Gene Information gene info

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GENE：FANCL

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FANCL
FullNmae FA complementation group L
LocusType gene with protein product
Status Approved
HGNC_id HGNC:20748
EnsembleID ENSG00000115392
Uniprot Q9NW38

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FANCL autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
FANCL GO:0000785,GO:0004842,GO:0004842,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0006281,GO:0006281,GO:0006513,GO:0006513,GO:0006974,GO:0007276,GO:0016604,GO:0031625,GO:0036297,GO:0042127,GO:0043231,GO:0043240,GO:0043240,GO:0046872,GO:0061630,GO:0061630

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FANCL hsa:55120 path:hsa03460 Fanconi anemia pathway - Homo sapiens (human)
FANCL hsa:55120 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BLM FANCL 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FAAP24 FANCL 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCA FANCL 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCC FANCL 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCE FANCL 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCG FANCL 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCL FAAP100 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCL FAAP20 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCL FANCB 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCL FANCF 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCM FANCL 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
HES1 FANCL 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCL TOP3A 12535671 12972610 16697054 18550849 18931676 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCL FANCD2 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCL FANCI 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
RPA1 FANCL 26192618 association N/A ACSN
RPA2 FANCL 26192618 association N/A ACSN
RPA3 FANCL 26192618 association N/A ACSN
FANCL MRE11 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCL RAD50 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCL ATR 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 26192618 8020957 interaction type N/A ACSN
FANCL UBE2T 16916645 18931676 19264559 19622404 19686080 22266823 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 FANCL 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 FANCL 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 FANCL 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 FANCL 20953172 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 FANCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FANCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FANCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 FANCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FANCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF FANCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001DE669 FANCL 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F FANCL 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 FANCL 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 FANCL 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GGN FANCL 25361965 interaction type N/A PTMCode2
FANCL GGN 25361965 interaction type N/A PTMCode2
FANCM FANCL 25361965 interaction type N/A PTMCode2
FANCL FANCM 25361965 interaction type N/A PTMCode2
FANCA FANCL 25361965 interaction type N/A PTMCode2
FANCL FANCA 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CHCHD3 FANCL 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ZNF581 FANCL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LZTS2 FANCL 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PCNA FANCL 20937699 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CTBP1 FANCL 25348397 N/A physical interaction ComPPI
GRN FANCL 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BAG6 FANCL 25348397 N/A physical interaction ComPPI
FANCD2 FANCL 25348397 N/A physical interaction ComPPI
FANCC FANCL 25348397 N/A physical interaction ComPPI
TFCP2 FANCL 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CTDSP1 FANCL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IKZF3 FANCL 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SSX2IP FANCL 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BMPR1B FANCL 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
FANCF FANCL 25348397 N/A physical interaction ComPPI
SNF8 FANCL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ID2 FANCL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ACVR1 FANCL 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BRCA1 FANCL 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
DOCK8 FANCL 25348397 N/A physical interaction ComPPI
RNF11 FANCL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KIFC3 FANCL 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GGN FANCL 12574169 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD,OmniPath
FANCL HES1 14525934 18550849 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
FANCL FANCA 17289582 17396147 24234451 25348397 colocalization,association anti bait coimmunoprecipitation,molecular sieving,physical interaction ComPPI,IntAct
FANCL FANCM 17289582 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FANCL FANCG 25348397 N/A physical interaction ComPPI
FANCL UBE2W 19111657 19549727 21229326 24234451 25348397 27898060 physical association two hybrid,physical interaction ComPPI,IntAct,OmniPath
FANCL CENPS 25348397 N/A physical interaction ComPPI
FANCL CENPX 25348397 N/A physical interaction ComPPI
FANCL FAAP100 17396147 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,protein three hybrid ComPPI,IntAct
FANCL FANCB 17396147 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FANCL FAAP24 17289582 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FANCL UBE2T 25348397 N/A molecular sieving,physical interaction,physical interaction,comigration in non denaturing gel electrophoresis ComPPI
FANCL FAAP20 25348397 N/A physical interaction ComPPI
FANCL FANCI 25348397 N/A physical interaction ComPPI
FANCL EIF4ENIF1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FANCL RIMBP3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FANCL RBM45 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FANCL IHO1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FANCL IL6R 25348397 N/A physical interaction ComPPI
FANCL CLEC2D 25348397 N/A physical interaction ComPPI
FANCL VSIG1 25348397 N/A physical interaction ComPPI
FANCL PPP1R7 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
FANCL ATRIP 25348397 N/A physical interaction ComPPI
FANCL HDHD3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FANCL HOXD4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FANCL MORN3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FANCL SCNM1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FANCL CERCAM 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FANCL UFSP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FANCL KRTAP13-2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FANCL KRTAP19-6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FANCL ANTKMT 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DDAH2 FANCL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRTAP11-1 FANCL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FANCL TGFBR1 14525934 15761153 N/A experimental interaction detection HPRD
CHEK1 FANCL 19861535 27898060 stimulant N/A OmniPath
UBE2T FANCL 16916645 17768402 19111657 21775430 22287633 24389026 24623813 25464845 26046368 27898060 stimulant N/A OmniPath
ATR FANCL 15314022 27898060 stimulant N/A OmniPath
FANCD2 FANCL 17352736 17488615 19111657 19622405 21775430 22287633 24623813 27898060 stimulant N/A OmniPath
FANCL FANCD2 17352736 17488615 19111657 19622405 21775430 22287633 24623813 27898060 stimulant N/A OmniPath
FANCI FANCL 17488615 19622405 21775430 24623813 27898060 stimulant N/A OmniPath
FANCL FANCI 17488615 19622405 21775430 24623813 27898060 stimulant N/A OmniPath

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