTN ATP2A2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NOS2 ATP2A2 25348397 N/A physical interaction ComPPI
MDC1 ATP2A2 25348397 N/A physical interaction ComPPI
TNFRSF1B ATP2A2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
BCL2 ATP2A2 14525934 25348397 27898060 9788433 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
ATP2A2 PTP4A3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP2A2 HDAC5 25348397 N/A physical interaction ComPPI
ATP2A2 AMFR 25348397 N/A physical interaction ComPPI
ATP2A2 ELAVL1 25348397 N/A physical interaction ComPPI
ATP2A2 SIRT7 25348397 N/A physical interaction ComPPI
ATP2A2 FBXO25 25348397 N/A physical interaction ComPPI
ATP2A2 TRIM13 25348397 N/A physical interaction ComPPI
ATP2A2 ITPR3 22045338 24234451 25348397 colocalization cosedimentation through density gradient,physical interaction ComPPI,IntAct
ATP2A2 SLC3A2 25348397 N/A physical interaction ComPPI
ATP2A2 CLN3 25348397 N/A physical interaction ComPPI
ATP2A2 CLN5 25348397 N/A physical interaction ComPPI
ATP2A2 ASB1 25348397 N/A physical interaction ComPPI
ATP2A2 ASB14 25348397 N/A physical interaction ComPPI
ATP2A2 ASB17 25348397 N/A physical interaction ComPPI
ATP2A2 LGR4 25348397 N/A physical interaction ComPPI
ATP2A2 HACD3 25348397 N/A physical interaction ComPPI
ATP2A2 SPRTN 25348397 N/A physical interaction ComPPI
ATP2A2 ERLIN2 21343306 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ATP2A2 CUL7 25348397 N/A physical interaction ComPPI
ATP2A2 CCDC8 25348397 N/A physical interaction ComPPI
ATP2A2 SUZ12 25348397 N/A physical interaction ComPPI
ATP2A2 RIC3 25348397 N/A physical interaction ComPPI
ATP2A2 UNK 25348397 N/A physical interaction ComPPI
ATP2A2 LMAN1 25348397 N/A physical interaction ComPPI
ATP2A2 MTCH2 25348397 N/A physical interaction ComPPI
ATP2A2 UQCRQ 25348397 N/A physical interaction ComPPI
ATP2A2 NDUFS4 25348397 N/A physical interaction ComPPI
ATP2A2 NOTCH2 25348397 N/A physical interaction ComPPI
ATP2A2 TCTN2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ATP2A2 TCTN3 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ATP2A2 CDK1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP2A2 XRCC3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP2A2 SLC33A1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP2A2 KIF23 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP2A2 GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP2A2 TMEM63B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP2A2 TUBA1C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP2A2 MBOAT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP2A2 SKI 25348397 N/A physical interaction ComPPI
ATP2A2 RNF126 25348397 N/A physical interaction ComPPI
ATP2A2 ESRRB 25348397 N/A physical interaction ComPPI
ATP2A2 NEPRO 25348397 N/A physical interaction ComPPI
ATP2A2 DERL1 25348397 N/A physical interaction ComPPI
ATP2A2 ZNF746 25348397 N/A physical interaction ComPPI
ATP2A2 CTDNEP1 25348397 N/A physical interaction ComPPI
ATP2A2 PPEF2 25348397 N/A physical interaction ComPPI
ATP2A2 PTPMT1 25348397 N/A physical interaction ComPPI
ATP2A2 PTPRK 25348397 N/A physical interaction ComPPI
ATP2A2 PTPRT 25348397 N/A physical interaction ComPPI
ATP2A2 TPTE 25348397 N/A physical interaction ComPPI
ATP2A2 TRIM25 25348397 N/A physical interaction ComPPI
ATP2A2 TRADD 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ATP2A2 TMX1 22045338 24234451 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
ATP2A2 E2F3 22157815 24234451 25348397 association pull down ComPPI,IntAct
ATP2A2 L3MBTL1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
ATP2A2 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
ATP2A2 HACD1 24234451 25348397 28330616 association pull down ComPPI,IntAct
ATP2A2 PPEF1 24234451 25348397 28330616 association pull down ComPPI,IntAct
ATP2A2 AIFM1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATP2A2 BET1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATP2A2 TGOLN2 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
AURKAIP1 ATP2A2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ATF2 ATP2A2 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP2A2 ATP2A2 12670936 14525934 N/A experimental interaction detection HPRD
MKI67 ATP2A2 24234451 26949251 association anti tag coimmunoprecipitation IntAct
CLN6 ATP2A2 24234451 30177828 association anti tag coimmunoprecipitation IntAct
F2RL1 ATP2A2 24234451 28298427 physical association anti bait coimmunoprecipitation,ubiquitin reconstruction IntAct
CCR4 ATP2A2 24234451 28298427 physical association ubiquitin reconstruction IntAct
CHRM5 ATP2A2 24234451 28298427 physical association ubiquitin reconstruction IntAct
ATP2A2 NSA2 24234451 30021884 physical association cross-linking study IntAct
ATP2A2 MPTX1 24234451 30021884 physical association cross-linking study IntAct
ATP2A2 SLC4A4 24234451 30021884 physical association cross-linking study IntAct
ATP2A2 PALMD 24234451 30021884 physical association cross-linking study IntAct
ATR ATP2A2 14722118 27898060 7929371 N/A N/A OmniPath
CAMK2A ATP2A2 27898060 7929371 stimulant N/A OmniPath

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